ChemicalBook > CAS DataBase List > γ-Secretase Inhibitor XXI

γ-Secretase Inhibitor XXI

Product Name
γ-Secretase Inhibitor XXI
CAS No.
209986-17-4
Chemical Name
γ-Secretase Inhibitor XXI
Synonyms
DuPont E;Compound E, gamma;-secretase inhibitor;γ-Secretase Inhibitor BZ;γ-Secretase Inhibitor BZ;γ-Secretase Inhibitor XXI;g-Secretase Inhibitor XXI;γ-Secretase Inhibitor XXI;CoMpound E (secretase inhibitor);Compound E (γ-Secretase Inhibitor XXI)
CBNumber
CB42602844
Molecular Formula
C27H24F2N4O3
Formula Weight
490.5
MOL File
209986-17-4.mol
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γ-Secretase Inhibitor XXI Property

Boiling point:
778.6±60.0 °C(Predicted)
Density 
1.31
storage temp. 
= -70C
solubility 
Soluble in DMSO
form 
Liquid
pka
12.54±0.40(Predicted)
color 
White to off-white
Sensitive 
Light Sensitive
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
565790
Product name
γ-Secretase Inhibitor XXI, Compound E - CAS 209986-17-4 - Calbiochem
Purity
Thisg-secretaseinhibitor,CAS209986-17-4,isacell-permeable,potent,select
Packaging
500μg
Price
$345
Updated
2024/03/01
Sigma-Aldrich
Product number
565790
Product name
γ-Secretase Inhibitor XXI, Compound E - CAS 209986-17-4 - Calbiochem
Packaging
1mg
Price
$445
Updated
2024/03/01
Sigma-Aldrich
Product number
5.30509
Product name
StemSelect Compound E - CAS 209986-17-4 - Calbiochem
Packaging
250μg
Price
$209
Updated
2024/03/01
Alfa Aesar
Product number
J65131
Product name
Compound E
Packaging
0.5mg
Price
$307
Updated
2023/06/20
Cayman Chemical
Product number
15579
Product name
Compound E
Purity
≥98%
Packaging
500μg
Price
$189
Updated
2024/03/01
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γ-Secretase Inhibitor XXI Chemical Properties,Usage,Production

Uses

A cell-permeable, potent, selective, peptidomimetic, non-transition-state analog inhibitor of -secretase and Notch processing

Definition

ChEBI: Compound E is an L-alanine derivative that is the amide obtained by formal condensation of the carboxy group of N-[(3,5-difluorophenyl)acetyl]-L-alanine with the amino group of (3S)-3-amino-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one. An inhibitor of memapsin 2 (gamma-secretase). It has a role as an EC 3.4.23.46 (memapsin 2) inhibitor. It is a 1,4-benzodiazepinone, a L-alanine derivative and a difluorobenzene.

storage

+4°C

γ-Secretase Inhibitor XXI Preparation Products And Raw materials

Raw materials

Preparation Products

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209986-17-4, γ-Secretase Inhibitor XXIRelated Search:

BETA-SECRETASE INHIBITOR IV DAPM GAMMA-SECRETASE INHIBITOR DIBENZAZEPINE Sulfanilamide Deionized water N,N'-Ethylenebis(stearamide) 2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol DAPT

  • γ-Secretase Inhibitor XXI
  • N-[(1S)-2-[[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide
  • CoMpound E (secretase inhibitor)
  • DuPont E
  • g-Secretase Inhibitor XXI
  • γ-Secretase Inhibitor BZ
  • (S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S,Z)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanamide
  • (S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanamide
  • StemSelect Compound E - CAS 209986-17-4 - Calbiochem
  • BZ, γ-Secretase Inhibitor - Compound E
  • Compound E (γ-Secretase Inhibitor XXI)
  • Benzeneacetamide, N-[(1S)-2-[[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-
  • γ-Secretase Inhibitor BZ
  • γ-Secretase Inhibitor XXI
  • Compound E, gamma
  • -secretase inhibitor
  • 209986-17-4
  • C27H24F2N4O3