γ-Secretase Inhibitor XXI

Product Name: γ-Secretase Inhibitor XXI
CAS No.: 209986-17-4
Chemical Name: γ-Secretase Inhibitor XXI
Synonyms: DuPont E;γ-Secretase-IN-1;Compound E, gamma;-secretase inhibitor;γ-Secretase Inhibitor BZ;γ-Secretase Inhibitor BZ;γ-Secretase Inhibitor XXI;g-Secretase Inhibitor XXI;γ-Secretase Inhibitor XXI;Compound E (γ-Secretase-IN-1)
CBNumber: CB42602844
Molecular Formula: C27H24F2N4O3
Formula Weight: 490.5
MOL File: 209986-17-4.mol

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γ-Secretase Inhibitor XXI Property

Boiling point:: 778.6±60.0 °C(Predicted)
Density: 1.31
storage temp.: = -70C
solubility: Soluble in DMSO
form: Liquid
pka: 12.54±0.40(Predicted)
color: White to off-white
Sensitive: Light Sensitive

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 565790
Product name: γ-Secretase Inhibitor XXI, Compound E - CAS 209986-17-4 - Calbiochem
Purity: Thisg-secretaseinhibitor,CAS209986-17-4,isacell-permeable,potent,select
Packaging: 500μg
Price: $345
Updated: 2024/03/01

Sigma-Aldrich

Product number: 565790
Product name: γ-Secretase Inhibitor XXI, Compound E - CAS 209986-17-4 - Calbiochem
Packaging: 1mg
Price: $445
Updated: 2024/03/01

Sigma-Aldrich

Product number: 5.30509
Product name: StemSelect Compound E - CAS 209986-17-4 - Calbiochem
Packaging: 250μg
Price: $209
Updated: 2024/03/01

Alfa Aesar

Product number: J65131
Product name: Compound E
Packaging: 0.5mg
Price: $307
Updated: 2023/06/20

Cayman Chemical

Product number: 15579
Product name: Compound E
Purity: ≥98%
Packaging: 500μg
Price: $189
Updated: 2024/03/01

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γ-Secretase Inhibitor XXI Chemical Properties,Usage,Production

Uses

A cell-permeable, potent, selective, peptidomimetic, non-transition-state analog inhibitor of -secretase and Notch processing

Definition

ChEBI: Compound E is an L-alanine derivative that is the amide obtained by formal condensation of the carboxy group of N-[(3,5-difluorophenyl)acetyl]-L-alanine with the amino group of (3S)-3-amino-1-methyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one. An inhibitor of memapsin 2 (gamma-secretase). It has a role as an EC 3.4.23.46 (memapsin 2) inhibitor. It is a 1,4-benzodiazepinone, a L-alanine derivative and a difluorobenzene.

storage

+4°C

γ-Secretase Inhibitor XXI Preparation Products And Raw materials

Raw materials

Preparation Products

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γ-Secretase Inhibitor XXI Suppliers

China 50 United Kingdom 2 United States 12 Global 64

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209986-17-4, γ-Secretase Inhibitor XXIRelated Search:

BETA-SECRETASE INHIBITOR IV DAPM GAMMA-SECRETASE INHIBITOR DIBENZAZEPINE Sulfanilamide Deionized water N,N'-Ethylenebis(stearamide) 2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol DAPT

γ-Secretase Inhibitor XXI

N-[(1S)-2-[[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide

CoMpound E (secretase inhibitor)

DuPont E

g-Secretase Inhibitor XXI

γ-Secretase Inhibitor BZ

(S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S,Z)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanamide

(S)-2-(2-(3,5-difluorophenyl)acetamido)-N-((S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)propanamide

StemSelect Compound E - CAS 209986-17-4 - Calbiochem

BZ, γ-Secretase Inhibitor - Compound E

Compound E (γ-Secretase Inhibitor XXI)

Benzeneacetamide, N-[(1S)-2-[[(3S)-2,3-dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluoro-

γ-Secretase Inhibitor BZ

γ-Secretase Inhibitor XXI

Compound E, gamma

-secretase inhibitor

γ-Secretase-IN-1

Compound E (γ-Secretase-IN-1)

(2S)-2-[2-(3,5-difluorophenyl)acetamido]-N-[(3S)-1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl]propanamide

209986-17-4

C27H24F2N4O3