(-)-Corey Lactone Benzoate

Product Name: (-)-Corey Lactone Benzoate
CAS No.: 39746-00-4
Chemical Name: (-)-Corey Lactone Benzoate
Synonyms: (3aR,4S,5R,6aS)-4-(hydroxyMethyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl benzoate;BCOD;PGX 4;COREY'S LACTONE;lactone benzoate;(-) Benzoyl lactone;Iloprost Impurity 16;Benzoic acid lactone;BENZOYL COREY LACTONE;Travoprost Impurity 31
CBNumber: CB2282525
Molecular Formula: C15H16O5
Formula Weight: 276.28
MOL File: 39746-00-4.mol

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(-)-Corey Lactone Benzoate Property

Melting point:: 116-120 °C
alpha: -80 º (c=0.8, CHCl3 25 ºC)
Boiling point:: 379.19°C (rough estimate)
Density: 1.2379 (rough estimate)
refractive index: 1.5000 (estimate)
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
pka: 14.79±0.10(Predicted)
color: White to Pale Yellow
InChI: InChI=1S/C15H16O5/c16-8-11-10-6-14(17)19-12(10)7-13(11)20-15(18)9-4-2-1-3-5-9/h1-5,10-13,16H,6-8H2/t10-,11-,12+,13-/m1/s1
InChIKey: OBRRYUZUDKVCOO-FVCCEPFGSA-N
SMILES: O1C(=O)C[C@]2([H])[C@@H](CO)[C@H](OC(=O)C3=CC=CC=C3)C[C@]12[H]
CAS DataBase Reference: 39746-00-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22
Safety Statements: 36/37/39-26
HS Code: 29321900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C2605
Product name: (-)-Corey Lactone Benzoate
Purity: >98.0%(HPLC)
Packaging: 1g
Price: $291
Updated: 2025/07/31

TCI Chemical

Product number: C2605
Product name: (-)-Corey Lactone Benzoate
Purity: >98.0%(HPLC)
Packaging: 200mg
Price: $90
Updated: 2025/07/31

TRC

Product number: C694990
Product name: (-)-Corey Lactone Benzoate
Packaging: 1g
Price: $95
Updated: 2021/12/16

TRC

Product number: C694990
Product name: (-)-Corey Lactone Benzoate
Packaging: 25g
Price: $910
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0066302
Product name: (-)-COREY LACTONE BENZOATE
Purity: 95.00%
Packaging: 1G
Price: $1963.5
Updated: 2021/12/16

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(-)-Corey Lactone Benzoate Chemical Properties,Usage,Production

Chemical Properties

Colorless crystalline powder

Uses

(-)-Corey Lactone Benzoate is a corey lactone derivative used in the preparation prostaglandin analogues for use as vasolidator as well as EP4 receptor agonists.

Synthesis

39746-01-5

39746-00-4

A 1:1 methanol:methylene chloride solution (40 mL) of (3aR,4R,5R,6aS)-5-(benzoyloxy)hexahydro-2H-cyclopenta[b]furan-2-one-4-carbaldehyde (1) (purchased from Cayman Chemical Company, Ann Arbor, MI) (3.5 g, 12.8 mmol) in a 1:1 methanol:dichloromethane solution (40 mL). After 25 min of reaction, the reaction was quenched by careful addition of saturated aqueous citric acid solution (60 mL). The mixture was extracted with ethyl acetate (3 × 40 mL) and the organic layers were combined and washed sequentially with water (2 × 80 mL) and saturated saline (2 × 80 mL). The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the target compound 2 (2.43 g, 69% yield).

References

[1] Patent: US6353000, 2002, B1. Location in patent: Page column 10
[2] Journal of Pharmacology and Experimental Therapeutics, 1999, vol. 290, # 3, p. 1278 - 1284
[3] Patent: US6353014, 2002, B1. Location in patent: Page column 18

(-)-Corey Lactone Benzoate Preparation Products And Raw materials

Raw materials

Preparation Products

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(-)-Corey Lactone Benzoate Suppliers

Americas 1 Belgium 1 Canada 1 China 249 Czech 1 Europe 1 Germany 1 India 13 Japan 2 Switzerland 1 United Kingdom 3 United States 19 Global 293

TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
ProdList: 28387
Advantage: 80

Kanto Chemical Co., Inc.

Tel: --
Fax: --
Email: reag-info@gms.kanto.co.jp
Country: Japan
ProdList: 6756
Advantage: 74

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View Lastest Price from (-)-Corey Lactone Benzoate manufacturers

HANGZHOU HAILAN CHEMICAL CO.,LTD.

Product: (-)-Corey Lactone Benzoate 39746-00-4
Price: US $0.00/g
Min. Order: 1g
Purity: 99%min
Supply Ability: 200kgs
Release date: 2025-10-22

WUHAN FORTUNA CHEMICAL CO., LTD

Product: (-)-Corey Lactone Benzoate 39746-00-4
Price: US $0.00-0.00/KG
Min. Order: 1g
Purity: 99.0%min
Supply Ability: 10 KGS
Release date: 2021-06-08

Sinoway Industrial co., ltd.

Product: (-)-Corey Lactone Benzoate 39746-00-4
Price: US $0.00/Kg/Bag
Min. Order: 2Kg/Bag
Purity: 98% up
Supply Ability: 20 tons
Release date: 2021-07-13

39746-00-4, (-)-Corey Lactone BenzoateRelated Search:

(-)-Corey lactone diol N-(2-CARBOXYBENZOYL)-(-)-10,2-CAMPHORSULTAM 4-Aminophenol Gibberellic acid 2H-Cyclopenta[b]furan-2-one,hexahydro-5-hydroxy-4-(hydroxymethyl)- (1S,5R)-(-)-2-OXABICYCLO[3.3.0]OCT-6-EN-3-ONE 4-(T-BUTYLDI-ME-SIO-ME)HEXA-H-5-(T-H-PYR AN -2-YLOXY)-CYCLOPENTA(B)FURAN-2-ON, 97 (3aR,4S,5R,6aS)-4-(hydroxyMethyl)-5-(triethylsilyloxy)-hexahydro-cyclopentafuran-2-one 2H-Cyclopenta[b]furan-2-one, hexahydro-4-(hydroxymethyl)-5-[(tetrahydro-2H-pyran-2-yl)oxy]-, (3aR,4S,5R,6aS)- (-)-Corey Lactone Diol Trelagliptin succinate (3-TRIFLUOROMETHYLPHENOXY) ACETIC ACID ETHYL ESTER (R)-4-fluoro-2-((3-methyl-2,4-dioxo-6-(piperidin-3-ylamino)-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile Travoprost Impurity 19 TrifluoroMethyl Dechloro 2-((6-chloro-3-Methyl-2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)Methyl)-4-fluorobenzonitrile (-)-Corey aldehyde benzoate (3-TRIFLUOROMETHYL-PHENOXY)-ACETIC ACID

5-(Benzoyloxy)hexahydro-4-(hydroxymethyl)-2H-cyclopenta[b]furan-2-one(3aα,4α,5β,6aα)

(-)-5-(BENZOYLOXY)HEXAHYDRO-4-(HYDROXYME)-2H-CYCLOPENTA(B)FURAN-2-ONE, 97%

5-(BENZOYLOXY) HEXAHYDRO-4-(HYDROXYMETHYL)-2H-CYCLOPENTA[B]FURAN-2-ONE

BENZOYL COREY LACTONE

(-)-COREY LACTONE BENZOATE 99%

(-)-COREY LACTONE BENZOATE: (3AR,4S,5R,6AS)-(-)-5-(BENZOYLOXY)-HEXAHYDRO-4(-HYDROXYMETHYL)-2H-CYCLOPENTA[B]FURAN-2-ONE

(-)-6-BETA-HYDROXYMETHYL-7-ALPHA-BENZOYLOXY-CIS-2-OXABICYCLO[3.3.0]OCTAN-3-ONE(COREY''S LACTONE)

[3aR-(3aα,4α,5β,6aα)]-5-(Benzoyloxy)hexahydro-4-(hydroxyMethyl)-2H-cyclopenta[b]furan-2-one

PGX 4

(1R)-2β-(Hydroxymethyl)-3α-(benzoyloxy)-5α-hydroxycyclopentane-1α-acetic acid 1,5-lactone

(1S,5R,6S,7R)-7-Benzoyloxy-6-hydroxymethyl-2-oxabicyclo[3.3.0]octan-3-one

(3aβ,6aβ)-4β-(Hydroxymethyl)-5α-(benzoyloxy)hexahydro-2H-cyclopenta[b]furan-2-one

(3aR,4S,5R,6aS)-4-(hydroxyMethyl)-2-oxohexahydro-2H-cyclopenta[b]furan-5-yl benzoate

(-) Corey Alcohol Benzoate

(3AR,4S,5R,6AS)-(-)-5-(BENZOYLOXY)-HEXAHYDRO-4(-HYDROXYMETHYL)-2H-CYCLOPENTA[B]FURAN-2-ONE

5-(BENZOYLOXY) HEXAHYDRO-4-(HYDROXYMETHYL)-2H-CYCLOPENTA[B]FURAN-2-ONE (3AA,4A,5BETA,6AA)

(-)-6-BETA-HYDROXYMETHYL-7-ALPHA-BENZOYLOXY-CIS-2-OXABICYCLO[3.3.0]OCTAN-3-ONE

(-)-5-(benzoyloxy)hexahydro-4-(hydroxyme)-2H-cycl

[3aR-(3aalpha,4alpha,5beta,6aalpha)]-hexahydro-4-(hydroxymethyl)-2-oxo-2H-cyclopenta[b]furan-5-yl benzoate

(-)-Corey Lactone Benzoate Basic information

2H-Cyclopenta[b]furan-2-one, 5-(benzoyloxy)hexahydro-4-(hydroxymethyl)-, (3aR,4S,5R,6aS)-

BCOD

COREY'S LACTONE

benzoic acid [4-(hydroxymethyl)-2-oxo-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-5-yl] ester

lactone benzoate

(-)-Corey Lactone Benzoate in stock Factory

[(3aR,4S,5R,6aS)-4-(hydroxymethyl)-2-oxo-3,3a,4,5,6,6a-hexahydrocyclopenta[b]furan-5-yl] benzoate

(-)-Corey Lactone Benzoate &gt

Travoprost Impurity 31

Travoprost Impurity 54

(-)corey lactone benzoate

(-)-Corey Lactone Benzoate USP/EP/BP

(-)-Corey lactone benzoate(For export only)

Tafluprost Impurity 11 (Corey lactone benzoate)

(-)-Corey Lactone Benzoate

BCOD (-)-Corey Lactone Benzoate 39746-00-4

Iloprost Impurity 16

(-) - Benzoic acid corylilide

(-) Benzoyl lactone

Benzoic acid lactone

39746-00-4

39746-60-4

Latanoprost

Prostaglandins