ABBV-075

Product Name: ABBV-075
CAS No.: 1445993-26-9
Chemical Name: ABBV-075
Synonyms: Mivebresib;5100;Mivibus;CS-2464;CS-2213;ABBV-075;Mivebresib (ABBV-075 );Mivebresib, 10 mM in DMSO;ABBV-075; ABBV075; ABBV 075;Terbufos Impurity 12 (Vamidothion)
CBNumber: CB22738567
Molecular Formula: C22H19F2N3O4S
Formula Weight: 459.47
MOL File: 1445993-26-9.mol

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ABBV-075 Property

Boiling point:: 608.9±65.0 °C(Predicted)
Density: 1.465±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:60.0(Max Conc. mg/mL);130.59(Max Conc. mM)
form: A crystalline solid
pka: 8.37±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H320Causes eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21033
Product name: ABBV-075
Purity: ≥98%
Packaging: 500μg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 21033
Product name: ABBV-075
Purity: ≥98%
Packaging: 1mg
Price: $61
Updated: 2024/03/01

Cayman Chemical

Product number: 21033
Product name: ABBV-075
Purity: ≥98%
Packaging: 5mg
Price: $169
Updated: 2024/03/01

Cayman Chemical

Product number: 21033
Product name: ABBV-075
Purity: ≥98%
Packaging: 10mg
Price: $305
Updated: 2024/03/01

ChemScene

Product number: CS-5815
Product name: Mivebresib
Purity: 99.69%
Packaging: 50mg
Price: $540
Updated: 2021/12/16

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ABBV-075 Chemical Properties,Usage,Production

Uses

ABBV 075-d5 is a deuterium labelled ABBV 075 (A215280), which is used for selective inhibition of the BD2 bromodomain of bromodomain and extra-??terminal proteins in prostate cancer.

Biological Activity

Mivebresib (ABBV-075) is a novel BET family bromodomain inhibitor. Binds to the bromodomain of BRD2/4/T with similar affinity (Ki values between 1-2.2 nM) with high selectivity. Low potency against BRD3 (Ki=12.2 nM) and moderate activity against CREBBP (Ki=87 μM). It can effectively trigger apoptosis in a variety of tumor cells.

in vitro

ABBV-075 has potent and potent single-agent activity in a variety of cancer cell lines (from solid tumors, leukemias and lymphomas) in cell viability assays. It is capable of disrupting cell cycle control, leading to G1 arrest, further senescence, inhibition of tumor formation, induction of apoptosis, and possibly targeting the tumor microenvironment to further provide better efficacy.

in vivo

In mouse models laterally xenografted with non-small cell and small cell lung cancer, pancreatic cancer, breast cancer, prostate cancer, head and neck cancer, multiple lymphomas, diffuse giant B-cell lymphoma, and leukemia, ABBV -075 has equal or better efficacy than other standard care agents.

target

Target	Value
BRD2
BRD4
BRD-T

ABBV-075 Preparation Products And Raw materials

Raw materials

Preparation Products

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ABBV-075 Suppliers

China 96 India 1 United States 9 Global 106

Changzhou Chenhong Biotechnology Co., Ltd.

Tel: 0519-85788828 13775037613
Email: sales@chemrenpharm.com
Country: China
ProdList: 3600
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3466
Advantage: 58

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4573
Advantage: 55

Shanghai Synchem Pharma Co., ltd

Tel: 21-619849051-1 18521059765
Email: synchempharma@aliyun.com
Country: China
ProdList: 6464
Advantage: 55

NanJing Xienuo bio Co.,Ltd.

Tel: 025-84112752 13805181430
Fax: +86-25-84846489
Email: 154301870@qq.com
Country: China
ProdList: 1000
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Shanghai Rechem science Co., Ltd.

Tel: 21-31433387 15618786686
Fax: QQ:1369748377
Email: sales@rechemscience.com
Country: China
ProdList: 2998
Advantage: 58

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 7312
Advantage: 58

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View Lastest Price from ABBV-075 manufacturers

Career Henan Chemical Co

Product: ABBV-075 1445993-26-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2019-12-25

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N-(4-(2,4-difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide

ABBV-075

Mivebresib

5100

Mivebresib (ABBV-075 )

ABBV-075; ABBV075; ABBV 075

CS-2213

Mivebresib (ABBV075, ABBV-075, ABBV 075)

CS-2464

Mivibus

Ethanesulfonamide, N-[4-(2,4-difluorophenoxy)-3-(6,7-dihydro-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl]-

Terbufos Impurity 12 (Vamidothion)

Mivebresib, 10 mM in DMSO

1445993-26-9

2115742-03-0