ChemicalBook > CAS DataBase List > (-)-Corey Lactone Benzoate

(-)-Corey Lactone Benzoate

Product Name
(-)-Corey Lactone Benzoate
CAS No.
39746-00-4
Chemical Name
(-)-Corey Lactone Benzoate
Synonyms
(3aR,4S,5R,6aS)-4-(hydroxyMethyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl benzoate;BCOD;PGX 4;COREY'S LACTONE;lactone benzoate;(-) Benzoyl lactone;Iloprost Impurity 16;Benzoic acid lactone;BENZOYL COREY LACTONE;Travoprost Impurity 31
CBNumber
CB2282525
Molecular Formula
C15H16O5
Formula Weight
276.28
MOL File
39746-00-4.mol
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(-)-Corey Lactone Benzoate Property

Melting point:
116-120 °C
alpha 
-80 º (c=0.8, CHCl3 25 ºC)
Boiling point:
379.19°C (rough estimate)
Density 
1.2379 (rough estimate)
refractive index 
1.5000 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
14.79±0.10(Predicted)
color 
White to Pale Yellow
InChI
InChI=1S/C15H16O5/c16-8-11-10-6-14(17)19-12(10)7-13(11)20-15(18)9-4-2-1-3-5-9/h1-5,10-13,16H,6-8H2/t10-,11-,12+,13-/m1/s1
InChIKey
OBRRYUZUDKVCOO-FVCCEPFGSA-N
SMILES
O1C(=O)C[C@]2([H])[C@@H](CO)[C@H](OC(=O)C3=CC=CC=C3)C[C@]12[H]
CAS DataBase Reference
39746-00-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36/37/39-26
HS Code 
29321900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C2605
Product name
(-)-Corey Lactone Benzoate
Purity
>98.0%(HPLC)
Packaging
1g
Price
$291
Updated
2025/07/31
TCI Chemical
Product number
C2605
Product name
(-)-Corey Lactone Benzoate
Purity
>98.0%(HPLC)
Packaging
200mg
Price
$90
Updated
2025/07/31
TRC
Product number
C694990
Product name
(-)-Corey Lactone Benzoate
Packaging
1g
Price
$95
Updated
2021/12/16
TRC
Product number
C694990
Product name
(-)-Corey Lactone Benzoate
Packaging
25g
Price
$910
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK195857
Product name
(-)-Corey Lactone Benzoate
Purity
97%
Packaging
100mg
Price
$45
Updated
2021/12/16
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(-)-Corey Lactone Benzoate Chemical Properties,Usage,Production

Chemical Properties

Colorless crystalline powder

Uses

(-)-Corey Lactone Benzoate is a corey lactone derivative used in the preparation prostaglandin analogues for use as vasolidator as well as EP4 receptor agonists.

Synthesis

39746-01-5

39746-00-4

A 1:1 methanol:methylene chloride solution (40 mL) of (3aR,4R,5R,6aS)-5-(benzoyloxy)hexahydro-2H-cyclopenta[b]furan-2-one-4-carbaldehyde (1) (purchased from Cayman Chemical Company, Ann Arbor, MI) (3.5 g, 12.8 mmol) in a 1:1 methanol:dichloromethane solution (40 mL). After 25 min of reaction, the reaction was quenched by careful addition of saturated aqueous citric acid solution (60 mL). The mixture was extracted with ethyl acetate (3 × 40 mL) and the organic layers were combined and washed sequentially with water (2 × 80 mL) and saturated saline (2 × 80 mL). The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the target compound 2 (2.43 g, 69% yield).

References

[1] Patent: US6353000, 2002, B1. Location in patent: Page column 10
[2] Journal of Pharmacology and Experimental Therapeutics, 1999, vol. 290, # 3, p. 1278 - 1284
[3] Patent: US6353014, 2002, B1. Location in patent: Page column 18

(-)-Corey Lactone Benzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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(-)-Corey Lactone Benzoate Suppliers

Americas 1 Belgium 1 Canada 1 China 249 Czech 1 Europe 1 Germany 1 India 13 Japan 2 Switzerland 1 United Kingdom 3 United States 19 Global 293
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3572
Advantage
66
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View Lastest Price from (-)-Corey Lactone Benzoate manufacturers

HANGZHOU HAILAN CHEMICAL CO.,LTD.
Product
(-)-Corey Lactone Benzoate 39746-00-4
Price
US $0.00/g
Min. Order
1g
Purity
99%min
Supply Ability
200kgs
Release date
2025-10-22
WUHAN FORTUNA CHEMICAL CO., LTD
Product
(-)-Corey Lactone Benzoate 39746-00-4
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
99.0%min
Supply Ability
10 KGS
Release date
2021-06-08
Sinoway Industrial co., ltd.
Product
(-)-Corey Lactone Benzoate 39746-00-4
Price
US $0.00/Kg/Bag
Min. Order
2Kg/Bag
Purity
98% up
Supply Ability
20 tons
Release date
2021-07-13

39746-00-4, (-)-Corey Lactone BenzoateRelated Search:

(-)-Corey lactone diol N-(2-CARBOXYBENZOYL)-(-)-10,2-CAMPHORSULTAM 4-Aminophenol Gibberellic acid 2H-Cyclopenta[b]furan-2-one,hexahydro-5-hydroxy-4-(hydroxymethyl)- (1S,5R)-(-)-2-OXABICYCLO[3.3.0]OCT-6-EN-3-ONE 4-(T-BUTYLDI-ME-SIO-ME)HEXA-H-5-(T-H-PYR AN -2-YLOXY)-CYCLOPENTA(B)FURAN-2-ON, 97 (3aR,4S,5R,6aS)-4-(hydroxyMethyl)-5-(triethylsilyloxy)-hexahydro-cyclopentafuran-2-one 2H-Cyclopenta[b]furan-2-one, hexahydro-4-(hydroxymethyl)-5-[(tetrahydro-2H-pyran-2-yl)oxy]-, (3aR,4S,5R,6aS)- (-)-Corey Lactone Diol Trelagliptin succinate (3-TRIFLUOROMETHYLPHENOXY) ACETIC ACID ETHYL ESTER (R)-4-fluoro-2-((3-methyl-2,4-dioxo-6-(piperidin-3-ylamino)-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile Travoprost Impurity 19 TrifluoroMethyl Dechloro 2-((6-chloro-3-Methyl-2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)Methyl)-4-fluorobenzonitrile (-)-Corey aldehyde benzoate (3-TRIFLUOROMETHYL-PHENOXY)-ACETIC ACID

  • 5-(Benzoyloxy)hexahydro-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one(3aα,4α,5β,6aα)
  • (-)-5-(BENZOYLOXY)HEXAHYDRO-4-(HYDROXYME)-2H-CYCLOPENTA(B)FURAN-2-ONE, 97%
  • 5-(BENZOYLOXY) HEXAHYDRO-4-(HYDROXYMETHYL)-2H-CYCLOPENTA[B]FURAN-2-ONE
  • BENZOYL COREY LACTONE
  • (-)-COREY LACTONE BENZOATE 99%
  • (-)-COREY LACTONE BENZOATE: (3AR,4S,5R,6AS)-(-)-5-(BENZOYLOXY)-HEXAHYDRO-4(-HYDROXYMETHYL)-2H-CYCLOPENTA[B]FURAN-2-ONE
  • (-)-6-BETA-HYDROXYMETHYL-7-ALPHA-BENZOYLOXY-CIS-2-OXABICYCLO[3.3.0]OCTAN-3-ONE(COREY''S LACTONE)
  • [3aR-(3aα,4α,5β,6aα)]-5-(Benzoyloxy)hexahydro-4-(hydroxyMethyl)-2H-cyclopenta[b]furan-2-one
  • PGX 4
  • (1R)-2β-(Hydroxymethyl)-3α-(benzoyloxy)-5α-hydroxycyclopentane-1α-acetic acid 1,5-lactone
  • (1S,5R,6S,7R)-7-Benzoyloxy-6-hydroxymethyl-2-oxabicyclo[3.3.0]octan-3-one
  • (3aβ,6aβ)-4β-(Hydroxymethyl)-5α-(benzoyloxy)hexahydro-2H-cyclopenta[b]furan-2-one
  • (3aR,4S,5R,6aS)-4-(hydroxyMethyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl benzoate
  • (-) Corey Alcohol Benzoate
  • (3AR,4S,5R,6AS)-(-)-5-(BENZOYLOXY)-HEXAHYDRO-4(-HYDROXYMETHYL)-2H-CYCLOPENTA[B]FURAN-2-ONE
  • 5-(BENZOYLOXY) HEXAHYDRO-4-(HYDROXYMETHYL)-2H-CYCLOPENTA[B]FURAN-2-ONE (3AA,4A,5BETA,6AA)
  • (-)-6-BETA-HYDROXYMETHYL-7-ALPHA-BENZOYLOXY-CIS-2-OXABICYCLO[3.3.0]OCTAN-3-ONE
  • (-)-5-(benzoyloxy)hexahydro-4-(hydroxyme)-2H-cycl
  • [3aR-(3aalpha,4alpha,5beta,6aalpha)]-hexahydro-4-(hydroxymethyl)-2-oxo-2H-cyclopenta[b]furan-5-yl benzoate
  • (-)-Corey Lactone Benzoate Basic information
  • 2H-Cyclopenta[b]furan-2-one, 5-(benzoyloxy)hexahydro-4-(hydroxymethyl)-, (3aR,4S,5R,6aS)-
  • BCOD
  • COREY'S LACTONE
  • benzoic acid [4-(hydroxymethyl)-2-oxo-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-5-yl] ester
  • lactone benzoate
  • (-)-Corey Lactone Benzoate in stock Factory
  • [(3aR,4S,5R,6aS)-4-(hydroxymethyl)-2-oxo-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-5-yl] benzoate
  • (-)-Corey Lactone Benzoate &gt
  • Travoprost Impurity 31
  • Travoprost Impurity 54
  • (-)corey lactone benzoate
  • (-)-Corey Lactone Benzoate USP/EP/BP
  • (-)-Corey lactone benzoate(For export only)
  • Tafluprost Impurity 11 (Corey lactone benzoate)
  • (-)-Corey Lactone Benzoate
  • BCOD (-)-Corey Lactone Benzoate 39746-00-4
  • Iloprost Impurity 16
  • (-) - Benzoic acid corylilide
  • (-) Benzoyl lactone
  • Benzoic acid lactone
  • 39746-00-4
  • 39746-60-4
  • Latanoprost
  • Prostaglandins