5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER
- Product Name
- 5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER
- CAS No.
- 78606-80-1
- Chemical Name
- 5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER
- Synonyms
- T22526;BML-111;BML111,BML 111;BML-111, Lipoxin A4 agonist;6(R)-7-trihydroxymethyl Heptanoate;1,3-Benzodioxole-9-sulfonylchloride;methyl (5R,6R)-5,6,7-trihydroxyheptanoate;(5S,6R)-METHYL 5,6,7-TRIHYDROXYHEPTANOATE;5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER;5(S),6(R)-trihydroxy-7-heptanoic acid, methyl ester
- CBNumber
- CB2296632
- Molecular Formula
- C8H16O5
- Formula Weight
- 192.21
- MOL File
- Mol file
5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER Property
- Boiling point:
- 360.8±42.0 °C(Predicted)
- Density
- 1?+-.0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- H2O: ≥20mg/mL
- form
- powder
- pka
- 13.74±0.20(Predicted)
- color
- white to beige
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- SML0215
- Product name
- 5(S),6(R),7-Trihydroxyheptanoic acid methyl ester
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $560
- Updated
- 2022/05/15
- Product number
- 10005032
- Product name
- 5(S),6(R)-7-trihydroxymethyl Heptanoate
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $57
- Updated
- 2024/03/01
- Product number
- 10005032
- Product name
- 5(S),6(R)-7-trihydroxymethyl Heptanoate
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $249
- Updated
- 2024/03/01
- Product number
- 10005032
- Product name
- 5(S),6(R)-7-trihydroxymethyl Heptanoate
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $437
- Updated
- 2024/03/01
- Product number
- 5488
- Product name
- BML111
- Packaging
- 10
- Price
- $182
- Updated
- 2021/12/16
5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER Chemical Properties,Usage,Production
Description
BML-111 (78606-80-1) novel truncated analog of lipoxin A4 which retains anti-inflammatory activity.1 Inhibits LTB4-induced leukocyte chemotaxis, IC50=5 nM).1 Attenuates hemorrhagic shock-induced acute lung injury in a rat model.2 Displays hepatoprotective effects in acetaminophen-induced liver injury in mice.3 Limits inflammatory damage in the cerebral cortex and helps maintain blood brain barrier integrity in a rat model of ischemic stroke.4 Attenuates renal ischemia/reperfusion injury via activation of p38 MAPK/PPARa/HO-1 pathway.5
Uses
5(S),6(R)-7-trihydroxymethyl Heptanoate is a potent lipoxin A4 agonist.
storage
Store at -20°C
References
[1] TAK H. LEE. Inhibition of leukotriene B4-induced neutrophil migration by lipoxin A4: Structure-function relationships[J]. Biochemical and biophysical research communications, 1991, 180 3: Pages 1416-1421. DOI:10.1016/s0006-291x(05)81354-3
[2] MD H B L, PHD, PHD You S M, et al. BML-111 attenuates hemorrhagic shock-induced acute lung injury through inhibiting activation of mitogen-activated protein kinase pathway in rats[J]. Journal of Surgical Research, 2013, 183 2: Pages 710-719. DOI:10.1016/j.jss.2013.03.007
[3] DINA S EL-AGAMY Nareman M G Mirhan N Makled. Protective effects of BML-111 against acetaminophen-induced acute liver injury in mice.[J]. Journal of physiology and biochemistry, 2014, 70 1: 141-149. DOI:10.1007/s13105-013-0288-x
[4] KIMBERLY E. HAWKINS. Neurovascular protection by post-ischemic intravenous injections of the lipoxin A4 receptor agonist, BML-111, in a rat model of ischemic stroke[J]. Journal of Neurochemistry, 2013, 129 1: 130-142. DOI:10.1111/jnc.12607
[5] SHENG-HUA WU. BML-111 Attenuates Renal Ischemia/Reperfusion Injury Via Peroxisome Proliferator-Activated Receptor-α-Regulated Heme Oxygenase-1[J]. Inflammation, 2015, 39 1: 611-624. DOI:10.1007/s10753-015-0286-y
5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER Preparation Products And Raw materials
Raw materials
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