5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER

Product Name: 5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER
CAS No.: 78606-80-1
Chemical Name: 5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER
Synonyms: BML-111;BML111,BML 111;6(R)-7-trihydroxymethyl Heptanoate;1,3-Benzodioxole-9-sulfonylchloride;(5S,6R)-METHYL 5,6,7-TRIHYDROXYHEPTANOATE;5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER;5(S),6(R)-trihydroxy-7-heptanoic acid, methyl ester;Heptanoic acid, 5,6,7-trihydroxy-, methyl ester, (5S,6R)-
CBNumber: CB2296632
Molecular Formula: C8H16O5
Formula Weight: 192.21
MOL File: Mol file

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5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER Property

Boiling point:: 360.8±42.0 °C(Predicted)
Density: 1?+-.0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: H2O: ≥20mg/mL
form: powder
pka: 13.74±0.20(Predicted)
color: white to beige
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0215
Product name: 5(S),6(R),7-Trihydroxyheptanoic acid methyl ester
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $560
Updated: 2022/05/15

Cayman Chemical

Product number: 10005032
Product name: 5(S),6(R)-7-trihydroxymethyl Heptanoate
Purity: ≥95%
Packaging: 1mg
Price: $57
Updated: 2024/03/01

Cayman Chemical

Product number: 10005032
Product name: 5(S),6(R)-7-trihydroxymethyl Heptanoate
Purity: ≥95%
Packaging: 5mg
Price: $249
Updated: 2024/03/01

Cayman Chemical

Product number: 10005032
Product name: 5(S),6(R)-7-trihydroxymethyl Heptanoate
Purity: ≥95%
Packaging: 10mg
Price: $437
Updated: 2024/03/01

Tocris

Product number: 5488
Product name: BML111
Packaging: 10
Price: $182
Updated: 2021/12/16

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5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER Chemical Properties,Usage,Production

Description

BML-111 (78606-80-1) novel truncated analog of lipoxin A4 which retains anti-inflammatory activity.1 Inhibits LTB4-induced leukocyte chemotaxis, IC50=5 nM).1 Attenuates hemorrhagic shock-induced acute lung injury in a rat model.2 Displays hepatoprotective effects in acetaminophen-induced liver injury in mice.3 Limits inflammatory damage in the cerebral cortex and helps maintain blood brain barrier integrity in a rat model of ischemic stroke.4 Attenuates renal ischemia/reperfusion injury via activation of p38 MAPK/PPARa/HO-1 pathway.5

Uses

5(S),6(R)-7-trihydroxymethyl Heptanoate is a potent lipoxin A4 agonist.

storage

Store at -20°C

References

1) Lee et al. (1991), Inhibition of leukotriene B4-induced neutrophil migration by lipoxin A4: structure-function relationships; Biochem. Biophys. Res. Commun., 180 1416 2) Li et al. (2013), BML-111 attenuates hemorrhagic shock-induced acute lung injury through inhibiting activation of mitogen-activated protein kinase pathway in rats; J. Surg. Res., 183 710 3) El-Agamy et al. (2014), Protective effects of BML-111 against acetaminophen-induced acute liver injury in mice; J. Physiol. Biochem., 70 141 4) Hawkins et al. (2014), Neurovascular protection by post-ischemic intravenous injections of the lipoxin A4 receptor agonist, BML-111, in a rat model of ischemic stroke; J. Neurochem., 129 130 5) Wu et al. (2016), BML-111-Attenuates renal Ischemia/Reperfusion Injury via Peroxisome Proliferator-Activates Receptor-α-Regulated Heme Oxygenase-1; Inflammation, 39 611

5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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78606-80-1, 5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTERRelated Search:

Zafirlukast 6-ISOPROPOXY-9-XANTHONE-2-CARBOXYLIC ACID Phytosphingosine Ginkgolide B

BML-111

5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER

(5S,6R)-METHYL 5,6,7-TRIHYDROXYHEPTANOATE

Heptanoic acid, 5,6,7-trihydroxy-, methyl ester, (5S,6R)-

6(R)-7-trihydroxymethyl Heptanoate

1,3-Benzodioxole-9-sulfonylchloride

5(S),6(R)-trihydroxy-7-heptanoic acid, methyl ester

BML111,BML 111

78606-80-1