ChemicalBook > CAS DataBase List > 2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid hydroxyamide

2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid hydroxyamide

Product Name
2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid hydroxyamide
CAS No.
1375465-91-0
Chemical Name
2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid hydroxyamide
Synonyms
CS-2244;ACY-738;ACY 738; ACY738;ACY738;ACY-738;ACY 738;2-(1-phenylcyclopropylamino)-N-hydroxypyrimidine-5-carboxamide;N-Hydroxy-2-[(1-phenylcyclopropyl)amino]-5-pyrimidinecarboxamide;N-hydroxy-2-[(1-phenylcyclopropyl)amino]pyrimidine-5-carboxamide;5-Pyrimidinecarboxamide, N-hydroxy-2-[(1-phenylcyclopropyl)amino]-;2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid hydroxyamide
CBNumber
CB22742795
Molecular Formula
C14H14N4O2
Formula Weight
270.29
MOL File
1375465-91-0.mol
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2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid hydroxyamide Property

Density 
1.433±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:32.0(Max Conc. mg/mL);118.39(Max Conc. mM)
form 
A crystalline solid
pka
7.75±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28282
Product name
ACY-738
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
28282
Product name
ACY-738
Packaging
25mg
Price
$819
Updated
2024/03/01
Cayman Chemical
Product number
28282
Product name
ACY-738
Packaging
5mg
Price
$239
Updated
2024/03/01
Cayman Chemical
Product number
28282
Product name
ACY-738
Packaging
10mg
Price
$419
Updated
2024/03/01
ChemScene
Product number
CS-5149
Product name
ACY-738
Purity
98.75%
Packaging
5mg
Price
$120
Updated
2021/12/16
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2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid hydroxyamide Chemical Properties,Usage,Production

Description

ACY-738 is an inhibitor of histone deacetylase 6 (HDAC6; IC50 = 1.7 nM). It is selective for HDAC6 over HDAC1-3 (IC50s = 94, 128, and 218 nM, respectively). ACY-738 (5 mg/kg) increases acetylation of α-tubulin in mouse brain. It increases exploratory activity in a novel open-field test and reduces immobility time in a tail suspension test in wild-type, but not neural cell-selective HDAC6 knockout, mice when administered at a dose of 50 mg/kg, indicating anxiolytic and antidepressant-like activity, respectively. ACY-738 (100 mg/kg in the diet) attenuates decreases in caudal nerve sensory nerve action potential (SNAP) amplitude and increases in hind paw mechanical hypersensitivity in a mouse model of peripheral neuropathy induced by vincristine . It decreases hepatorenal cystogenesis in a rat model of polycystic liver disease when administered at a dose of 30 mg/kg.

2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid hydroxyamide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid hydroxyamide manufacturers

Career Henan Chemical Co
Product
2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid hydroxyamide 1375465-91-0
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2020-01-03

1375465-91-0, 2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid hydroxyamideRelated Search:

4-Aminodiphenylamine FORMANILIDE N-Methylbenzamide

  • 2-(1-Phenyl-cyclopropylamino)-pyrimidine-5-carboxylic acid hydroxyamide
  • ACY-738
  • N-Hydroxy-2-[(1-phenylcyclopropyl)amino]-5-pyrimidinecarboxamide
  • ACY 738; ACY738
  • 2-(1-phenylcyclopropylamino)-N-hydroxypyrimidine-5-carboxamide
  • ACY738;ACY-738;ACY 738
  • CS-2244
  • 5-Pyrimidinecarboxamide, N-hydroxy-2-[(1-phenylcyclopropyl)amino]-
  • N-hydroxy-2-[(1-phenylcyclopropyl)amino]pyrimidine-5-carboxamide
  • 1375465-91-0