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2-(TRIMETHYLSILYLETHYNYL)PYRIDINE

Product Name
2-(TRIMETHYLSILYLETHYNYL)PYRIDINE
CAS No.
86521-05-3
Chemical Name
2-(TRIMETHYLSILYLETHYNYL)PYRIDINE
Synonyms
TIMTEC-BB SBB009057;TriMethylsilylethynyl)pyridin;2-(Trimethylsilyethynyl)pyridine;(2-Pyridylethynyl)trimethylsilane;2-(TRIMETHYLSILYLETHYNYL)PYRIDINE;2-(Trimethlysilyl-ethynyl)pyridine;2-(Trimethylsilylethynyl)pyridine,97%;trimethyl(2-pyridin-2-ylethynyl)silane;Pyridine, 2-[2-(trimethylsilyl)ethynyl]-;Pyridine,2-[(trimethylsilyl)ethynyl]-(9CI)
CBNumber
CB2295453
Molecular Formula
C10H13NSi
Formula Weight
175.3
MOL File
86521-05-3.mol
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2-(TRIMETHYLSILYLETHYNYL)PYRIDINE Property

Melting point:
42 °C
Boiling point:
85 °C
Density 
0.95±0.1 g/cm3(Predicted)
refractive index 
1.5330
Flash point:
85-86°C/1mm
storage temp. 
Inert atmosphere,2-8°C
pka
4.29±0.19(Predicted)
form 
clear liquid
color 
Colorless to Light orange to Yellow
Water Solubility 
Insoluble in water.
BRN 
4176916
CAS DataBase Reference
86521-05-3
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
HS Code 
29333990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical
Product number
T3879
Product name
2-[(Trimethylsilyl)ethynyl]pyridine
Packaging
1G
Price
$33
Updated
2025/07/31
TCI Chemical
Product number
T3879
Product name
2-[(Trimethylsilyl)ethynyl]pyridine
Packaging
5G
Price
$114
Updated
2025/07/31
TRC
Product number
T896585
Product name
2-(Trimethylsilylethynyl)pyridine
Packaging
500mg
Price
$75
Updated
2021/12/16
GFS CHEMICALS
Product number
83422
Product name
2-TMSETHYNYLPYRIDINE
Packaging
25g
Price
$375.25
Updated
2021/12/16
Activate Scientific
Product number
AS27269
Product name
2-[(Trimethylsilyl)ethynyl]pyridine
Purity
97+%
Packaging
25g
Price
$425
Updated
2021/12/16
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2-(TRIMETHYLSILYLETHYNYL)PYRIDINE Chemical Properties,Usage,Production

Chemical Properties

Clear colorless to yellow liquid

Uses

2-(Trimethylsilylethynyl)pyridine is used as a pharmaceutical intermediate.

Synthesis

109-04-6

1066-54-2

86521-05-3

General procedure for the synthesis of 2-pyridinylalkynyltrimethylsilanes from 2-bromopyridine and trimethylsilylethynes: 100 mL of diisopropylamine solution containing 2-bromopyridine (4.74 g, 0.030 mol), CuI (0.14 g, 0.74 mmol), and Pd(PPh3)2Cl2 (0.52 g, 0.74 mmol) was added to a solution containing 2-bromopyridine (4.74 g, 0.030 mol), CuI (0.14 g, 0.74 mmol), and Pd(PPh3)2Cl2 (0.52 g, 0.74 mmol), protected by nitrogen. trimethylsilylacetylene (3.0 g, 0.030 mol). The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and the residue was purified to give 5.0 g (95% yield) of 2-(trimethylsilyl)ethynylpyridine.

References

[1] Synthesis, 1983, # 4, p. 312 - 314
[2] Canadian Journal of Chemistry, 2005, vol. 83, # 6-7, p. 716 - 727
[3] Phosphorus, Sulfur and Silicon and Related Elements, 2002, vol. 177, # 5, p. 1041 - 1045
[4] Patent: WO2006/93466, 2006, A1. Location in patent: Page/Page column 28
[5] Journal of Organometallic Chemistry, 2009, vol. 694, # 9-10, p. 1317 - 1324

2-(TRIMETHYLSILYLETHYNYL)PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(TRIMETHYLSILYLETHYNYL)PYRIDINE Suppliers

Belgium 1 China 58 Europe 1 France 1 Germany 3 India 4 Japan 1 United Kingdom 3 United States 16 Global 88
Fluorochem Ltd
Tel
--
Fax
--
Email
vernam@fluorochem.co.uk
Country
United Kingdom
ProdList
6375
Advantage
65
Fluorochem Ltd.
Tel
--
Fax
--
Email
enquiries@fluorochem.co.uk
Country
United Kingdom
ProdList
6401
Advantage
74
VWR International
Tel
--
Fax
--
Email
solutions@vwr.com
Country
United Kingdom
ProdList
6548
Advantage
82
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View Lastest Price from 2-(TRIMETHYLSILYLETHYNYL)PYRIDINE manufacturers

Career Henan Chemical Co
Product
2-(TRIMETHYLSILYLETHYNYL)PYRIDINE 86521-05-3
Price
US $1.00/KG
Min. Order
1KG
Purity
98% HPLC
Supply Ability
10 tons/month
Release date
2020-01-08

86521-05-3, 2-(TRIMETHYLSILYLETHYNYL)PYRIDINERelated Search:

3-(TRIMETHYLSILYLETHYNYL)PYRIDINE 4-(Trimethlysilyl-ethynyl)pyridine 2-[2-(TRIMETHYLSILYL)ETHYNYL]-4-PICOLINE 2-[2-(TRIMETHYLSILYL)ETHYNYL]-6-PICOLINE 2-[2-(TRIMETHYLSILYL)ETHYNYL]-5-PICOLINE 2,6-BIS(TRIMETHYLSILYLETHYNYL)PYRIDINE 4,6-DIMETHYL-2-TRIMETHYLSILANYLETHYNYL-NICOTINONITRILE 5-BROMO-2-[2-(TRIMETHYLSILYL)ETHYNYL]PYRIDINE 2-(TRIMETHYLSILYLETHYNYL)PYRIDINE 2-TRIMETHYLSILANYLETHYNYL-3-CYANOPYRIDINE 5-FLUORO-2-[2-(TRIMETHYLSILYL)ETHYNYL]PYRIDINE

  • TIMTEC-BB SBB009057
  • 2-(TRIMETHYLSILYLETHYNYL)PYRIDINE
  • 2-(Trimethylsilyethynyl)pyridine
  • Pyridine,2-[(trimethylsilyl)ethynyl]-(9CI)
  • 2-(Trimethlysilyl-ethynyl)pyridine
  • 2-(Trimethylsilylethynyl)pyridine,97%
  • TriMethylsilylethynyl)pyridin
  • 2-(TRIMETHYLSILYLETHYNYL)PYRIDINE, 97%2-(TRIMETHYLSILYLETHYNYL)PYRIDINE, 97%2-(TRIMETHYLSILYLETHYNYL)PYRIDINE, 97%
  • Pyridine, 2-[2-(trimethylsilyl)ethynyl]-
  • (2-Pyridylethynyl)trimethylsilane
  • trimethyl(2-pyridin-2-ylethynyl)silane
  • 2-((Trimethylsilyl)ethynyl)pyridine - [T53001]
  • 86521-05-3
  • C5H4NCCSiCH33
  • SILYL