Tert-Butyl(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexylcarbamate oxalic acid

Product Name: Tert-Butyl(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexylcarbamate oxalic acid
CAS No.: 1353893-22-7
Chemical Name: Tert-Butyl(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexylcarbamate oxalic acid
Synonyms: Edoxaban Impurity 1(Oxalate Monohydrate);Tert-Butyl(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cycl...;5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexylcarbamate oxalic acid;Tert-Butyl(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexylcarbamate oxalic;Tert-butyl (1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexylcarbamate oxalate hydrate;tert-butyl N-[(1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl]carbamate oxalate hydrate;ert-butyl{(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl}carbamatemonooxalatemonohydrate;1353893-22-7 Tert-Butyl(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexylcarbamate oxalic acid;tert-Butyl ((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate oxalate hydrate [Commercial;tert-butyl {(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl}carbamate monooxalate monohydrate
CBNumber: CB22743479
Molecular Formula: C16H29N3O7
Formula Weight: 375.42
MOL File: 1353893-22-7.mol

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Tert-Butyl(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexylcarbamate oxalic acid Property

storage temp.: Inert atmosphere,Room Temperature
solubility: Methanol (Slightly), Water (Slightly)
form: Solid
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B810488
Product name: tert-Butyl((1R,2S,5S)-2-Amino-5-(dimethylcarbamoyl)cyclohexyl)carbamateOxalateHydrate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

Ambeed

Product number: A162610
Product name: tert-Butyl((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamateoxalatehydrate
Purity: 97%
Packaging: 5g
Price: $55
Updated: 2021/12/16

Ambeed

Product number: A162610
Product name: tert-Butyl((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamateoxalatehydrate
Purity: 97%
Packaging: 25g
Price: $173
Updated: 2021/12/16

Chemenu

Product number: CM203965
Product name: tert-butyl((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamateoxalatehydrate
Purity: 97%
Packaging: 5g
Price: $281
Updated: 2021/12/16

Crysdot

Product number: CD13024094
Product name: tert-Butyl((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamateoxalatehydrate
Purity: 97%
Packaging: 5g
Price: $297
Updated: 2021/12/16

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Tert-Butyl(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexylcarbamate oxalic acid Chemical Properties,Usage,Production

Uses

Tert-Butyl(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexylcarbamate oxalic acid is used as a pharmaceutical intermediate.

Synthesis

365998-36-3

144-62-7

1353893-22-7

General synthesis of tert-butyl ((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate oxalate hydrate of ((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate from ((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate as raw materials (45.61g, 0.16mol) and oxalic acid (18.87g, 0.21mol) The procedure was as follows: acetonitrile (595 ml) and water (43 ml) were added to tert-butyl ((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate, and the mixture was heated with stirring until the internal temperature was maintained at 50-70 °C. A pre-prepared solution consisting of anhydrous oxalic acid and acetonitrile (255 ml) was added dropwise to the solution over a period of 1 hour while maintaining the internal temperature at 50-70 °C. After completion of the dropwise addition, the reaction mixture was continued to be stirred at 50-70 °C for 5 hours and subsequently cooled to an internal temperature of 20-40 °C. The precipitated crystals were collected by filtration, washed with acetonitrile and dried to give monohydrate crystals of the target compound (59.14 g, 94.1% yield). The powder X-ray diffraction pattern of the resulting monohydrate crystals was consistent with formula (1b), and the results of their thermal analysis were consistent with those of the Type 2 monohydrate crystals in Example 2, as shown in FIGS. 4 and 8.

References

[1] Patent: EP2589590, 2013, A1. Location in patent: Paragraph 0163-0166

Tert-Butyl(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexylcarbamate oxalic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Tert-Butyl(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexylcarbamate oxalic acid Suppliers

China 92 India 1 United States 4 Global 97

Jiangsu Vcare PharmaTech Co., Ltd.

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View Lastest Price from Tert-Butyl(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexylcarbamate oxalic acid manufacturers

Anhuyan (Hainan) Biotechnology Co., LTD

Product: Tert-Butyl(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexylcarbamate oxalic acid 1353893-22-7
Price: US $0.00-0.00/G
Min. Order: 0.1G
Purity: 99%
Supply Ability: 2000000T
Release date: 2025-06-16

Anhui Ruihan Technology Co., Ltd

Product: Tert-Butyl(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexylcarbamate oxalic acid 1353893-22-7
Price: US $30.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 tons
Release date: 2023-09-08

Career Henan Chemical Co

Product: Tert-Butyl(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexylcarbamate oxalic acid 1353893-22-7
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 100kg
Release date: 2018-12-20

1353893-22-7, Tert-Butyl(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexylcarbamate oxalic acidRelated Search:

Edoxaban tosylate monohydrate Edoxaban (TsOH salt) EthanediaMide, N1-(5-chloro-2-pyridinyl)-N2-[(1R,2S,4S)-4-[(diMethylaMino)carbonyl]-2-[[(4,5,6,7-tetrahydro-5-Methylthiazolo[5,4-c]pyridin-2-yl)carbonyl]aMino]cyclohexyl]- 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride tert-Butyl [(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl]carbamate oxalate Ethyl 2-((5-chloropyridin-2-yl)amino)-2-oxoacetate hydrochloride tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate

Tert-butyl (1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexylcarbamate oxalate hydrate

Tert-Butyl(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexylcarbamate oxalic

tert-butyl {(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl}carbamate monooxalate monohydrate

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Tert-Butyl(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cycl...

1353893-22-7 Tert-Butyl(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexylcarbamate oxalic acid

tert-butyl N-[(1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl]carbamate oxalate hydrate

Carbamic acid, N-[(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl]-, 1,1-dimethylethyl ester, ethanedioate, hydrate (1:1:1)

ert-butyl{(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl}carbamatemonooxalatemonohydrate

(1R, 2S, 5S) -1-amino-4- (dimethylaminocarbonyl) - cyclohexyl-2-aminoformate tert butyl oxalate monohydrate, intermediate of Yidusaban

tert-Butyl ((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)carbamate oxalate hydrate [Commercial

Edoxaban Impurity 1(Oxalate Monohydrate)

1353893-22-7

C16H31N3O8

C14H27N3O3C2H2O4H2O