ChemicalBook > CAS DataBase List > 2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide

2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide

Product Name
2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide
CAS No.
313254-51-2
Chemical Name
2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide
Synonyms
ICA-121431;ICA-121431 >=98% (HPLC);ICA-121431;ICA 121431;ICA121431;2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl;2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide;2,2-DIPHENYL-N-(4-(N-THIAZOL-2-YLSULFAMOYL)PHENYL) ACETAMIDE;α-Phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-benzeneacetamide;Benzeneacetamide, α-phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-;alpha-Phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]benzeneacetamide;Nav,Na channels,inhibitor,ICA-121431,ICA 121431,TTX-resistant,Sodium Channel,channel,Na+ channels,ICA121431,inhibit
CBNumber
CB22737166
Molecular Formula
C23H19N3O3S2
Formula Weight
449.55
MOL File
313254-51-2.mol
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2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide Property

Density 
1.409±0.06 g/cm3(Predicted)
storage temp. 
room temp
solubility 
DMSO: soluble20mg/mL, clear
pka
7.03±0.10(Predicted)
form 
powder
color 
white to beige
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey
URSQNPPONHUJDL-UHFFFAOYSA-N
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36
Safety Statements 
26
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H319Causes serious eye irritation

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1035
Product name
ICA-121431
Purity
≥98% (HPLC)
Packaging
5mg
Price
$120
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1035
Product name
ICA-121431
Purity
≥98% (HPLC)
Packaging
25mg
Price
$190.4
Updated
2024/03/01
Cayman Chemical
Product number
24669
Product name
ICA 121431
Purity
≥98%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
24669
Product name
ICA 121431
Purity
≥98%
Packaging
5mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
24669
Product name
ICA 121431
Purity
≥98%
Packaging
10mg
Price
$199
Updated
2024/03/01
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2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide Chemical Properties,Usage,Production

Description

ICA 121431 is a voltage-gated sodium channel (Nav) blocker that selectively blocks Nav1.1 and Nav1.3 over Nav1.4, and Nav1.5-1.8 channels (IC50s = <20, 19, 240, and >10,000 nM, respectively). It induces a concentration-dependent hyperpolarizing shift in voltage dependence of inactivation of Nav1.3 channels at a concentration 1 μM but has no effect on resting channels. Substitution of the Nav1.3 domain IV voltage-sensor domain (VSD4) with the Nav1.5 VSD4 reduces ICA 121431 potency by approximately 500-fold.

Uses

ICA 121431 is a voltage-gated sodium (Nav) channel inhibitor.

storage

+4°C

References

McCormack et al. (2013), Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels; Proc. Natl. Acad. Sci. USA 110 E2724 Ostenn et al. (2017), Pharmacology of the Nav1.1 domain IV voltage sensor reveals coupling between inactivation gating processes; Proc. Natl. Acad. Sci. USA 114 6836

2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

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2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide Suppliers

China 41 United Kingdom 1 United States 11 Global 53
Shanghai Boyle Chemical Co., Ltd.
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MedChemexpress LLC
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View Lastest Price from 2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide manufacturers

Career Henan Chemical Co
Product
Benzeneacetamide, α-?phenyl-?N-?[4-?[(2-?thiazolylamino)?sulfonyl]?phenyl]?- 313254-51-2
Price
US $0.01/KG
Min. Order
1KG
Purity
98%; 99%
Supply Ability
500g;1kg； 25kg
Release date
2020-01-09

313254-51-2, 2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamideRelated Search:

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  • ICA-121431
  • 2,2-DIPHENYL-N-(4-(N-THIAZOL-2-YLSULFAMOYL)PHENYL) ACETAMIDE
  • 2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl)-phenyl]-acetamide
  • α-Phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-benzeneacetamide
  • alpha-Phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]benzeneacetamide
  • ICA-121431;ICA 121431;ICA121431
  • Benzeneacetamide, α-phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]-
  • 2,2-Diphenyl-N-[4-(thiazol-2-ylsulfamoyl
  • ICA-121431 >=98% (HPLC)
  • Nav,Na channels,inhibitor,ICA-121431,ICA 121431,TTX-resistant,Sodium Channel,channel,Na+ channels,ICA121431,inhibit
  • 313254-51-2