LY-2584702 (hydrochloride)

Product Name: LY-2584702 (hydrochloride)
CAS No.: 1082948-81-9
Chemical Name: LY-2584702 (hydrochloride)
Synonyms: LY2584702 HCl;LY-2584702 (hydrochloride);LY-2584702 hydrochloride (LY2584702);LY 2584702 hydrochloride,LY2584702 hydrochloride;4-[4-[4-[4-Fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine hydrochloride (1:1)
CBNumber: CB22735526
Molecular Formula: C21H20ClF4N7
Formula Weight: 481.88
MOL File: 1082948-81-9.mol

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LY-2584702 (hydrochloride) Property

storage temp.: Store at -20°C
solubility: Soluble in DMSO

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Safety

HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Apolloscientific

Product number: BISN0269
Product name: LY2584702 Hydrochloride
Packaging: 5mg
Price: $102
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611835
Product name: LY-2584702 hydrochloride
Packaging: 10mg
Price: $272
Updated: 2021/12/16

Apolloscientific

Product number: BISN0269
Product name: LY2584702 Hydrochloride
Packaging: 25mg
Price: $311
Updated: 2021/12/16

Apolloscientific

Product number: BISN0269
Product name: LY2584702 Hydrochloride
Packaging: 50mg
Price: $527
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611835
Product name: LY-2584702 hydrochloride
Packaging: 50mg
Price: $584.8
Updated: 2021/12/16

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LY-2584702 (hydrochloride) Chemical Properties,Usage,Production

Uses

LY-2584702 hydrochloride is a selective ATP competitive inhibitor of p70S6K with an IC50 of 4 nM. In S6K1 enzyme assay, the IC50 of LY-2584702 is 2 nM.

in vivo

LY-2584702 demonstrates significant single-agent efficacy in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models at two dose levels of 2.5 mg/kg twice daily (BID) and 12.5 mg/kg BID. LY-2584702 demonstrates statistically significant tumour growth reduction at TMED50 (threshold minimum effective dose 50%) (2.3 mg/kg) and TMED90 (10 mg/kg) in the HCT116 colon carcinoma xenograft model^[1]. To examine the role of S6K in vivo, EOMA cells expressing shAkt3 are implanted in nu/nu mice, then treated for 14 days with LY-2584702 or Rapamycin. Analysis of tumors removed after 14 days shows that LY-2584702 inhibits S6 phosphorylation almost as effectively as Rapamycin. Loss of Akt3 increases tumor growth as compared with pLKO. LY-2584702 treatment alone does not significantly affect the growth of pLKO tumors. However, LY-2584702 significantly reduces the growth of tumors with shAkt3^[2].

IC 50

p70S6K: 4 nM (IC₅₀)

References

[1] Tolcher A, et al. A phase I trial of LY2584702 tosylate, a p70 S6 kinase inhibitor, in patients with advanced solid tumors. Eur J Cancer. 2014 Mar;50(5):867-75. DOI:10.1016/j.ejca.2013.11.039
[2] Phung TL, et al. Akt1 and akt3 exert opposing roles in the regulation of vascular tumor growth. Cancer Res. 2015 Jan 1;75(1):40-50. DOI:10.1158/0008-5472.CAN-13-2961
[3] Chen B, et al. Hyperphosphorylation of RPS6KB1, rather than overexpression, predicts worse prognosis in non-small cell lung cancer patients. PLoS One. 2017 Aug 9;12(8):e0182891. DOI:10.1371/journal.pone.0182891

LY-2584702 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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LY-2584702 (hydrochloride) Suppliers

China 19 United States 5 Global 24

Shanghai Boyle Chemical Co., Ltd.

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Sichuan Wei Keqi Biological Technology Co., Ltd.

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Suzhou yacoo science co.,Ltd

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LETOPHARM LIMITED

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ShangHai Biochempartner Co.,Ltd

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Amadis Chemical Company Limited

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Medi-tech Bioscientific Co., Ltd.

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Musechem

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Fan De(Beijing) Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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