DIETHYL 2-FLUORO-2-METHYL-MALONATE
- Product Name
- DIETHYL 2-FLUORO-2-METHYL-MALONATE
- CAS No.
- 16519-02-1
- Chemical Name
- DIETHYL 2-FLUORO-2-METHYL-MALONATE
- Synonyms
- 131916;DIETHYL 2-FLUORO-2-METHYL-MALONATE;diethyl 2-fluoro-2-methylpropanedioate;Propanedioic acid,2-fluoro-2-methyl-, 1,3-diethyl ester
- CBNumber
- CB2274546
- Molecular Formula
- C8H13FO4
- Formula Weight
- 192.18
- MOL File
- 16519-02-1.mol
DIETHYL 2-FLUORO-2-METHYL-MALONATE Property
- Boiling point:
- 74-75°C 7mm
- Density
- 1?+-.0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- Appearance
- Colorless to light yellow Liquid
Safety
- Risk Statements
- 34-36/37/38
- Safety Statements
- 26-36/37/39
- RIDADR
- 1760
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
P321Specific treatment (see … on this label).
P363Wash contaminated clothing before reuse.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 128263
- Product name
- Diethyl2-fluoro-2-methylmalonate
- Purity
- 98%
- Packaging
- 1g
- Price
- $451
- Updated
- 2021/12/16
- Product number
- 5302AD
- Product name
- Diethyl2-fluoro-2-methylmalonate
- Packaging
- 10g
- Price
- $938
- Updated
- 2021/12/16
- Product number
- HCH0314459
- Product name
- DIETHYL-2-FLUORO-2-METHYL-MALONATE
- Purity
- 98.00%
- Packaging
- 10G
- Price
- $1891.89
- Updated
- 2021/12/16
- Product number
- A739666
- Product name
- Diethyl2-fluoro-2-methylmalonate
- Purity
- 95+%
- Packaging
- 25g
- Price
- $1285
- Updated
- 2021/12/16
- Product number
- CD13021068
- Product name
- Diethyl2-fluoro-2-methylmalonate
- Purity
- 95+%
- Packaging
- 10g
- Price
- $653
- Updated
- 2021/12/16
DIETHYL 2-FLUORO-2-METHYL-MALONATE Chemical Properties,Usage,Production
Synthesis Reference(s)
Journal of the American Chemical Society, 109, p. 7194, 1987 DOI: 10.1021/ja00257a051
Synthesis
609-08-5
16519-02-1
In a test tube fitted with a stir bar, N-fluorobis(methylsulfonyl)imide (38.2 mg, 0.2 mmol) and 1,2-dichloroethane (1.0 mL) were added and stirred at room temperature until completely dissolved. Subsequently, diethyl 2-methylmalonate (17.4 mg, 0.1 mmol) and tetraisopropoxy prototitanate (0.016 mL, 0.05 mmol) were added to this solution and the reaction was carried out for 12 hours at room temperature. After completion of the reaction, water was added, extracted with dichloromethane (3 times), the organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated to give the crude product. The crude product was analyzed by 19F-NMR and the yield of the target product diethyl 2-fluoro-2-methylmalonate was quantified using hexafluorobenzene as an internal standard. Finally, the product was purified by silica gel column chromatography (eluent: ethyl acetate/hexane = 10/90, v/v) to afford the purified diethyl 2-fluoro-2-methylmalonate (7) as a colorless and transparent liquid (18.7 mg, 0.097 mmol, 97% yield).
References
[1] Patent: JP2016/23178, 2016, A. Location in patent: Paragraph 0031-0033
[2] Green Chemistry, 2016, vol. 18, # 7, p. 1864 - 1868
[3] Patent: WO2017/49069, 2017, A1. Location in patent: Paragraph 00160
[4] Journal of the American Chemical Society, 1984, vol. 106, # 2, p. 452 - 454
[5] Canadian Journal of Chemistry, 1965, vol. 43, p. 1700 - 1713
DIETHYL 2-FLUORO-2-METHYL-MALONATE Preparation Products And Raw materials
Raw materials
Preparation Products
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