ST638
- Product Name
- ST638
- CAS No.
- 107761-24-0
- Chemical Name
- ST638
- Synonyms
- ST638;TYRPHOSTIN ST 638;α-cyano-(3-ethoxy-4-hydroxy-5-phenylthiomethyl)cinnamide;ALPHA-CYANO-(3-ETHOXY-4-HYDROXY-5-PHENYLTHIOMETHYL)CINNAMIDE;2-Cyano-3-[3-ethoxy-4-hydroxy-5-[(phenylthio)methyl]phenyl]propenamide;2-cyano-3-(3-ethoxy-4-hydroxy-5-((phenylthio)methyl)phenyl)-2-propenamid;2-cyano-3-(3-ethoxy-4-hydroxy-5-((phenylthio)methyl)phenyl)-2-propenamide;2-Propenamide, 2-cyano-3-[3-ethoxy-4-hydroxy-5-[(phenylthio)methyl]phenyl]-;(Z)-2-cyano-3-[3-ethoxy-4-hydroxy-5-(phenylsulfanylmethyl)phenyl]prop-2-enamide
- CBNumber
- CB2285405
- Molecular Formula
- C19H18N2O3S
- Formula Weight
- 354.42
- MOL File
- 107761-24-0.mol
ST638 Property
- Melting point:
- 134-135.5 °C
- Boiling point:
- 611.2±55.0 °C(Predicted)
- Density
- 1.32±0.1 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- DMSO: 19 mg/mL
- pka
- 8.79±0.50(Predicted)
- form
- solid
- color
- yellow
Safety
- WGK Germany
- 3
- RTECS
- UC6316200
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- S1195
- Product name
- ST638
- Purity
- ≥98% (HPLC), solid
- Packaging
- 5mg
- Price
- $271
- Updated
- 2024/03/01
- Product number
- 13337
- Product name
- ST638
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $38
- Updated
- 2024/03/01
- Product number
- 13337
- Product name
- ST638
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $166
- Updated
- 2024/03/01
- Product number
- 13337
- Product name
- ST638
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $292
- Updated
- 2024/03/01
- Product number
- 13337
- Product name
- ST638
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $638
- Updated
- 2024/03/01
ST638 Chemical Properties,Usage,Production
Uses
ST638 is a protein tyrosine kinase inhibitor and PLD inhibitor.
Biological Activity
st638 is a tyrosine kinase inhibitor [1].tyrosine kinases are a family of protein kinases that phosphorylate the serine and threonine on other proteins. phosphorylation of proteins by kinases has been involved in signal transduction and regulating cellular activity, such as cell division. tyrosine kinases function in a variety of processes, such as mitogenesis, induction of mitosis, and transmembrane signaling [2].in human platelets, preincubation with 50 μm of st638 completely blocked the platelet aggregation induced with 0.05 unit/ml of thrombin. st638 inhibited the increase of protein-tyrosine phosphorylation bands induced with thrombin in a dose-dependent manner. st638 blocked the platelet aggregation and protein-tyrosine phosphorylation induced with thrombin in aspirin-treated platelets [1]. in terminal erythroid differentiation of mouse erythroleukemia (mel) cells, st638 effectively induced differentiation in a synergistic manner [3]. in rat and rabbit pulmonary artery cells, st 638 (0.5 to 40 μmol/l) blocked ik in a dose-dependent manner [4].
References
[1] asahi m, yanagi s, ohta s, et al. thrombin-induced human platelet aggregation is inhibited by protein-tyrosine kinase inhibitors, st638 and genistein[j]. febs letters, 1992, 309(1): 10-14.
[2] levitzki a, gazit a. tyrosine kinase inhibition: an approach to drug development[j]. science, 1995, 267(5205): 1782.
[3] watanabe t, shiraishi t, sasaki h, et al. inhibitors for protein-tyrosine kinases, st638 and genistein, induce differentiation of mouse erythroleukemia cells in a synergistic manner[j]. experimental cell research, 1989, 183(2): 335-342.
[4] smirnov s v, aaronson p i. inhibition of vascular smooth muscle cell k+ currents by tyrosine kinase inhibitors genistein and st 638[j]. circulation research, 1995, 76(2): 310-316.
ST638 Preparation Products And Raw materials
Raw materials
Preparation Products
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