Axitinib Impurity a

ChemicalBook > CAS DataBase List > Axitinib Impurity a

Product Name: Axitinib Impurity a
CAS No.: 1347304-18-0
Chemical Name: Axitinib Impurity a
Synonyms: Axitinib C;PF03482595);Axitinib M12;Axitinib Sulfoxide;Axitinib Impurity a;Axitinib metabolite M12;Axitinib sulfoxide (AG028458;N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfinyl]benzamide;N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]benzamide;Benzamide, N-methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-
CBNumber: CB23038983
Molecular Formula: C22H18N4O2S
Formula Weight: 402.47
MOL File: 1347304-18-0.mol

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Axitinib Impurity a Property

Melting point:: >225 (dec.)
Boiling point:: 720.6±60.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
form: Solid
pka: 11.70±0.40(Predicted)
color: Light Yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P281Use personal protective equipment as required.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28042
Product name: Axitinib Sulfoxide
Packaging: 1mg
Price: $62
Updated: 2024/03/01

Cayman Chemical

Product number: 28042
Product name: Axitinib Sulfoxide
Packaging: 5mg
Price: $211
Updated: 2024/03/01

TRC

Product number: A794885
Product name: AxitinibSulfoxide
Packaging: 10mg
Price: $345
Updated: 2021/12/16

AK Scientific

Product number: 5029EA
Product name: Axitinibsulfoxide
Packaging: 1mg
Price: $166
Updated: 2021/12/16

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Axitinib Impurity a Chemical Properties,Usage,Production

Description

Axitinib sulfoxide is a major inactive metabolite of the tyrosine kinase inhibitor axitinib . It is formed from axitinib primarily by the cytochrome P450 (CYP) isoform CYP3A4 with minor contributions from CYP3A5 and CYP2C19.

Uses

Axitinib Sulfoxide is a major metabolite of Axitinib (A794650), a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.

Axitinib Impurity a Preparation Products And Raw materials

Raw materials

Preparation Products

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1347304-18-0, Axitinib Impurity aRelated Search:

Axitinib Axitinib Impurity b BenzaMide, 2-[(3-iodo-1H-indazol-6-yl)thio]-N-Methyl- 3,6-DIIODO (1H)INDAZOLE Axitinib Impurity 3 Axitinib-13C-d3 Axitinib Impurity d Axitinib Impurity 23 Axitinib Impurity 26 Axitinib Impurity 10 Axitinib Impurity 4 Axitinib Impurity 20 Axitinib Impurity 18 Axitinib Impurity 13 2-(1H-indazol-6-ylthio)-N-Methyl- BenzaMide Axitinib Impurity 3 Axitinib Impurity 14 Axitinib Impurity 19

Axitinib Impurity a

Axitinib Sulfoxide

N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]benzamide

N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfinyl]benzamide

Axitinib Impurity 5/Axitinib Sulfoxide/N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-benzamide

Benzamide, N-methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-

Axitinib C

Axitinib sulfoxide (AG028458

PF03482595)

Axitinib M12

Axitinib metabolite M12

(E)-N-Methyl-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)sulfinyl)benzamide (Axitinib Impurity)

1347304-18-0