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AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE

Product Name
AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE
CAS No.
55779-32-3
Chemical Name
AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE
Synonyms
SHX;dl-serine hydroxamate;Propanamide, 2-amino-N,3-dihydroxy-;DL-SERINE HYDROXAMATE, SERYL-TRNA SY;(Z)-2-aMino-N,3-dihydroxypropaniMidic acid;AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE;rac-(R*)-2-Amino-3-hydroxypropanehydroxamic acid;DL-Serine hydroxaMate seryl-tRNA synthetase inhibitor
CBNumber
CB2281528
Molecular Formula
C3H8N2O3
Formula Weight
120.11
MOL File
55779-32-3.mol
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AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE Property

storage temp. 
-20°C
form 
Solid
color 
White to off-white
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S4503
Product name
DL-Serine hydroxamate
Purity
seryl-tRNA synthetase inhibitor
Packaging
250mg
Price
$512
Updated
2024/03/01
Sigma-Aldrich
Product number
S4503
Product name
DL-Serine hydroxamate
Purity
seryl-tRNA synthetase inhibitor
Packaging
1g
Price
$1760
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
AAA0006058
Product name
DL-SERINE HYDROXAMATE
Purity
95.00%
Packaging
5MG
Price
$503.36
Updated
2021/12/16
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AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE Chemical Properties,Usage,Production

Uses

Serine has been used as an inhibitor of seryl-tRNA synthetase. DL-Serine hydroxamate is used to induce metabolic synthesis of guanosine 3′-diphosphate 5′-diphosphate (ppGpp) in E. coli by amino acid starvation. It is also used to synchronize cell cycle in E. coli cultures by inhibition of tRNA charging.

Definition

ChEBI: Serine hydroxamate is a hydroxamic acid obtained by formal condensation of the carboxy group of serine with the amino group of hydroxylamine. It has a role as an EC 6.1.1.11 (serine--tRNA ligase) inhibitor. It is a hydroxamic acid and a serine derivative.

Biochem/physiol Actions

Serine is involved in the one-carbon unit metabolism. It is associated with the biosynthesis of cysteine, ceramide, phosphatidylserine, purine and pyrimidine. In bacteria, it participates in tryptophan synthesis. Gluconeogenesis, one of the important biochemical processes, involves serine, particularly in ruminants. Protein phosphorylation is one such event that utilizes serine. Glycine, a metabolic product of serine, serves as an antioxidant and a neurotransmitter. D-serine is known to activate the N-methyl-D-aspartate (NMDA) receptors of the brain. Serine hydroxamate, a structural analogue of serine prevents seryl-tRNA (transfer ribonucleic acid) charging and thereby decreases phospholipid and nucleic acid synthesis in Escherichia coli.

AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE Preparation Products And Raw materials

Raw materials

Preparation Products

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AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE Suppliers

Hamari Chemicals, Ltd.
Tel
--
Fax
--
Email
ask@hamari.co.jp
Country
Japan
ProdList
112
Advantage
69

55779-32-3, AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATERelated Search:


  • AMINO ACID HYDROXAMATES DL-SERINE HYDROXAMATE
  • rac-(R*)-2-Amino-3-hydroxypropanehydroxamic acid
  • DL-Serine hydroxaMate seryl-tRNA synthetase inhibitor
  • (Z)-2-aMino-N,3-dihydroxypropaniMidic acid
  • SHX
  • DL-SERINE HYDROXAMATE, SERYL-TRNA SY
  • dl-serine hydroxamate
  • Propanamide, 2-amino-N,3-dihydroxy-
  • 55779-32-3
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