ChemicalBook > CAS DataBase List > 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE

5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE

Product Name
5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE
CAS No.
145915-60-2
Chemical Name
5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE
Synonyms
DAPH-7;DAPH 2;CGP 53353;CGP-53353 solid;CGP 53353, 10 mM in DMSO;5,6-bis((4-fluorophenyl)amino)isoindoline-1,3-dione;PKCβII/EGFR Inhibitor - CAS 145915-60-2 - Calbiochem;5,6-BIS[(4-FLUOROPHENYL)AMINO]-2H-ISOINDOLE-1,3-DIONE;5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE;1H-Isoindole-1,3(2H)-dione, 5,6-bis[(4-fluorophenyl)amino]-
CBNumber
CB2299648
Molecular Formula
C20H13F2N3O2
Formula Weight
365.33
MOL File
145915-60-2.mol
More
Less

5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE Property

storage temp. 
2-8°C
solubility 
DMSO: >10mg/mL
form 
solid
color 
orange
More
Less

Safety

WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
539652
Product name
CGP-53353
Purity
The PKC
Packaging
2mg
Price
$272
Updated
2024/03/01
Sigma-Aldrich
Product number
C7866
Product name
CGP-53353
Purity
solid
Packaging
5mg
Price
$313
Updated
2022/05/15
Tocris
Product number
2442
Product name
CGP53353
Purity
≥99%(HPLC)
Packaging
10
Price
$265
Updated
2021/12/16
TRC
Product number
C583575
Product name
CGP53353
Packaging
2.5mg
Price
$325
Updated
2021/12/16
Usbiological
Product number
254940
Product name
CGP 53353
Packaging
10mg
Price
$531
Updated
2021/12/16
More
Less

5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE Chemical Properties,Usage,Production

Uses

CGP 53353 inhibited tyrosine kinase activity of the EGF-R in five different human transitional cell carcinoma lines.

Definition

ChEBI: 5,6-bis(4-fluoroanilino)isoindole-1,3-dione is a member of phthalimides.

Biological Activity

Selective inhibitor of PKC β II (IC 50 values are 0.41 and 3.8 μ M for PKC β II and PKC β I respectively). Also inhibits prionogenic Sup35 fibrillization (IC 50 ~ 3.4 μ M) and inhibits de novo A β 42 assembly in vitro .

storage

Store at RT

5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE Suppliers

China 22 Europe 1 Germany 3 Switzerland 1 United Kingdom 2 United States 8 Global 37
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
BIOTREND GmbH
Tel
--
Fax
--
Email
jaeger@biotrend.com
Country
Germany
ProdList
249
Advantage
65
BIOTREND Chemicals AG
Tel
--
Fax
--
Email
info@biotrend.ch
Country
Germany
ProdList
1250
Advantage
62

145915-60-2, 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONERelated Search:

4-FLUORODIPHENYLAMINE 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE 4,5-DIANILINOPHTHALIMIDE 3,4-Dimethyldiphenylamine

  • CGP 53353
  • 5,6-BIS[(4-FLUOROPHENYL)AMINO]-1H-ISOINDOLE-1,3(2H)-DIONE
  • 5,6-BIS[(4-FLUOROPHENYL)AMINO]-2H-ISOINDOLE-1,3-DIONE
  • 5,6-Bis[(4-fluorophenyl)amino]-2H-isoindole-1,3-dione, DAPH 2
  • DAPH 2
  • DAPH-7
  • PKCβII/EGFR Inhibitor - CAS 145915-60-2 - Calbiochem
  • 1H-Isoindole-1,3(2H)-dione, 5,6-bis[(4-fluorophenyl)amino]-
  • CGP-53353 solid
  • 5,6-bis((4-fluorophenyl)amino)isoindoline-1,3-dione
  • CGP 53353, 10 mM in DMSO
  • 145915-60-2
  • C20H13F2N3O2
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Protein Kinase C (PKC)
  • Kinase/Phosphatase Biology
  • Serine/Threonine Kinase Inhibitors
  • Protein Kinase