ChemicalBook > CAS DataBase List > LSD1-IN-1

LSD1-IN-1

Product Name
LSD1-IN-1
CAS No.
1431326-61-2
Chemical Name
LSD1-IN-1
Synonyms
CS-1530;RG 6016;ORY-1001;LSD1-IN-1;RG6016) 2HCl;ORY-1001 (RG-6016);ORY-1001 2HCl salt;ORY-1001(LSD1-IN-1);Iadademstat (ORY-1001;ORY-1001 (RG-6016) 2HCl
CBNumber
CB22739120
Molecular Formula
C15H24Cl2N2
Formula Weight
303.27046
MOL File
1431326-61-2.mol
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LSD1-IN-1 Property

storage temp. 
Store at -20°C
solubility 
insoluble in EtOH; ≥23.15 mg/mL in H2O; ≥6.9 mg/mL in DMSO with gentle warming
form 
solid
CAS DataBase Reference
1431326-61-2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19136
Product name
ORY-1001
Purity
≥98%
Packaging
500μg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
19136
Product name
ORY-1001
Purity
≥98%
Packaging
1mg
Price
$61
Updated
2024/03/01
Cayman Chemical
Product number
19136
Product name
ORY-1001
Purity
≥98%
Packaging
5mg
Price
$230
Updated
2024/03/01
Cayman Chemical
Product number
19136
Product name
ORY-1001
Purity
≥98%
Packaging
10mg
Price
$426
Updated
2024/03/01
TRC
Product number
O671003
Product name
ORY-1001
Packaging
10mg
Price
$470
Updated
2021/12/16
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LSD1-IN-1 Chemical Properties,Usage,Production

Description

Lysine-specific demethylase 1 (LSD1) demethylates H3K4 and H3K9, resulting in transcriptional repression. It also controls the tumor suppressor activity of p53 by demethylating a specific p53 lysine residue (LYS370). ORY-1001 is an orally available, selective inhibitor of LSD1 (IC50 < 20 nM). It targets acute myeloid leukemia (AML) stem cells and significantly reduces tumor cell load while increasing survival time in mouse models of AML. ORY-1001 is in clinical trials for cancer treatment.

Uses

ORY-1001 is a potent LSD1 inhibitor.

in vitro

ory-1001 is an enantiomerically pure kdm1a inhibitor with high selectivity against related fad dependent aminoxidases. ory-1001 does not inhibit non-related histone modifiers, and is clean in a cerep diversity panel. treatment of thp-1 cells with ory-1001, results in a time/dose dependent me2h3k4 accumulation at kdm1a target genes and concomitant induction of differentiation markers [1].

in vivo

daily oral administration of doses < 0.020 mg/kg leads to significantly reduced tumor growth in rodent xenografts. in vivo studies have shown that ory-1001 presents excellent oral bioavailability, target exposure and activity in vivo [1].

IC 50

<20nm

LSD1-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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LSD1-IN-1 Suppliers

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View Lastest Price from LSD1-IN-1 manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
LSD1-IN-1 1431326-61-2
Price
US $0.10/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
1000 tons
Release date
2020-04-24
Shaanxi Dideu Medichem Co. Ltd
Product
LSD1-IN-1 1431326-61-2
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%+
Supply Ability
100 tons
Release date
2020-01-15

1431326-61-2, LSD1-IN-1Related Search:

Indium

  • rel-N1-[(1R,2S)-2-Phenylcyclopropyl]-1,4-cyclohexanediamine hydrochloride (1:2)
  • LSD1-IN-1
  • ORY-1001
  • ORY-1001 (RG-6016)
  • RG 6016
  • ORY-1001 2HCl salt
  • RG 6016;RG6016;RG-6016;ORY1001;ORY 1001
  • ORY-1001 trans and cis isomers
  • rel-N1-[(1R,2S)-2-Phenylcyclopropyl]-1,4-cyclohexanediamine hydrochloride
  • CS-1530
  • LSD1-IN-1;ORY1001;ORY 1001
  • ORY-1001(LSD1-IN-1)
  • ORY-1001 (RG-6016) 2HCl
  • Iadademstat (ORY-1001
  • RG6016) 2HCl
  • trans-N1-(2-Phenylcyclopropyl)cyclohexane-1,4-diamine dihydrochloride
  • Iadademstat (ORY-1001) 2HCl
  • Iadademstat (mixture of trans and cis isomers dihydrochloride)
  • RO 7051790 dihydrochloride
  • 1431326-61-2
  • 143126-61-2