ChemicalBook > CAS DataBase List > N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide

N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide

Product Name
N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide
CAS No.
1333146-24-9
Chemical Name
N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide
Synonyms
CS-2064;CS-4936;ILK-IN-1;OSU-T315;GTPL8116;BDBM50353484;CHEMBL1830587;SCHEMBL8536228;OSU-T315 analog;OSU-T315 (OSU-T 315)
CBNumber
CB22743020
Molecular Formula
C30H30F3N5O
Formula Weight
533.59
MOL File
1333146-24-9.mol
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N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide Property

Boiling point:
739.2±60.0 °C(Predicted)
Density 
1.27±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 10mM
form 
A solid
pka
16.02±0.46(Predicted)
color 
White to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-5471
Product name
ILK-IN-2
Purity
99.41%
Packaging
5mg
Price
$380
Updated
2021/12/16
ChemScene
Product number
CS-5471
Product name
ILK-IN-2
Purity
99.41%
Packaging
10mg
Price
$600
Updated
2021/12/16
ChemScene
Product number
CS-5471
Product name
ILK-IN-2
Purity
99.41%
Packaging
2mg
Price
$180
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573462
Product name
OSU-T315
Purity
>98%
Packaging
100mg
Price
$1133.9
Updated
2021/12/16
Biorbyt Ltd
Product number
orb573462
Product name
OSU-T315
Purity
>98%
Packaging
250mg
Price
$1802
Updated
2021/12/16
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N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide Chemical Properties,Usage,Production

Uses

ILK-IN-2 (OSU-T315 analog) is an oral PDK2 inhibitor and also an ILK inhibitor, with an IC50 of 0.6 μM. ILK-IN-2 induces cell autophagy and apoptosis, showing anti-tumor activity. ILK-IN-2 directly abolishes AKT activation by preventing AKT from translocating to lipid rafts, triggering Caspase-dependent apoptosis in chronic lymphocytic leukemia (CLL) and extending the lifespan in TCL1 mouse models[1][2].

in vivo

ILK-IN-2 (25-50 mg/kg, oral or intraperitoneal injection, once daily, 2-4 weeks) delays leukemia progression in mice and significantly improves the overall survival rate of mice harboring TCL1 leukemia cells[ 1 ].
ILK-IN-2 (25-50 mg/kg, orally, daily, for 35 days) inhibits the growth of PC-3 xenograft tumors in nude mice[2].

Animal Model:Pharmacokinetic properties of OSU-T315[1]
Dosage:50 mg/kg, daily for 4 weeks; 25 mg/kg, once daily for 2 weeks
Administration:Oral; Intraperitoneal injection (i.p.)
Result:Reduced white blood cell count and prolonged the survival of mice.
Animal Model:PC-3 tumor xenograft mice model[2]
Dosage:25, 50 mg/kg; daily; 35 days
Administration:Oral
Result:Significantly inhibited tumor growth (25 and 50 mg/kg groups inhibited 48% and 62% respectively).
Showed that the phosphorylation of Ser-473-Akt was dose-dependently inhibited, while the phosphorylation of Thr-308-Akt was not affected. At the same time, the phosphorylation levels of GSK3β and MLC and the expression levels of YB-1, HER2 and EGFR also appeared in parallel decline.

IC 50

ILK: 0.6 μM (IC50)

References

[1] Ta-Ming Liu, et al. OSU-T315: a novel targeted therapeutic that antagonizes AKT membrane localization and activation of chronic lymphocytic leukemia cells. Blood. 2015 Jan 8;125(2):284-95. DOI:10.1182/blood-2014-06-583518
[2] Su-Lin Lee, et al. Identification and characterization of a novel integrin-linked kinase inhibitor. J Med Chem. 2011 Sep 22;54(18):6364-74. DOI:10.1021/jm2007744

N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide Suppliers

China 60 United States 10 Global 70
Haoyuan Chemexpress Co., Ltd.
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021-58950125
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MedChemexpress LLC
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021-58955995
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sales@medchemexpress.cn
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Shanghai JiYi Biotechnology Co. Ltd.
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13621943973
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ShangHai Biochempartner Co.,Ltd
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Shanghai Chaolan Chemical Technology Center
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Amadis Chemical Company Limited
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1333146-24-9, N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamideRelated Search:


  • N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-1H-pyrazol-3-yl)propanamide
  • ILK-IN-1
  • BDBM50353484
  • CHEMBL1830587
  • CS-4936
  • GTPL8116
  • SCHEMBL8536228
  • OSU-T315
  • CS-2064
  • 1H-Pyrazole-3-propanamide, N-methyl-1-[4-(1-piperazinyl)phenyl]-5-[4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]-
  • ILK-IN-2 (CPD 22: OSU-T315 analog)
  • N-methyl-3-(1-(4-(piperazin-1-yl)phenyl)-5-(4-(trifluorometh
  • Integrin,inhibit,ILK IN 2,ILKIN2,Inhibitor
  • OSU-T315 analog
  • ILK-IN-2, 10 mM in DMSO
  • OSU-T315 (OSU-T 315)
  • 1333146-24-9
  • C30H30F3N5O