ChemicalBook > CAS DataBase List > PU-WS13
PU-WS13
- Product Name
- PU-WS13
- CAS No.
- 1454619-14-7
- Chemical Name
- PU-WS13
- Synonyms
- PU-WS13;CS-2047;CS-1689;PU WS13;PUWS13;8-((3,5-dichlorophenyl)thio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine;8-(3,5-dichlorophenyl)sulfanyl-9-[3-(propan-2-ylamino)propyl]purin-6-amine;6-Amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine;9H-Purine-9-propanamine, 6-amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)-
- CBNumber
- CB22742078
- Molecular Formula
- C17H20Cl2N6S
- Formula Weight
- 411.35
- MOL File
- 1454619-14-7.mol
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PU-WS13 Property
- Boiling point:
- 617.4±65.0 °C(Predicted)
- Density
- 1.47±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- DMF: 30 mg/mL,DMSO: 30 mg/mL,DMSO:PBS(pH7.2) (1:1): 0.5 mg/mL,Ethanol: 25 mg/mL
- form
- Powder
- pka
- 10.15±0.29(Predicted)
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 18409
- Product name
- PU-WS13
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $36
- Updated
- 2022/04/27
Cayman Chemical
- Product number
- 18409
- Product name
- PU-WS13
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $91
- Updated
- 2022/04/27
Cayman Chemical
- Product number
- 18409
- Product name
- PU-WS13
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $143
- Updated
- 2022/04/27
Cayman Chemical
- Product number
- 18409
- Product name
- PU-WS13
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $269
- Updated
- 2022/04/27
TRC
- Product number
- P840335
- Product name
- PU-WS13
- Packaging
- 100mg
- Price
- $790
- Updated
- 2021/12/16
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PU-WS13 Chemical Properties,Usage,Production
Description
PU-WS13 is an inhibitor of the heat shock protein family member and chaperone protein glucose-regulated protein 94 (GRP94; IC50 = 0.22 μM). It is selective for GRP94 over the chaperones Hsp90α, Hsp90β, and TRAP1 (IC50s = 27.3, 41.8, and 7.3 μM, respectively). PU-WS13 (0.5, 2.5, and 12.5 μM) induces apoptosis without increasing Hsp70 protein levels in HER2-overexpressing SK-BR-3, BT474, and MDA-MB-361 breast cancer cells. It also induces apoptosis and necrosis in multiple myeloma cells but does not induces cell death in pre-B leukemic cells.
Uses
PU-WS13 is a pharmaceutical agent used in the preparation go paralog=selective HSP90 inhibitors used in anti-tumor treatments.
PU-WS13 Preparation Products And Raw materials
Raw materials
Preparation Products
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PU-WS13 Suppliers
- Tel
- Fax
- 86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2923
- Advantage
- 55
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7553
- Advantage
- 61
- Tel
- 021-58955995
- Fax
- 609-228-5909
- sales@medchemexpress.cn
- Country
- United States
- ProdList
- 4863
- Advantage
- 58
- Tel
- 0551-66399836 18955197623
- sales@enlipharma.com
- Country
- China
- ProdList
- 1874
- Advantage
- 55
- Tel
- 0571-82693216
- Fax
- 0571-82880190
- info@yuhaochemical.com
- Country
- China
- ProdList
- 2031
- Advantage
- 58
- Tel
- 021-18721936-595 18721936595
- Fax
- -
- shkylpharma@126.com
- Country
- China
- ProdList
- 685
- Advantage
- 55
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4153
- Advantage
- 55
- Tel
- 18068075658
- Fax
- -
- sales@chempioneer.com
- Country
- China
- ProdList
- 1811
- Advantage
- 58
- Tel
- 400-027-6116 18086000087
- Fax
- QQ: 2680733325
- sales@chemgreatwall.com
- Country
- China
- ProdList
- 1561
- Advantage
- 55
- Tel
- 020-61288194 61288195
- Fax
- 020-61288700
- 505721671@qq.com
- Country
- China
- ProdList
- 3868
- Advantage
- 58
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View Lastest Price from PU-WS13 manufacturers
Career Henan Chemical Co
- Product
- PU-WS13 1454619-14-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98-100%
- Supply Ability
- 1000kg
- Release date
- 2018-08-20