JAK3 INHIBITOR I

Product Name: JAK3 INHIBITOR I
CAS No.: 202475-60-3
Chemical Name: JAK3 INHIBITOR I
Synonyms: CS-2623;Janex 1;WHI-P131;WHI-P131, >98%;JAK3 INHIBITOR I;JANEX-1;WHI-P131;WHI-P131(Janex 1);A JAK3 inhibitor WHI-P131;WHIP-131;JANEX-1);WHIP131;JANEX1;4-(6,7-dimethoxyquinazolin-4-ylamino)phenol
CBNumber: CB7130537
Molecular Formula: C16H15N3O3
Formula Weight: 297.31
MOL File: 202475-60-3.mol

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JAK3 INHIBITOR I Property

Boiling point:: 468.1±40.0 °C(Predicted)
Density: 1.336±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: DMSO: 18 mg/mL, soluble
form: solid
pka: 10.06±0.26(Predicted)
color: yellow
Stability:: Stable for 2 years from date of purchase as supplied. Protect from moisture. Solutions in DMSO may be stored at -20°C for up to 2 months.

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 420101
Product name: JAK3 Inhibitor I - CAS 202475-60-3 - Calbiochem
Packaging: 5MG
Price: $216
Updated: 2024/03/01

Cayman Chemical

Product number: 10011246
Product name: WHI-P131
Purity: ≥98%
Packaging: 1mg
Price: $31
Updated: 2024/03/01

Cayman Chemical

Product number: 10011246
Product name: WHI-P131
Purity: ≥98%
Packaging: 5mg
Price: $133
Updated: 2024/03/01

Cayman Chemical

Product number: 10011246
Product name: WHI-P131
Purity: ≥98%
Packaging: 10mg
Price: $234
Updated: 2024/03/01

Cayman Chemical

Product number: 10011246
Product name: WHI-P131
Purity: ≥98%
Packaging: 25mg
Price: $510
Updated: 2024/03/01

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JAK3 INHIBITOR I Chemical Properties,Usage,Production

Description

WHI-P131 (202475-60-3) is a JAK3 inhibitor.?Inhibits human glioblastoma cell adhesion and invasion.1 Increases survival in a mouse ALS model.2 Delays or prevents autoimmune type 1 diabetes in NOD mice.3 Exhibits potent anti-inflammatory activity in mouse models of peritonitis, colitis, cellulitis and systemic inflammatory response syndrome.4 Displays protective effects against myocardial ischemia and reperfusion injury in mouse models.5

Uses

Janex 1 is a Janus tyrosine kinase 3 (JAK3) inhibitor. Inhibition of JAK3 has been shown to exhibit protective action against the development of T1D in non-obese diabetic (NOD) mice. Janex 1 has been shown to suppresses proliferation of short-term cultured NOD CD4+ T cells through induction of apoptosis, while promoting survival of a particular population of long-term cultured cells. It ameliorates the expression of TNF-α-induced cell adhesion molecules and improves myocardial vascular permeability.

References

1) Narla et al. (1998), Inhibition of human glioblastoma cell adhesion and invasion by 4-(4’-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P131) and 4-(3’-bromo-4’-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P154); Mol. Clin. Cancer Res., 4 2463 2) Trieu et al. (2000), A specific inhibitor of janus kinase-3 increases survival in a transgenic mouse model of amyotrophic lateral sclerosis; Biochem. Biophys. Res. Commun., 267 22 3) Cetkovic-Cvrlje et al. (2003), Targeting JAK3 with JANEX-1 for prevention of autoimmune type 1 diabetes in NOD mice; Clin. Immunol., 106 213 4) Uckun et al. (2008), Anti-inflammatory activity profile of JANEX-1 in preclinical animal models; Bioorg. Med. Chem., 16 1287 5) Oh et al. (2013), Inhibition of Janus activated kinase-3 protects against myocardial ischemia and reperfusion injury in mice; Exp. Mol. Med., 45 e23

JAK3 INHIBITOR I Preparation Products And Raw materials

Raw materials

Preparation Products

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JAK3 INHIBITOR I Suppliers

China 95 Europe 1 India 2 Japan 2 United Kingdom 2 United States 23 Global 125

Angel Pharmatech, Ltd.

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View Lastest Price from JAK3 INHIBITOR I manufacturers

Career Henan Chemical Co

Product: 4-(4'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE 202475-60-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 20kg
Release date: 2019-09-05

202475-60-3, JAK3 INHIBITOR IRelated Search:

Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- Acetaminophen 2'-Hydroxyacetophenone Dihydroxybenzoic acid 2-HYDROXYACETOPHENONE 7-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE WH-4-023 4-AMINO-3-CYANO-1,2,5,6-TETRAHYDROPYRIDINE 4-(3'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE, HCL JAK3 Inhibitor WHI-P97 JAK3 INHIBITOR II JAK3 INHIBITOR, NEGATIVE CONTROL JAK3 INHIBITOR I JAK3 INHIBITOR VI JAK3 INHIBITOR IV JAK2 INHIBITOR II JAK3 INHIBITOR V

4-(4'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE

JAK3 INHIBITOR I

WHI-P131

Janex 1

A JAK3 inhibitor WHI-P131

4-(6,7-dimethoxyquinazolin-4-ylamino)phenol

WHI-P131(Janex 1)

JANEX-1;WHI-P131

WHIP-131;JANEX-1);WHIP131;JANEX1

CS-2623

WHI-P131, >98%

Phenol, 4-[(6,7-dimethoxy-4-quinazolinyl)amino]-

202475-60-3

Non-Receptor Tyrosine Kinase Inhibitors

Kinase/Phosphatase Biology

Janus Kinase (JAK)

BioChemical

Cell Biology

Cell Signaling and Neuroscience

Inhibitors

Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals