ChemicalBook > CAS DataBase List > Droloxifene

Droloxifene

Product Name
Droloxifene
CAS No.
82413-20-5
Chemical Name
Droloxifene
Synonyms
k060;k060e;k21060e;K 21.060;DROLOXIFENE;e-droloxifene;3-hydroxytamoxifen;Droloxifene USP/EP/BP;(E)-3-Hydroxy Tamoxifen;Droloxifene, 10 mM in DMSO
CBNumber
CB2288512
Molecular Formula
C26H29NO2
Formula Weight
387.51
MOL File
82413-20-5.mol
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Droloxifene Property

Melting point:
127-129°C
storage temp. 
Amber Vial, -20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
color 
White to Pale Beige
Stability:
Light Sensitive
CAS DataBase Reference
82413-20-5(CAS DataBase Reference)
IARC
3 (Vol. 66) 1996
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H317May cause an allergic skin reaction

H351Suspected of causing cancer

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P281Use personal protective equipment as required.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P308+P313IF exposed or concerned: Get medical advice/attention.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P391Collect spillage. Hazardous to the aquatic environment

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
H954720
Product name
(E)-3-HydroxyTamoxifen
Packaging
10mg
Price
$125
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0002496
Product name
DROLOXIFENE
Purity
95.00%
Packaging
2.5MG
Price
$687.5
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
11035
Product name
3-HydroxyTamoxifen
Packaging
2.5mg
Price
$875
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0002496
Product name
DROLOXIFENE
Purity
95.00%
Packaging
25MG
Price
$1732.5
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
11035
Product name
3-HydroxyTamoxifen
Packaging
12.5mg
Price
$2000
Updated
2021/12/16
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Droloxifene Chemical Properties,Usage,Production

Chemical Properties

Off-White to Pale-Beige Solid

Uses

A Tamoxifen derivative with antitumor effect on estrogen-dependent breast cancer cells

Uses

A Tamoxifen (T006000) derivative with antitumor effect on estrogen-dependent breast cancer cells.

Uses

anti-estrogen, anti-hyperlipoproteinemic, reduces bone loss

Definition

ChEBI: Droloxifene is a stilbenoid.

in vivo

Droloxifene (5-20 mg/kg; p.o.; daily for 4 weeks) increases BMD of DFM at 10mg/kg, and completely prevents the decrease of BMC and BMD of DFM induced by ovariectomized (OVX) at 20 mg/kg/day[3].

Animal Model:5-month-old sham-operate rats[3]
Dosage:5, 10, 20 mg/kg
Administration:Oral; daily for 4 weeks
Result:BMD of DFM increased significantly at 10mg/kg; completely prevented the decrease of BMC and BMD of DFM induced by OVX at 20 mg/kg/day.

Droloxifene Preparation Products And Raw materials

Raw materials

Preparation Products

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Droloxifene Suppliers

Canada 1 China 44 Germany 1 India 2 Switzerland 1 United Kingdom 4 United States 13 Global 66
J & K SCIENTIFIC LTD.
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View Lastest Price from Droloxifene manufacturers

Dideu Industries Group Limited
Product
Droloxifene 82413-20-5
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons Min
Release date
2021-06-30
Shaanxi Dideu Medichem Co. Ltd
Product
Droloxifene 82413-20-5
Price
US $0.00-0.00/Kg
Min. Order
1KG
Purity
99.0%+
Supply Ability
800 tons
Release date
2020-04-29

82413-20-5, DroloxifeneRelated Search:

2-Ethoxyphenol Xylenol N,N-Dimethyl-1,4-phenylenediamine Tamoxifen Tamoxifen citrate Nonylphenol 4-Ethoxyphenol 4-Aminophenol PHENYL VALERATE Phenylhydrazine Chlorodimethylphenylsilane Phenol Phenol Red 2-Phenylphenol 3-Aminophenol 2-Aminophenol Folin-Phenol Reagent 4-HYDROXYTAMOXIFEN

  • (E)-3-[1-[4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL]-2-PHENYL-1-BUTENYL]-PHENOL CITRATE
  • DROLOXIFENE
  • 3-[1-[4-(2-dimethylaminoethoxy)phenyl]-2-phenyl-but-1-enyl]phenol
  • TAMOXIFEN, 3-HYDROXY-, CITRATE, (E)-
  • (e)-1-(4’-(2-dimethylaminoethoxy)phenyl)-1-(3’-hydroxyphenyl)-2-phenylbut-1-
  • (e)-3-(1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-phenyl-1-butenyl)phenol
  • (E)-α-[p-[2-(Dimethylamino)ethoxy]phenyl]-β-ethylstilben-3-ol
  • (E)-3-Hydroxy Tamoxifen
  • (e)-alpha-(para-(2-(dimethylamino)ethoxy)phenyl)-alpha’-ethyl-3-stilbenol
  • 3-hydroxytamoxifen
  • e-droloxifene
  • k060
  • k060e
  • k21060e
  • trans-1-(4-beta-dimethylaminoethoxyphenyl)-1-(3-hydroxyphenyl)-2-phenylbut-1
  • 3-[(1E)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol
  • K 21.060
  • Tamoxifen 3-Hydroxy trans-Isomer
  • Phenol, 3-[(1E)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-
  • Tamoxifen Citrate Impurity 22
  • Droloxifene USP/EP/BP
  • Droloxifene (3-Hydroxytamoxifen)
  • (E)-3-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol
  • Droloxifene, 10 mM in DMSO
  • Tamoxifen Citrate Impurity 19
  • 82413-20-5
  • C26H29NO2C6H8O7
  • Drug Analogues
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Aromatics