MK-8931
- Product Name
- MK-8931
- CAS No.
- 1286770-55-5
- Chemical Name
- MK-8931
- Synonyms
- CS-2556;SCH900931;SCH-900931;SCH 900931;MK-8931-009;Verubecestat;MK-8931(Verubecestat);Verubecestat (MK-8931);Verubecestat free base;MK8931;MK 8931;MK-8931
- CBNumber
- CB22756736
- Molecular Formula
- C17H17F2N5O3S
- Formula Weight
- 409.41
- MOL File
- 1286770-55-5.mol
MK-8931 Property
- Melting point:
- 160-162oC
- Density
- 1.52±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Store in freezer, under -20°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 9.92±0.70(Predicted)
- form
- Solid
- color
- White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 21115
- Product name
- Verubecestat
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $29
- Updated
- 2024/03/01
- Product number
- 21115
- Product name
- Verubecestat
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $99
- Updated
- 2024/03/01
- Product number
- 21115
- Product name
- Verubecestat
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $141
- Updated
- 2024/03/01
- Product number
- 21115
- Product name
- Verubecestat
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $246
- Updated
- 2024/03/01
- Product number
- V128850
- Product name
- Verubecestat
- Packaging
- 25mg
- Price
- $235
- Updated
- 2021/12/16
MK-8931 Chemical Properties,Usage,Production
Uses
Verubecestat is used in a β-site amyloid precursor protein cleaving enzyme I inhibitor of treatment of alzheimer’s disease.
Biological Activity
ki: 2.2 and 3.4 nm for human and mouse bace1, respectivelyverubecestat (mk-8931) is a bace1 inhibitor.β-amyloid (aβ) peptides are regarded to be involved in the etiology of ad. bace1 is required for the aβ production, and bace1 inhibition is therefore an promising target for the ad treatment.
in vitro
verubecestat has been identified as a potent inhibitor of both human and mouse bace1 and verubecestat could also inhibit the production of ab40, ab42, and sappb in human cells with similar potency. verubecestat was also found to be a potent inhibitor of purified human bace2. moreover, verubecestat was essentially inactive with over 45,000-fold selectivity in the purified human aspartyl proteases cathepsin d, cathepsin e, and pepsin and had a very weak inhibitor of purified human renin with 15,000-fold selectivity. in addition, verubecestat was also found to have minimal or no activity against various tested receptors, ion channels, transporters, as well as enzymes [1].
in vivo
verubecestat could reduce plasma, cerebrospinal fluid, and brain concentrations of aβ40, aβ42, and sappβ after acute and chronic administration to both rats and monkeys. moreover, the chronic treatment of rats and monkeys with verubecestat at exposures >40-fold higher than those tested in
storage
Store at -20°C
References
[1] kennedy me et al. the bace1 inhibitor verubecestat (mk-8931) reduces cns β-amyloid in animal models and in alzheimer's disease patients. sci transl med.2016 nov 2;8(363):363ra150.
MK-8931 Preparation Products And Raw materials
Raw materials
Preparation Products
MK-8931 Suppliers
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View Lastest Price from MK-8931 manufacturers
- Product
- MK-8931 1286770-55-5
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200KG
- Release date
- 2019-07-01