Acid Blue 90

ChemicalBook > CAS DataBase List > Acid Blue 90

Product Name: Acid Blue 90
CAS No.: 6104-58-1
Chemical Name: Acid Blue 90
Synonyms: BRILLIANT BLUE;BRILLIANT BLUE G;COOMASSIE BRILLIANT BLUE G-250;G-250;COOMASSIE BRILLIANT BLUE G;CI 42655;CBB G-250;Cyanine G;Blue G 250;CI NO 42655
CBNumber: CB2275235
Molecular Formula: C47H48N3NaO7S2
Formula Weight: 854.02
MOL File: 6104-58-1.mol

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Acid Blue 90 Property

Melting point:: 100 °C
Density: 1.274[at 20℃]
vapor pressure: 0.093Pa at 20℃
Flash point:: 11 °C
storage temp.: 2-8°C
solubility: H2O: soluble1mg/mL
Colour Index: 42655
form: Solid
color: Dark blue-violet-brown
Water Solubility: Soluble in water (50 mg/ml) and ethanol (40 mg/ml).
BRN: 5230822
Stability:: Light Sensitive
InChIKey: JFNOCRSXNFZMNT-UHFFFAOYSA-M
LogP: -2.55 at 20℃
CAS DataBase Reference: 6104-58-1(CAS DataBase Reference)
EPA Substance Registry System: C.I. Acid Blue 90 (6104-58-1)

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Safety

Risk Statements
Safety Statements
WGK Germany: 3
TSCA: Yes
HS Code: 32041200

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 27815
Product name: Brilliant Blue G
Purity: 250, for microscopy
Packaging: 25g
Price: $59.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: 27815
Product name: Brilliant Blue G
Purity: 250, for microscopy
Packaging: 100g
Price: $183
Updated: 2024/03/01

TCI Chemical

Product number: B1146
Product name: Brilliant Blue G
Packaging: 25g
Price: $30
Updated: 2024/03/01

TCI Chemical

Product number: B3193
Product name: Coomassie Brilliant Blue G-250 [for Electrophoresis]
Packaging: 5g
Price: $21
Updated: 2024/03/01

Alfa Aesar

Product number: 043318
Product name: Brilliant Blue G, ultrapure
Packaging: 2g
Price: $21.65
Updated: 2024/03/01

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Acid Blue 90 Chemical Properties,Usage,Production

Chemical Properties

dark blue-violet-brown crystalline powder

Uses

Brilliant Blue G is used in analytical biochemistry dye and as a P2X7 antagonist. It is also used in protein staining following gel electrophoresis. It is used to prepare the protein reagent for the determination of protein content of the collagenase enzyme isolated from fish waste. It may be employed as stain for the internal limiting membrane (ILM) for the macular hole (MH) and epiretinal membrane (ERM) surgery. It is useful for SDS gels as it readily stains proteins with minimal background color. Protein bands can be visualized during staining. It has been used in the Bradford dye-binding protein assay. A mechanism for dye binding to protein has been proposed, based on measuring Coomassie Brilliant Blue G-250 (CBBG) absorbance spectra during titration of the dye reagent in the absence of protein and its response to different polyamino acids. Brilliant Blue G has been used for determining critical micelle concentration of detergents.

Preparation

Benzaldehyde ?(1 Moore) and N-ethyl-N-benzyl-3-methylaniline?(2 Moore) condensation, And then sulfonating the product of three acids, and lead oxide, peroxide, and then the reaction with the 4-Ethoxybenzenamine, Benzaldehyde ?sulfonic acid groups on the phenyl ring is substituted anilino-ethoxy.

General Description

Brilliant Blue G (BBG) is a dye. It has been proposed as a substitute for internal limiting membrane (ILM) peeling.

Flammability and Explosibility

Not classified

Biological Activity

brilliant blue g is also a selective inhibitor of the p2x purinoceptor channel p2x7 [1].p2x receptors are membrane ion channels activated in response to the binding of extracellular atp. seven p2x subtypes have been identified. p2x receptors have been involved in in diverse patho- and physiological processes, such as the autonomic nervous system, afferent signalling, chronic pain, and in autocrine loops of endothelial and epithelial cells. the p2x7 receptor plays a prominent role in certain neurologic disorders, such as ischemia-reperfusion injury, alzheimer's disease, spinal cord injury and sensory neuropathies [2].in hek293 cells heterologously expressing human p2x7 receptors, brilliant blue g noncompetitively inhibited rat and human p2x7 receptors with ic50 values of 10 and 200 nm, respectively. the ic50 values for inhibition of the other p2x receptors ranged from 2 to >30 μm; brilliant blue g inhibited the rat and human p2x4 receptors with the ic50 values of >10 and 3.2 μm [1]. subretinal injection of bbg caused retinal cell degeneration at lower concentrations. subretinal injection of bbg (0.25 mg/ml) provided satisfactory biocompatibility [3].

Biochem/physiol Actions

P2X7 purinergic receptor antagonist.

storage

Room temperature

Properties and Applications

bright blue. Dark brown powder, slightly soluble in water, soluble in hot water (bright blue) and ethanol (bright blue). When a blood-red of sulfuric acid, a orange red after diluted. Its water solution and sodium hydroxide for purple. Used for wool and silk dyeing, also can be used for leather dyeing.

Standard	Light Fastness	Soaping		Persperation Fastness	Oxygen bleaching		Fastness to seawater
Standard	Light Fastness	Fading	Stain	Persperation Fastness	Fading	Stain	Fading	Stain
ISO	3	3	4-5	3-4	1	1	4	4
AATCC	3	3-4	3-4	4-5	1	1	4-5	4-5

References

[1] jiang l h, mackenzie a b, north r a, et al. brilliant blue g selectively blocks atp-gated rat p2x7 receptors[j]. molecular pharmacology, 2000, 58(1): 82-88.
[2] sperlágh b, vizi e s, wirkner k, et al. p2x 7 receptors in the nervous system[j]. progress in neurobiology, 2006, 78(6): 327-346.
[3] ueno a, hisatomi t, enaida h, et al. biocompatibility of brilliant blue g in a rat model of subretinal injection[j]. retina, 2007, 27(4): 499-504.

Acid Blue 90 Preparation Products And Raw materials

Raw materials

N-benzyl-N-ethyl m-toluidine Phenetidine Ethylbenzyltoluidine Trisulfonic acid Benzaldehyde

Preparation Products

ACID BLUE 9 ALUMINUM LAKE Erioglaucine disodium salt

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View Lastest Price from Acid Blue 90 manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Acid Blue 90 6104-58-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%min
Supply Ability: 10mt
Release date: 2024-08-01

AFINE CHEMICALS LIMITED

Product: BRILLIANT BLUE
Price: US $0.00/kg
Min. Order: 100kg
Purity: 100% strength
Supply Ability: 50 tons
Release date: 2023-12-12

Nanjing Sky Hope Tongyuan Biological Engineering Co., Ltd.

Product: brilliant blue
Price: US $22.00/kg
Min. Order: 1kg
Purity: 100%
Supply Ability: 100
Release date: 2022-10-13

6104-58-1, Acid Blue 90Related Search:

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