5-FORMYL-2-METHOXY-4-PICOLINE
- Product Name
- 5-FORMYL-2-METHOXY-4-PICOLINE
- CAS No.
- 123506-66-1
- Chemical Name
- 5-FORMYL-2-METHOXY-4-PICOLINE
- Synonyms
- CML-015;5-FORMYL-2-METHOXY-4-PICOLINE;2-Fluoro-37-(methylthio)pyridine;6-methoxy-4-methylnicotinaldehyde;6-Methoxy-4-methyl-3-pyridinecarboxaldehyde;3-Pyridinecarboxaldehyde, 6-methoxy-4-methyl-;3-Pyridinecarboxaldehyde, 6-methoxy-4-methyl- (9CI)
- CBNumber
- CB2284615
- Molecular Formula
- C8H9NO2
- Formula Weight
- 151.16
- MOL File
- 123506-66-1.mol
5-FORMYL-2-METHOXY-4-PICOLINE Property
- Melting point:
- 91-92 °C(Solv: hexane (110-54-3))
- Boiling point:
- 274.2±35.0 °C(Predicted)
- Density
- 1.123±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 2.25±0.18(Predicted)
- Appearance
- White to off-white Solid
N-Bromosuccinimide Price
- Product number
- Y3924
- Product name
- 5-Formyl-2-methoxy-4-picoline
- Packaging
- 250mg
- Price
- $118
- Updated
- 2021/12/16
- Product number
- CHM0166308
- Product name
- 5-FORMYL-2-METHOXY-4-PICOLINE
- Purity
- 98.00%
- Packaging
- 5MG
- Price
- $501.08
- Updated
- 2021/12/16
- Product number
- A186626
- Product name
- 6-Methoxy-4-methylnicotinaldehyde
- Purity
- 95%
- Packaging
- 100mg
- Price
- $35
- Updated
- 2021/12/16
- Product number
- A186626
- Product name
- 6-Methoxy-4-methylnicotinaldehyde
- Purity
- 95%
- Packaging
- 250mg
- Price
- $57
- Updated
- 2021/12/16
- Product number
- A186626
- Product name
- 6-Methoxy-4-methylnicotinaldehyde
- Purity
- 95%
- Packaging
- 1g
- Price
- $154
- Updated
- 2021/12/16
5-FORMYL-2-METHOXY-4-PICOLINE Chemical Properties,Usage,Production
Synthesis
68-12-2
164513-39-7
123506-66-1
General procedure for the synthesis of 5-formyl-2-methoxy-4-methyl-4-methylpyridine from 2-methoxy-4-methyl-5-bromopyridine and N,N-dimethylformamide: 5-bromo-2-methoxy-4-methylpyridine (2.6 g, 13 mmol) was dissolved in anhydrous THF (40 mL) and cooled to -70 °C under argon protection. A hexane solution of 1.6 M n-butyllithium (8.1 mL, 14 mmol) was slowly added over 10 min with stirring. The reaction temperature was maintained at -70 °C and stirring was continued for 30 min. Subsequently, anhydrous DMF (1.2 mL, 15 mmol) was added in batches, keeping the temperature constant. After addition, stirring was continued at -70 °C for 30 min, then brought to room temperature and stirred overnight. Upon completion of the reaction, the reaction was quenched with 1 M hydrochloric acid (40 mL) and subsequently extracted three times with tert-butyl methyl ether (TBME). The organic phases were combined, washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated. Purification by column chromatography using tert-butyl methyl ether-light petroleum ether (1:1) as eluent afforded 1.8 g (91% yield) of 5-formyl-2-methoxy-4-methylpyridine as a light yellow solid.LC-MS m/z 152 (M + 1); 1H NMR (CDCl3) δ 10.1 (s, 1H), 8.55 (s, 1H), 6.61 ( s, 1H), 4.05 (s, 3H), 2.60 (s, 3H) ppm.
References
[1] Patent: WO2006/65215, 2006, A1. Location in patent: Page/Page column 19; 35
[2] Synthetic Communications, 2009, vol. 39, # 17, p. 3060 - 3068
[3] Patent: WO2015/158427, 2015, A1. Location in patent: Page/Page column 84; 85
5-FORMYL-2-METHOXY-4-PICOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
5-FORMYL-2-METHOXY-4-PICOLINE Suppliers
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View Lastest Price from 5-FORMYL-2-METHOXY-4-PICOLINE manufacturers
- Product
- 5-Formyl-2-methoxy-4-picoline 123506-66-1
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2019-12-27
- Product
- 5-FORMYL-2-METHOXY-4-PICOLINE 123506-66-1
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-12