AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE

Product Name: AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE
CAS No.: 55779-32-3
Chemical Name: AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE
Synonyms: SHX;dl-serine hydroxamate;Propanamide, 2-amino-N,3-dihydroxy-;DL-SERINE HYDROXAMATE, SERYL-TRNA SY;(Z)-2-aMino-N,3-dihydroxypropaniMidic acid;AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE;rac-(R*)-2-Amino-3-hydroxypropanehydroxamic acid;DL-Serine hydroxaMate seryl-tRNA synthetase inhibitor
CBNumber: CB2281528
Molecular Formula: C3H8N2O3
Formula Weight: 120.11
MOL File: 55779-32-3.mol

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AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE Property

storage temp.: -20°C
form: Solid
color: White to off-white

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S4503
Product name: DL-Serine hydroxamate
Purity: seryl-tRNA synthetase inhibitor
Packaging: 250mg
Price: $512
Updated: 2024/03/01

Sigma-Aldrich

Product number: S4503
Product name: DL-Serine hydroxamate
Purity: seryl-tRNA synthetase inhibitor
Packaging: 1g
Price: $1760
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: AAA0006058
Product name: DL-SERINE HYDROXAMATE
Purity: 95.00%
Packaging: 5MG
Price: $503.36
Updated: 2021/12/16

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AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE Chemical Properties,Usage,Production

Uses

Serine has been used as an inhibitor of seryl-tRNA synthetase. DL-Serine hydroxamate is used to induce metabolic synthesis of guanosine 3′-diphosphate 5′-diphosphate (ppGpp) in E. coli by amino acid starvation. It is also used to synchronize cell cycle in E. coli cultures by inhibition of tRNA charging.

Definition

ChEBI: Serine hydroxamate is a hydroxamic acid obtained by formal condensation of the carboxy group of serine with the amino group of hydroxylamine. It has a role as an EC 6.1.1.11 (serine--tRNA ligase) inhibitor. It is a hydroxamic acid and a serine derivative.

Biochem/physiol Actions

Serine is involved in the one-carbon unit metabolism. It is associated with the biosynthesis of cysteine, ceramide, phosphatidylserine, purine and pyrimidine. In bacteria, it participates in tryptophan synthesis. Gluconeogenesis, one of the important biochemical processes, involves serine, particularly in ruminants. Protein phosphorylation is one such event that utilizes serine. Glycine, a metabolic product of serine, serves as an antioxidant and a neurotransmitter. D-serine is known to activate the N-methyl-D-aspartate (NMDA) receptors of the brain. Serine hydroxamate, a structural analogue of serine prevents seryl-tRNA (transfer ribonucleic acid) charging and thereby decreases phospholipid and nucleic acid synthesis in Escherichia coli.

AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE Preparation Products And Raw materials

Raw materials

Preparation Products

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AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE Suppliers

China 13 India 1 Japan 1 Switzerland 1 United States 2 Global 18

Syntechem Co.,Ltd

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55779-32-3, AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATERelated Search:

O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI AMINO ACID HYDROXAMATES DL-THREONINE HYDROXAMATE 2-ACETAMIDO-2-DEOXY-D-GLUCONHYDROXIMO-1,5-LACTONE AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE AMINO ACID HYDROXAMATES GLYCINE HYDROXAMATE

AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE

rac-(R*)-2-Amino-3-hydroxypropanehydroxamic acid

DL-Serine hydroxaMate seryl-tRNA synthetase inhibitor

(Z)-2-aMino-N,3-dihydroxypropaniMidic acid

SHX

DL-SERINE HYDROXAMATE, SERYL-TRNA SY

dl-serine hydroxamate

Propanamide, 2-amino-N,3-dihydroxy-

55779-32-3

I - Z

BioChemical

Amino Acids and Peptides

Biochemicals and Reagents

Modified Amino Acids

Isoleucine [Ile, I]

Amino Acids

I - Z

Modified Amino Acids