LSD1-IN-1
- Product Name
- LSD1-IN-1
- CAS No.
- 1431326-61-2
- Chemical Name
- LSD1-IN-1
- Synonyms
- CS-1530;RG 6016;ORY-1001;LSD1-IN-1;RG6016) 2HCl;ORY-1001 (RG-6016);ORY-1001 2HCl salt;ORY-1001(LSD1-IN-1);Iadademstat (ORY-1001;ORY-1001 (RG-6016) 2HCl
- CBNumber
- CB22739120
- Molecular Formula
- C15H24Cl2N2
- Formula Weight
- 303.27046
- MOL File
- 1431326-61-2.mol
LSD1-IN-1 Property
- storage temp.
- Store at -20°C
- solubility
- insoluble in EtOH; ≥23.15 mg/mL in H2O; ≥6.9 mg/mL in DMSO with gentle warming
- form
- solid
- CAS DataBase Reference
- 1431326-61-2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 19136
- Product name
- ORY-1001
- Purity
- ≥98%
- Packaging
- 500μg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 19136
- Product name
- ORY-1001
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $61
- Updated
- 2024/03/01
- Product number
- 19136
- Product name
- ORY-1001
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $230
- Updated
- 2024/03/01
- Product number
- 19136
- Product name
- ORY-1001
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $426
- Updated
- 2024/03/01
- Product number
- O671003
- Product name
- ORY-1001
- Packaging
- 10mg
- Price
- $470
- Updated
- 2021/12/16
LSD1-IN-1 Chemical Properties,Usage,Production
Description
Lysine-specific demethylase 1 (LSD1) demethylates H3K4 and H3K9, resulting in transcriptional repression. It also controls the tumor suppressor activity of p53 by demethylating a specific p53 lysine residue (LYS370). ORY-1001 is an orally available, selective inhibitor of LSD1 (IC50 < 20 nM). It targets acute myeloid leukemia (AML) stem cells and significantly reduces tumor cell load while increasing survival time in mouse models of AML. ORY-1001 is in clinical trials for cancer treatment.
Uses
ORY-1001 is a potent LSD1 inhibitor.
in vitro
ory-1001 is an enantiomerically pure kdm1a inhibitor with high selectivity against related fad dependent aminoxidases. ory-1001 does not inhibit non-related histone modifiers, and is clean in a cerep diversity panel. treatment of thp-1 cells with ory-1001, results in a time/dose dependent me2h3k4 accumulation at kdm1a target genes and concomitant induction of differentiation markers [1].
in vivo
daily oral administration of doses < 0.020 mg/kg leads to significantly reduced tumor growth in rodent xenografts. in vivo studies have shown that ory-1001 presents excellent oral bioavailability, target exposure and activity in vivo [1].
IC 50
<20nm
LSD1-IN-1 Preparation Products And Raw materials
Raw materials
Preparation Products
LSD1-IN-1 Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from LSD1-IN-1 manufacturers
- Product
- LSD1-IN-1 1431326-61-2
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2020-04-24
- Product
- LSD1-IN-1 1431326-61-2
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%+
- Supply Ability
- 100 tons
- Release date
- 2020-01-15