JAK3 INHIBITOR I

Product Name: JAK3 INHIBITOR I
CAS No.: 202475-60-3
Chemical Name: JAK3 INHIBITOR I
Synonyms: CS-2623;Janex 1;WHI-P131;WHI-P131, >98%;JAK3 INHIBITOR I;JANEX-1;WHI-P131;WHI-P131(Janex 1);A JAK3 inhibitor WHI-P131;WHIP-131;JANEX-1);WHIP131;JANEX1;4-(6,7-dimethoxyquinazolin-4-ylamino)phenol
CBNumber: CB7130537
Molecular Formula: C16H15N3O3
Formula Weight: 297.31
MOL File: 202475-60-3.mol

More

Less

JAK3 INHIBITOR I Property

Boiling point:: 468.1±40.0 °C(Predicted)
Density: 1.336±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: DMSO: 18 mg/mL, soluble
form: solid
pka: 10.06±0.26(Predicted)
color: yellow
Stability:: Stable for 2 years from date of purchase as supplied. Protect from moisture. Solutions in DMSO may be stored at -20°C for up to 2 months.

More

Less

Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 420101
Product name: JAK3 Inhibitor I - CAS 202475-60-3 - Calbiochem
Packaging: 5MG
Price: $216
Updated: 2024/03/01

Cayman Chemical

Product number: 10011246
Product name: WHI-P131
Purity: ≥98%
Packaging: 1mg
Price: $31
Updated: 2024/03/01

Cayman Chemical

Product number: 10011246
Product name: WHI-P131
Purity: ≥98%
Packaging: 5mg
Price: $133
Updated: 2024/03/01

Cayman Chemical

Product number: 10011246
Product name: WHI-P131
Purity: ≥98%
Packaging: 10mg
Price: $234
Updated: 2024/03/01

Cayman Chemical

Product number: 10011246
Product name: WHI-P131
Purity: ≥98%
Packaging: 25mg
Price: $510
Updated: 2024/03/01

More

Less

JAK3 INHIBITOR I Chemical Properties,Usage,Production

Description

WHI-P131 (202475-60-3) is a JAK3 inhibitor.?Inhibits human glioblastoma cell adhesion and invasion.1 Increases survival in a mouse ALS model.2 Delays or prevents autoimmune type 1 diabetes in NOD mice.3 Exhibits potent anti-inflammatory activity in mouse models of peritonitis, colitis, cellulitis and systemic inflammatory response syndrome.4 Displays protective effects against myocardial ischemia and reperfusion injury in mouse models.5

Uses

Janex 1 is a Janus tyrosine kinase 3 (JAK3) inhibitor. Inhibition of JAK3 has been shown to exhibit protective action against the development of T1D in non-obese diabetic (NOD) mice. Janex 1 has been shown to suppresses proliferation of short-term cultured NOD CD4+ T cells through induction of apoptosis, while promoting survival of a particular population of long-term cultured cells. It ameliorates the expression of TNF-α-induced cell adhesion molecules and improves myocardial vascular permeability.

References

1) Narla et al. (1998), Inhibition of human glioblastoma cell adhesion and invasion by 4-(4’-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P131) and 4-(3’-bromo-4’-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P154); Mol. Clin. Cancer Res., 4 2463 2) Trieu et al. (2000), A specific inhibitor of janus kinase-3 increases survival in a transgenic mouse model of amyotrophic lateral sclerosis; Biochem. Biophys. Res. Commun., 267 22 3) Cetkovic-Cvrlje et al. (2003), Targeting JAK3 with JANEX-1 for prevention of autoimmune type 1 diabetes in NOD mice; Clin. Immunol., 106 213 4) Uckun et al. (2008), Anti-inflammatory activity profile of JANEX-1 in preclinical animal models; Bioorg. Med. Chem., 16 1287 5) Oh et al. (2013), Inhibition of Janus activated kinase-3 protects against myocardial ischemia and reperfusion injury in mice; Exp. Mol. Med., 45 e23

JAK3 INHIBITOR I Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

JAK3 INHIBITOR I Suppliers

China 95 Europe 1 India 2 Japan 2 United Kingdom 2 United States 23 Global 125

Angel Pharmatech, Ltd.

Tel: 17317130613
Fax: QQ3358272972
Email: 3358272972@qq.com
Country: China
ProdList: 3251
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Haoyuan Chemexpress Co., Ltd.

Tel: 021-58950125
Fax: (86) 21-58955996
Email: info@chemexpress.com
Country: China
ProdList: 7552
Advantage: 61

Shanghai Aladdin Bio-Chem Technology Co.,LTD

Tel: 400-400-6206333 18521732826
Fax: 021-50323701
Email: market@aladdin-e.com
Country: China
ProdList: 25003
Advantage: 65

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
Fax: +1 (866) 333-9607
Email: info@adooq.com
Country: United States
ProdList: 2782
Advantage: 58

Shanghai TaoSu Biochemical Technology Co., Ltd.

Tel: 021-33632979
Fax: 021-34692979
Email: info@tsbiochem.com
Country: China
ProdList: 8065
Advantage: 58

CEG Chemical Science&Technology Co., Ltd.

Tel: Mobile:13665161512
Fax: +86-510-68873513
Country: China
ProdList: 1785
Advantage: 58

ShangHai KenEn Chemical Technology Co., Ltd.

Tel: 13120367189
Fax: 021-50315529
Email: mychess007@163.com
Country: China
ProdList: 1994
Advantage: 55

More

Less

View Lastest Price from JAK3 INHIBITOR I manufacturers

Career Henan Chemical Co

Product: 4-(4'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE 202475-60-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20kg
Release date: 2019-09-05

202475-60-3, JAK3 INHIBITOR IRelated Search:

Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- Acetaminophen 2'-Hydroxyacetophenone Dihydroxybenzoic acid 2-HYDROXYACETOPHENONE 7-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE WH-4-023 4-AMINO-3-CYANO-1,2,5,6-TETRAHYDROPYRIDINE 4-(3'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE, HCL JAK3 Inhibitor WHI-P97 JAK3 INHIBITOR II JAK3 INHIBITOR, NEGATIVE CONTROL JAK3 INHIBITOR I JAK3 INHIBITOR VI JAK3 INHIBITOR IV JAK2 INHIBITOR II JAK3 INHIBITOR V

4-(4'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE

JAK3 INHIBITOR I

WHI-P131

Janex 1

A JAK3 inhibitor WHI-P131

4-(6,7-dimethoxyquinazolin-4-ylamino)phenol

WHI-P131(Janex 1)

JANEX-1;WHI-P131

WHIP-131;JANEX-1);WHIP131;JANEX1

CS-2623

WHI-P131, >98%

Phenol, 4-[(6,7-dimethoxy-4-quinazolinyl)amino]-

202475-60-3

Non-Receptor Tyrosine Kinase Inhibitors

Kinase/Phosphatase Biology

Janus Kinase (JAK)

BioChemical

Cell Biology

Cell Signaling and Neuroscience

Inhibitors

Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals