ChemicalBook > CAS DataBase List > AC-262536

AC-262536

Product Name
AC-262536
CAS No.
870888-46-3
Chemical Name
AC-262536
Synonyms
AC262;AC-262,356;ACP-262;Accadine;AC-262536;AC-262536;AC262;AC-262536 powder;4-(3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl)naphthalene-1-;1-Naphthalenecarbonitrile,4-[(3-endo)-3-hydroxy-8-azabicyclo...;4-(3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl)naphthalene-1-carbonitrile
CBNumber
CB22750956
Molecular Formula
C18H18N2O
Formula Weight
278.36
MOL File
870888-46-3.mol
More
Less

AC-262536 Property

Melting point:
158-162°C
Boiling point:
526.0±45.0 °C(Predicted)
Density 
1.28±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: Soluble
pka
14.73±0.20(Predicted)
InChI
InChI=1/C18H18N2O/c19-11-12-5-8-18(17-4-2-1-3-16(12)17)20-13-6-7-14(20)10-15(21)9-13/h1-5,8,13-15,21H,6-7,9-10H2/t13-,14+,15+
InChIKey
ATKWLNSCJYLXPF-FICVDOATNA-N
SMILES
O[C@H]1C[C@H]2CC[C@H](N2C2=CC=C(C#N)C3C=CC=CC2=3)C1 |&1:1,3,6,r|
More
Less

Safety

WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3278
Product name
AC-262536
Purity
≥95% (HPLC)
Packaging
10MG
Price
$87
Updated
2024/03/01
Sigma-Aldrich
Product number
SML3278
Product name
AC-262536
Purity
≥95% (HPLC)
Packaging
50MG
Price
$350
Updated
2024/03/01
DC Chemicals
Product number
DC53055
Product name
AC-262536
Packaging
1g
Price
$1800
Updated
2021/12/16
More
Less

AC-262536 Chemical Properties,Usage,Production

Uses

AC-262536 is a hydrocarbon organic matter and can be used as pharmaceutical intermediates.

General Description

AC-262536 is a selective nonsteroidal androgen receptor modulator (SARM) with beneficial anabolic effects. AC-262536 has potent agonist activity against androgen receptors with affinity in the low nanomolar range (1-10 nM). It is another novel drug put forth by Acadia, just like ACP-105. It is a SARM by design, as it selectively binds to the androgen receptor, just like all the other SARMs. AC-262536 came into light in 2007 and even though 13 years have passed, little research has been done on this compound.

Biological Activity

AC-262536 exhibits potency at AR similar to that observed for the natural ligand testosterone, 13 nM vs. 2 nM, respectively. Interestingly, AC-262536 behaved as a partial agonist (% Eff 67 ± 9) relative to testosterone. In reporter gene assays, AC-262536 modulated the transcriptional activity of a natural target gene in an AR-dependent manner with low nanomolar potency (2 nM). It displayed partial agonism properties (% Eff 72 ± 9) relative to testosterone. Further, AC-262536 physically interacted with AR with an affinity of 5 nM. Profiling at other nuclear receptors revealed that AC-262536 is extremely selective for AR, having no significant affinity for the other 47 human nuclear receptors, including the steroid receptors estrogen ERs, glucocorticoid GR, mineraloid MR, and progesterone PR, at doses as high as 10M (data not shown)[1].

Side effects

Testosterone Suppression: AC-262536 will suppress your natural testosterone levels. Compared to other SARMs, this suppression of testosterone is rather mild and similar to that of Ostarine and Andarine. Testosterone suppression can manifest in the following symptoms: Lethargy, Lack of motivation, Decreased libido, Weaker erections, Testicular pain, and Testicular atrophy. AC-262536 will cause dyslipidemia. Your HDL will decrease, and your LDL will increase during an AC-262 cycle. The extent of this side effect can be compared to that of similarly strong SARMs. The following side effects can happen to anyone who alters their endocrine balance, regardless of whether they’re taking AC-262 or something else: Gynecomastia: men who had pubertal gyno are at risk of redeveloping it if they take AC-262536; Hair shedding (temporary and completely reversible); Insomnia.

References

[1] Fabrice Piu . “Pharmacological characterization of AC-262536, a novel selective androgen receptor modulator.” Journal of Steroid Biochemistry and Molecular Biology 109 1 (2008): Pages 129-137.

AC-262536 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

AC-262536 Suppliers

Jinan Junnuo Trading Co., LTD
Tel
13345898948
Email
1301260554@qq.com
Country
China
ProdList
105
Advantage
58
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883 15367835770
Fax
0731-82251112
Email
viola@huatengsci.com
Country
China
ProdList
5877
Advantage
58
Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Country
China
ProdList
51471
Advantage
80
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9708
Advantage
58
Wuhan Wsem Biological Co., Ltd.
Tel
027-83778876 13667159345
Fax
027-83778876
Email
13667159345@163.com
Country
China
ProdList
1967
Advantage
55
Aikon International Limited
Tel
025-58859352 18068836627
Fax
02557626880
Email
sales01@aikonchem.com
Country
China
ProdList
15085
Advantage
58
Henan Alfachem Co.,Ltd.
Tel
0371-0371-55051623 18137891487
Fax
QQ:2853979817
Email
2853979817@qq.com
Country
China
ProdList
9967
Advantage
58
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-0371-63315541 13323832564
Fax
QQ:3001332135
Email
3001332135@qq.com
Country
China
ProdList
10002
Advantage
58
Guangzhou Belka Biological Technology Co., Ltd.
Tel
+86-18665676617
Fax
18665676617
Country
China
ProdList
958
Advantage
58
ANHUI WITOP BIOTECH CO., LTD
Tel
+8615255079626
Email
eric@witopchemical.com
Country
China
ProdList
23556
Advantage
58
More
Less

View Lastest Price from AC-262536 manufacturers

Wuhan Cell Pharmaceutical Co., Ltd
Product
AC-262536 870888-46-3
Price
US $9.90/g
Min. Order
1g
Purity
99%
Supply Ability
100kg
Release date
2023-03-30
Dorne Chemical Technology co. LTD
Product
AC-262536 870888-46-3
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
100kg
Release date
2024-03-26
Shanghai Affida new material science and technology center
Product
AC-262536 870888-46-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99
Supply Ability
10 tons
Release date
2024-04-26

870888-46-3, AC-262536Related Search:


  • AC-262536
  • AC-262,356
  • 4-(3-endo-Hydroxy-8-azabicyclo[3.2.1]oct-8-yl)naphthalene-1-carbonitrile
  • 4-[(3-endo)-3-Hydroxy-8-azabicyclo[3.2.1]oct-8-yl]naphthalene-1-carbonitrile
  • AC262
  • AC-262536;AC262
  • AC-262536 powder
  • 4-(3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl)naphthalene-1-carbonitrile
  • 1-Naphthalenecarbonitrile, 4-[(3-endo)-3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl]-
  • 1-Naphthalenecarbonitrile,4-[(3-endo)-3-hydroxy-8-azabicyclo...
  • Accadine
  • 4-(3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl)naphthalene-1-
  • ACP-262
  • SARM,modulator,AC-262536,Inhibitor,AC 262536,receptor,androgen,anabolic,Androgen Receptor,inhibit,non-steroidal
  • 4-[(3-endo)-3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl]-1-naphthalenecarbonitrile
  • 870888-46-3
  • 870888-46-3
  • SARMS