Clomethiazole
- Product Name
- Clomethiazole
- CAS No.
- 533-45-9
- Chemical Name
- Clomethiazole
- Synonyms
- Distraneurin;CLOMETHIAZOLE;Clomethiazolum;Chlorethiazole;chlormethiazole;ChlormethiazoleHCl;CLOMETHIAZOLE HCL;Clomethiazole in methanol;5-(2-chloroethyl)-4-methylthiazole;Thiazole, 5-(2-chloroethyl)-4-methyl-
- CBNumber
- CB2286790
- Molecular Formula
- C6H8ClNS
- Formula Weight
- 161.65
- MOL File
- 533-45-9.mol
Clomethiazole Property
- Melting point:
- 127-128 °C
- Boiling point:
- bp7 92°
- Density
- d425 1.233
- refractive index
- 1.6000 (estimate)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- pKa 3.2 (Uncertain)
- form
- Oil
- color
- Pale Yellow
- CAS DataBase Reference
- 533-45-9(CAS DataBase Reference)
- NIST Chemistry Reference
- Clomethiazole(533-45-9)
Safety
- HS Code
- 2934100090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
H335May cause respiratory irritation
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C587020
- Product name
- Clomethiazolum
- Packaging
- 2g
- Price
- $450
- Updated
- 2021/12/16
- Product number
- C587020
- Product name
- Clomethiazolum
- Packaging
- 5g
- Price
- $675
- Updated
- 2021/12/16
- Product number
- CS-0103601
- Product name
- Clomethiazole
- Purity
- 98.19%
- Packaging
- 100mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- FC16096
- Product name
- Chlormethiazole
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FC16096
- Product name
- Chlormethiazole
- Packaging
- 2g
- Price
- $100
- Updated
- 2021/12/16
Clomethiazole Chemical Properties,Usage,Production
Uses
Hypnotic.
Uses
Clomethiazolum is a drug which is structurally related to thiamine (vitamin B1) but acts like a sedative, hypnotic, muscle relaxant and anticonvulsant.
Definition
ChEBI: 5-(2-chloroethyl)-4-methylthiazole is a member of thiazoles.
brand name
Clomiazin;Distraneurine;Emineurina;Gebriazol;Hemineurine;Heminevrin;Somnevrin.
World Health Organization (WHO)
Clomethiazole, which has sedative, anxiolytic and anticonvulsant activity, was introduced in 1960 for the treatment of acute alcohol withdrawal, delirium tremens, status epilepticus, eclamptic toxaemia, sleep disturbances in the elderly and agitation in psychogeriatic patients. It is also used as a sedative in certain anaesthetic procedures. There is little evidence of primary dependence in man but secondary dependence can occur in patients with a history of abuse of other substances, particularly alcohol. Dependence of this type has been reported as a result of inappropriate, long-term prescribing to outpatient alcoholics. Clomethiazole should not be prescribed to alcoholics who continue to drink. Adverse interactions with alcohol have been fatal. Although not controlled under the 1971 Convention on Psychotropic Substances, clomethiazole is subject to analogous controls in some countries.
Biological Activity
Sedative and anticonvulsant which is neuroprotective in a number of animal models. Prevents the degeneration of serotonergic nerve terminals induced by MDMA ('Ecstasy').
Clomethiazole Preparation Products And Raw materials
Raw materials
Preparation Products
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