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Axitinib Impurity a

Product Name
Axitinib Impurity a
CAS No.
1347304-18-0
Chemical Name
Axitinib Impurity a
Synonyms
Axitinib C;PF03482595);Axitinib M12;Axitinib Sulfoxide;Axitinib Impurity a;Axitinib metabolite M12;Axitinib sulfoxide (AG028458;N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfinyl]benzamide;N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]benzamide;Benzamide, N-methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-
CBNumber
CB23038983
Molecular Formula
C22H18N4O2S
Formula Weight
402.47
MOL File
1347304-18-0.mol
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Axitinib Impurity a Property

Melting point:
>225 (dec.)
Boiling point:
720.6±60.0 °C(Predicted)
Density 
1.43±0.1 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
DMSO (Slightly), Methanol (Slightly, Heated)
form 
Solid
pka
11.70±0.40(Predicted)
color 
Light Yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P281Use personal protective equipment as required.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28042
Product name
Axitinib Sulfoxide
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
28042
Product name
Axitinib Sulfoxide
Packaging
5mg
Price
$211
Updated
2024/03/01
TRC
Product number
A794885
Product name
AxitinibSulfoxide
Packaging
10mg
Price
$345
Updated
2021/12/16
AK Scientific
Product number
5029EA
Product name
Axitinibsulfoxide
Packaging
1mg
Price
$166
Updated
2021/12/16
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Axitinib Impurity a Chemical Properties,Usage,Production

Description

Axitinib sulfoxide is a major inactive metabolite of the tyrosine kinase inhibitor axitinib . It is formed from axitinib primarily by the cytochrome P450 (CYP) isoform CYP3A4 with minor contributions from CYP3A5 and CYP2C19.

Uses

Axitinib Sulfoxide is a major metabolite of Axitinib (A794650), a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.

Axitinib Impurity a Preparation Products And Raw materials

Raw materials

Preparation Products

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Axitinib Impurity a Suppliers

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1347304-18-0, Axitinib Impurity aRelated Search:

Axitinib Axitinib Impurity b BenzaMide, 2-[(3-iodo-1H-indazol-6-yl)thio]-N-Methyl- 3,6-DIIODO (1H)INDAZOLE Axitinib Impurity 3 Axitinib-13C-d3 Axitinib Impurity d Axitinib Impurity 23 Axitinib Impurity 26 Axitinib Impurity 10 Axitinib Impurity 4 Axitinib Impurity 20 Axitinib Impurity 18 Axitinib Impurity 13 2-(1H-indazol-6-ylthio)-N-Methyl- BenzaMide Axitinib Impurity 3 Axitinib Impurity 14 Axitinib Impurity 19

  • Axitinib Impurity a
  • Axitinib Sulfoxide
  • N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]benzamide
  • N-methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfinyl]benzamide
  • Axitinib Impurity 5/Axitinib Sulfoxide/N-Methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-benzamide
  • Benzamide, N-methyl-2-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]sulfinyl]-
  • Axitinib C
  • Axitinib sulfoxide (AG028458
  • PF03482595)
  • Axitinib M12
  • Axitinib metabolite M12
  • (E)-N-Methyl-2-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)sulfinyl)benzamide (Axitinib Impurity)
  • 1347304-18-0