JAK3 INHIBITOR I
- Product Name
- JAK3 INHIBITOR I
- CAS No.
- 202475-60-3
- Chemical Name
- JAK3 INHIBITOR I
- Synonyms
- CS-2623;Janex 1;WHI-P131;WHI-P131, >98%;JAK3 INHIBITOR I;JANEX-1;WHI-P131;WHI-P131(Janex 1);A JAK3 inhibitor WHI-P131;WHIP-131;JANEX-1);WHIP131;JANEX1;4-(6,7-dimethoxyquinazolin-4-ylamino)phenol
- CBNumber
- CB7130537
- Molecular Formula
- C16H15N3O3
- Formula Weight
- 297.31
- MOL File
- 202475-60-3.mol
JAK3 INHIBITOR I Property
- Boiling point:
- 468.1±40.0 °C(Predicted)
- Density
- 1.336±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- DMSO: 18 mg/mL, soluble
- form
- solid
- pka
- 10.06±0.26(Predicted)
- color
- yellow
- Stability:
- Stable for 2 years from date of purchase as supplied. Protect from moisture. Solutions in DMSO may be stored at -20°C for up to 2 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 420101
- Product name
- JAK3 Inhibitor I - CAS 202475-60-3 - Calbiochem
- Packaging
- 5MG
- Price
- $216
- Updated
- 2024/03/01
- Product number
- 10011246
- Product name
- WHI-P131
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $31
- Updated
- 2024/03/01
- Product number
- 10011246
- Product name
- WHI-P131
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $133
- Updated
- 2024/03/01
- Product number
- 10011246
- Product name
- WHI-P131
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $234
- Updated
- 2024/03/01
- Product number
- 10011246
- Product name
- WHI-P131
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $510
- Updated
- 2024/03/01
JAK3 INHIBITOR I Chemical Properties,Usage,Production
Description
WHI-P131 (202475-60-3) is a JAK3 inhibitor.?Inhibits human glioblastoma cell adhesion and invasion.1 Increases survival in a mouse ALS model.2 Delays or prevents autoimmune type 1 diabetes in NOD mice.3 Exhibits potent anti-inflammatory activity in mouse models of peritonitis, colitis, cellulitis and systemic inflammatory response syndrome.4 Displays protective effects against myocardial ischemia and reperfusion injury in mouse models.5
Uses
Janex 1 is a Janus tyrosine kinase 3 (JAK3) inhibitor. Inhibition of JAK3 has been shown to exhibit protective action against the development of T1D in non-obese diabetic (NOD) mice. Janex 1 has been shown to suppresses proliferation of short-term cultured NOD CD4+ T cells through induction of apoptosis, while promoting survival of a particular population of long-term cultured cells. It ameliorates the expression of TNF-α-induced cell adhesion molecules and improves myocardial vascular permeability.
References
1) Narla et al. (1998), Inhibition of human glioblastoma cell adhesion and invasion by 4-(4’-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P131) and 4-(3’-bromo-4’-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P154); Mol. Clin. Cancer Res., 4 2463 2) Trieu et al. (2000), A specific inhibitor of janus kinase-3 increases survival in a transgenic mouse model of amyotrophic lateral sclerosis; Biochem. Biophys. Res. Commun., 267 22 3) Cetkovic-Cvrlje et al. (2003), Targeting JAK3 with JANEX-1 for prevention of autoimmune type 1 diabetes in NOD mice; Clin. Immunol., 106 213 4) Uckun et al. (2008), Anti-inflammatory activity profile of JANEX-1 in preclinical animal models; Bioorg. Med. Chem., 16 1287 5) Oh et al. (2013), Inhibition of Janus activated kinase-3 protects against myocardial ischemia and reperfusion injury in mice; Exp. Mol. Med., 45 e23
JAK3 INHIBITOR I Preparation Products And Raw materials
Raw materials
Preparation Products
JAK3 INHIBITOR I Suppliers
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View Lastest Price from JAK3 INHIBITOR I manufacturers
- Product
- 4-(4'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE 202475-60-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 20kg
- Release date
- 2019-09-05