ChemicalBook > CAS DataBase List > N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide

N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide

Product Name: N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide
CAS No.: 1333146-24-9
Chemical Name: N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide
Synonyms: CS-2064;CS-4936;ILK-IN-1;OSU-T315;GTPL8116;BDBM50353484;CHEMBL1830587;SCHEMBL8536228;OSU-T315 analog;OSU-T315 (OSU-T 315)
CBNumber: CB22743020
Molecular Formula: C30H30F3N5O
Formula Weight: 533.59
MOL File: 1333146-24-9.mol

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N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide Property

Boiling point:: 739.2±60.0 °C(Predicted)
Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 10mM
form: A solid
pka: 16.02±0.46(Predicted)
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-5471
Product name: ILK-IN-2
Purity: 99.41%
Packaging: 2mg
Price: $180
Updated: 2021/12/16

ChemScene

Product number: CS-5471
Product name: ILK-IN-2
Purity: 99.41%
Packaging: 5mg
Price: $380
Updated: 2021/12/16

ChemScene

Product number: CS-5471
Product name: ILK-IN-2
Purity: 99.41%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573462
Product name: OSU-T315
Purity: >98%
Packaging: 100mg
Price: $1133.9
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573462
Product name: OSU-T315
Purity: >98%
Packaging: 250mg
Price: $1802
Updated: 2021/12/16

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N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide Chemical Properties,Usage,Production

Uses

ILK-IN-2 (OSU-T315 analog) is an oral PDK2 inhibitor and also an ILK inhibitor, with an IC50 of 0.6 μM. ILK-IN-2 induces cell autophagy and apoptosis, showing anti-tumor activity. ILK-IN-2 directly abolishes AKT activation by preventing AKT from translocating to lipid rafts, triggering Caspase-dependent apoptosis in chronic lymphocytic leukemia (CLL) and extending the lifespan in TCL1 mouse models[1][2].

in vivo

ILK-IN-2 (25-50 mg/kg, oral or intraperitoneal injection, once daily, 2-4 weeks) delays leukemia progression in mice and significantly improves the overall survival rate of mice harboring TCL1 leukemia cells^{[ 1 ]}.
ILK-IN-2 (25-50 mg/kg, orally, daily, for 35 days) inhibits the growth of PC-3 xenograft tumors in nude mice^[2].

Animal Model:	Pharmacokinetic properties of OSU-T315^[1]
Dosage:	50 mg/kg, daily for 4 weeks; 25 mg/kg, once daily for 2 weeks
Administration:	Oral; Intraperitoneal injection (i.p.)
Result:	Reduced white blood cell count and prolonged the survival of mice.

Animal Model:	PC-3 tumor xenograft mice model^[2]
Dosage:	25, 50 mg/kg; daily; 35 days
Administration:	Oral
Result:	Significantly inhibited tumor growth (25 and 50 mg/kg groups inhibited 48% and 62% respectively). Showed that the phosphorylation of Ser-473-Akt was dose-dependently inhibited, while the phosphorylation of Thr-308-Akt was not affected. At the same time, the phosphorylation levels of GSK3β and MLC and the expression levels of YB-1, HER2 and EGFR also appeared in parallel decline.

IC 50

ILK: 0.6 μM (IC₅₀)

References

[1] Ta-Ming Liu, et al. OSU-T315: a novel targeted therapeutic that antagonizes AKT membrane localization and activation of chronic lymphocytic leukemia cells. Blood. 2015 Jan 8;125(2):284-95. DOI:10.1182/blood-2014-06-583518
[2] Su-Lin Lee, et al. Identification and characterization of a novel integrin-linked kinase inhibitor. J Med Chem. 2011 Sep 22;54(18):6364-74. DOI:10.1021/jm2007744

N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide Preparation Products And Raw materials

Raw materials

Preparation Products

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1333146-24-9, N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamideRelated Search:

N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide

ILK-IN-1

BDBM50353484

CHEMBL1830587

CS-4936

GTPL8116

SCHEMBL8536228

OSU-T315

CS-2064

1H-Pyrazole-3-propanamide, N-methyl-1-[4-(1-piperazinyl)phenyl]-5-[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-

ILK-IN-2 (CPD 22: OSU-T315 analog)

N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4-(trifluorometh

Integrin,inhibit,ILK IN 2,ILKIN2,Inhibitor

OSU-T315 analog

ILK-IN-2, 10 mM in DMSO

OSU-T315 (OSU-T 315)

1333146-24-9

C30H30F3N5O