ST638

Product Name: ST638
CAS No.: 107761-24-0
Chemical Name: ST638
Synonyms: ST638;TYRPHOSTIN ST 638;α-cyano-(3-ethoxy-4-hydroxy-5-phenylthiomethyl)cinnamide;ALPHA-CYANO-(3-ETHOXY-4-HYDROXY-5-PHENYLTHIOMETHYL)CINNAMIDE;2-Cyano-3-[3-ethoxy-4-hydroxy-5-[(phenylthio)methyl]phenyl]propenamide;2-cyano-3-(3-ethoxy-4-hydroxy-5-((phenylthio)methyl)phenyl)-2-propenamid;2-cyano-3-(3-ethoxy-4-hydroxy-5-((phenylthio)methyl)phenyl)-2-propenamide;2-Propenamide, 2-cyano-3-[3-ethoxy-4-hydroxy-5-[(phenylthio)methyl]phenyl]-;(Z)-2-cyano-3-[3-ethoxy-4-hydroxy-5-(phenylsulfanylmethyl)phenyl]prop-2-enamide
CBNumber: CB2285405
Molecular Formula: C19H18N2O3S
Formula Weight: 354.42
MOL File: 107761-24-0.mol

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ST638 Property

Melting point:: 134-135.5 °C
Boiling point:: 611.2±55.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: −20°C
solubility: DMSO: 19 mg/mL
pka: 8.79±0.50(Predicted)
form: solid
color: yellow

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Safety

WGK Germany: 3
RTECS: UC6316200

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S1195
Product name: ST638
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $271
Updated: 2024/03/01

Cayman Chemical

Product number: 13337
Product name: ST638
Purity: ≥98%
Packaging: 1mg
Price: $38
Updated: 2024/03/01

Cayman Chemical

Product number: 13337
Product name: ST638
Purity: ≥98%
Packaging: 5mg
Price: $166
Updated: 2024/03/01

Cayman Chemical

Product number: 13337
Product name: ST638
Purity: ≥98%
Packaging: 10mg
Price: $292
Updated: 2024/03/01

Cayman Chemical

Product number: 13337
Product name: ST638
Purity: ≥98%
Packaging: 25mg
Price: $638
Updated: 2024/03/01

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ST638 Chemical Properties,Usage,Production

Uses

ST638 is a protein tyrosine kinase inhibitor and PLD inhibitor.

Biological Activity

st638 is a tyrosine kinase inhibitor [1].tyrosine kinases are a family of protein kinases that phosphorylate the serine and threonine on other proteins. phosphorylation of proteins by kinases has been involved in signal transduction and regulating cellular activity, such as cell division. tyrosine kinases function in a variety of processes, such as mitogenesis, induction of mitosis, and transmembrane signaling [2].in human platelets, preincubation with 50 μm of st638 completely blocked the platelet aggregation induced with 0.05 unit/ml of thrombin. st638 inhibited the increase of protein-tyrosine phosphorylation bands induced with thrombin in a dose-dependent manner. st638 blocked the platelet aggregation and protein-tyrosine phosphorylation induced with thrombin in aspirin-treated platelets [1]. in terminal erythroid differentiation of mouse erythroleukemia (mel) cells, st638 effectively induced differentiation in a synergistic manner [3]. in rat and rabbit pulmonary artery cells, st 638 (0.5 to 40 μmol/l) blocked ik in a dose-dependent manner [4].

References

[1] asahi m, yanagi s, ohta s, et al. thrombin-induced human platelet aggregation is inhibited by protein-tyrosine kinase inhibitors, st638 and genistein[j]. febs letters, 1992, 309(1): 10-14.
[2] levitzki a, gazit a. tyrosine kinase inhibition: an approach to drug development[j]. science, 1995, 267(5205): 1782.
[3] watanabe t, shiraishi t, sasaki h, et al. inhibitors for protein-tyrosine kinases, st638 and genistein, induce differentiation of mouse erythroleukemia cells in a synergistic manner[j]. experimental cell research, 1989, 183(2): 335-342.
[4] smirnov s v, aaronson p i. inhibition of vascular smooth muscle cell k+ currents by tyrosine kinase inhibitors genistein and st 638[j]. circulation research, 1995, 76(2): 310-316.

ST638 Preparation Products And Raw materials

Raw materials

Preparation Products

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ST638 Suppliers

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107761-24-0, ST638Related Search:

ST638 4-METHYL-2-[(METHYLTHIO)METHYL]PHENOL O-[(METHYLTHIO)METHYL]PHENOL 3-METHOXYCINNAMONITRILE

ST638

TYRPHOSTIN ST 638

2-cyano-3-(3-ethoxy-4-hydroxy-5-((phenylthio)methyl)phenyl)-2-propenamid

2-cyano-3-(3-ethoxy-4-hydroxy-5-((phenylthio)methyl)phenyl)-2-propenamide

ALPHA-CYANO-(3-ETHOXY-4-HYDROXY-5-PHENYLTHIOMETHYL)CINNAMIDE

α-cyano-(3-ethoxy-4-hydroxy-5-phenylthiomethyl)cinnamide

2-Cyano-3-[3-ethoxy-4-hydroxy-5-[(phenylthio)methyl]phenyl]propenamide

(Z)-2-cyano-3-[3-ethoxy-4-hydroxy-5-(phenylsulfanylmethyl)phenyl]prop-2-enamide

2-Propenamide, 2-cyano-3-[3-ethoxy-4-hydroxy-5-[(phenylthio)methyl]phenyl]-

107761-24-0

C19H18N2O3S

Cell Signaling and Neuroscience

BioChemical

Cell Biology

Kinase/Phosphatase Biology

Receptor Tyrosine Kinase Inhibitors

Vascular Endothelial Growth Factor Receptor (VEGFR)