METHYL 5-METHYLNICOTINATE

Product Name: METHYL 5-METHYLNICOTINATE
CAS No.: 29681-45-6
Chemical Name: METHYL 5-METHYLNICOTINATE
Synonyms: Methomyl Impurity 4;METHYL 5-METHYLNICOTINATE;Nicotinic Acid Impurity 29;Nicotine Related Compound 5;Methyl5-Methylnicotinate>Methyl5-methylnicotinate,94%;5-methylnicotin methyl ester;5-Methyl-nicotinic acid methyl ester;Methyl 5-methylpyridine-3-carboxylate;METHYL 5-METHYLNICOTINATE ISO 9001：2015 REACH
CBNumber: CB2300692
Molecular Formula: C8H9NO2
Formula Weight: 151.16
MOL File: 29681-45-6.mol

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METHYL 5-METHYLNICOTINATE Property

Melting point:: 46-48°C
Boiling point:: 90°C 3mm
Density: 1.104±0.06 g/cm3(Predicted)
Flash point:: 90°C/3mm
storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in Chloroform and Methanol.
pka: 3.49±0.20(Predicted)
form: Solid
color: White
BRN: 472498
InChI: InChI=1S/C8H9NO2/c1-6-3-7(5-9-4-6)8(10)11-2/h3-5H,1-2H3
InChIKey: KQILMMLAGGFMCM-UHFFFAOYSA-N
SMILES: C1=NC=C(C)C=C1C(OC)=O
CAS DataBase Reference: 29681-45-6

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Safety

Hazard Codes: Xi
Risk Statements: 36/38
Safety Statements: 26-36
HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: M2428
Product name: Methyl 5-Methylnicotinate
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $28
Updated: 2025/07/31

TCI Chemical

Product number: M2428
Product name: Methyl 5-Methylnicotinate
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $112
Updated: 2025/07/31

Usbiological

Product number: M3515
Product name: Methyl 5-Methylnicotinate
Packaging: 500mg
Price: $326
Updated: 2021/12/16

TRC

Product number: M323005
Product name: Methyl 5-Methylnicotinate
Packaging: 2g
Price: $150
Updated: 2021/12/16

Matrix Scientific

Product number: 057381
Product name: Methyl 5-methylnicotinate
Purity: 95%
Packaging: 25g
Price: $157
Updated: 2021/12/16

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METHYL 5-METHYLNICOTINATE Chemical Properties,Usage,Production

Chemical Properties

METHYL 5-METHYLNICOTINATE is White Crystalline Solid

Uses

METHYL 5-METHYLNICOTINATE is a metabolite of Nicotine. Used for the synthesis of (5-methylpyridin-3-yl)methanol, a key intermediate of Rupatadine fumarate.

Uses

5-Methyl-N?-nitrosonornicotine (5-MeNNN) was synthesized from methyl 5-methylnicotinate. 5-Methyl-N?-nitrosonornicotine is used as the starting material in organic compound synthesis.

Synthesis

67-56-1

3222-49-9

29681-45-6

S1, Preparation of methyl 5-methylnicotinate: Depending on the molar amount of 5-methylnicotinate, 16 equivalents of methanol were slowly added dropwise over a period of 20 minutes, followed by 3 equivalents of thionyl chloride. The reaction mixture was warmed up to 82°C and held at this temperature for 6 hours. Continuous stirring was required during the dropwise addition and during the holding phase. Upon completion of the reaction, the temperature was lowered to 55 °C and the excess methanol and thionyl chloride were removed by distillation under reduced pressure. The reaction mixture was cooled to room temperature and ice water was added to obtain solution A. The pH of solution A was adjusted with ammonia under ice bath conditions to 8. Subsequently, ethyl acetate was added for extraction. The separated ethyl acetate phase was dried by adding anhydrous sodium sulfate until the moisture content was reduced to 0.3% by weight. The dried solution was filtered and the ethyl acetate was removed by rotary evaporator to finally obtain methyl 5-methylnicotinate.

References

[1] Patent: EP2824103, 2015, A1. Location in patent: Paragraph 0039
[2] Patent: CN106560471, 2017, A. Location in patent: Paragraph 0054; 0060; 0066; 0072; 0078; 0084; 0090; 0096
[3] Heterocyclic Communications, 2015, vol. 21, # 4, p. 203 - 205
[4] Journal of Organic Chemistry, 1988, vol. 53, # 15, p. 3513 - 3521
[5] Biochemistry, 2010, vol. 49, # 49, p. 10421 - 10439

METHYL 5-METHYLNICOTINATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 5-METHYLNICOTINATE Suppliers

Americas 1 Canada 2 China 191 Europe 2 Germany 5 India 10 Japan 1 United Kingdom 5 United States 21 Global 238

J & K SCIENTIFIC LTD.

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View Lastest Price from METHYL 5-METHYLNICOTINATE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: METHYL 5-METHYLNICOTINATE 29681-45-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-07-05

Dideu Industries Group Limited

Product: METHYL 5-METHYLNICOTINATE 29681-45-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-10-26

Career Henan Chemical Co

Product: Methyl 5-methylnicotinate 29681-45-6
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1ton
Release date: 2020-01-10

29681-45-6, METHYL 5-METHYLNICOTINATERelated Search:

Methyl nicotinate Etoricoxib IMpurity Etoricoxib Impurity M Etoricoxib Impurity 11 Etoricoxib Impurity 18 Etoricoxib Impurity 10 Etoricoxib Impurity 12 Diethyl pyridine-3,5-dicarboxylate DIETHYL 2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLATE METHYL 4-METHYLNICOTINATE THIAZOPYR METHYL 6-CHLORO-4-(TRIFLUOROMETHYL)NICOTINATE METHYL 6-METHYLNICOTINATE,Methyl6-methylnicotinate,97+%,Methyl 6-methylnicotinate 97% Methyl 4-chloro-6-methylnicotinate METHYL 2-AMINO-5-METHYL-NICOTINIC ACID METHYL 2-METHYLNICOTINATE 2-PHENYL-NICOTINIC ACID METHYL ESTER METHYL6-(TRIFLUOROMETHYL)NICOTINATE

Methyl 5-methylpyridine-3-carboxylate

5-methylnicotin methyl ester

5-Methyl-nicotinic acid methyl ester

METHYL 5-METHYLNICOTINATE

Methyl 5-methylpyridine-3-carboxylate~5-Methylnicotinic acid methyl ester

3-Pyridinecarboxylicacid,5-methyl-,methylester(9CI)

Methyl 5-methylpyridine-3-carboxylate, 3-(Methoxycarbonyl)-5-methylpyridine

Methyl5-methylnicotinate,94%

Methyl5-Methylnicotinate&gt

Nicotine Related Compound 5

3-Pyridinecarboxylic acid, 5-methyl-, methyl ester

5-Methylpyridine-3-carboxylic Acid Methyl Ester

METHYL 5-METHYLNICOTINATE ISO 9001：2015 REACH

3-Oxazolidinecarboxylicacid,2,2-dimethyl-4-(2-oxoethyl)-,1,1-dimethylethylester,(7S)-

Nicotinic Acid Impurity 29

Methomyl Impurity 4

29681-45-6

Aromatics

Metabolites & Impurities

CARBOXYLICESTER

Nicotine Derivatives

Metabolites

Aromatics, Metabolites & Impurities, Nicotine Derivatives