ChemicalBook > CAS DataBase List > 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE
5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE
- Product Name
- 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE
- CAS No.
- 145915-60-2
- Chemical Name
- 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE
- Synonyms
- DAPH-7;DAPH 2;CGP 53353;CGP-53353 solid;5,6-bis((4-fluorophenyl)amino)isoindoline-1,3-dione;PKCβII/EGFR Inhibitor - CAS 145915-60-2 - Calbiochem;5,6-BIS[(4-FLUOROPHENYL)AMINO]-2H-ISOINDOLE-1,3-DIONE;5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE;1H-Isoindole-1,3(2H)-dione, 5,6-bis[(4-fluorophenyl)amino]-;5,6-Bis[(4-fluorophenyl)amino]-2H-isoindole-1,3-dione, DAPH 2
- CBNumber
- CB2299648
- Molecular Formula
- C20H13F2N3O2
- Formula Weight
- 365.33
- MOL File
- 145915-60-2.mol
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5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE Property
- storage temp.
- 2-8°C
- solubility
- DMSO: >10mg/mL
- form
- solid
- color
- orange
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Safety
- WGK Germany
- 3
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 539652
- Product name
- CGP-53353
- Purity
- The PKC
- Packaging
- 2mg
- Price
- $272
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- C7866
- Product name
- CGP-53353
- Purity
- solid
- Packaging
- 5mg
- Price
- $313
- Updated
- 2022/05/15
Tocris
- Product number
- 2442
- Product name
- CGP53353
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $265
- Updated
- 2021/12/16
TRC
- Product number
- C583575
- Product name
- CGP53353
- Packaging
- 2.5mg
- Price
- $325
- Updated
- 2021/12/16
Usbiological
- Product number
- 254940
- Product name
- CGP 53353
- Packaging
- 10mg
- Price
- $531
- Updated
- 2021/12/16
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5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE Chemical Properties,Usage,Production
Uses
CGP 53353 inhibited tyrosine kinase activity of the EGF-R in five different human transitional cell carcinoma lines.
Definition
ChEBI: 5,6-bis(4-fluoroanilino)isoindole-1,3-dione is a member of phthalimides.
Biological Activity
Selective inhibitor of PKC β II (IC 50 values are 0.41 and 3.8 μ M for PKC β II and PKC β I respectively). Also inhibits prionogenic Sup35 fibrillization (IC 50 ~ 3.4 μ M) and inhibits de novo A β 42 assembly in vitro .
storage
Store at RT
5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE Preparation Products And Raw materials
Raw materials
Preparation Products
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145915-60-2, 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONERelated Search:
4-FLUORODIPHENYLAMINE
5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE
4,5-DIANILINOPHTHALIMIDE
3,4-Dimethyldiphenylamine