p38 MAPK-IN-1

Product Name: p38 MAPK-IN-1
CAS No.: 1006378-90-0
Chemical Name: p38 MAPK-IN-1
Synonyms: CS-2117;p38 MAPK-IN-4;p38 MAPK-IN-1;p-38 MAPK-IN-1,p38 MAPKIN1,p38 MAPK IN 1;1,7-Naphthyridine, 4-(2,4-difluorophenyl)-8-(2-methylphenyl)-, 7-oxide
CBNumber: CB23041442
Molecular Formula: C21H14F2N2O
Formula Weight: 348.35
MOL File: 1006378-90-0.mol

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p38 MAPK-IN-1 Property

Boiling point:: 527.0±50.0 °C(Predicted)
Density: 1.27±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 8.33 mg/mL (23.84 mM)
form: Solid
pka: 0.26±0.40(Predicted)
color: Off-white to yellow

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Apolloscientific

Product number: BISN0235
Product name: P38 mapk-in-1
Packaging: 1mg
Price: $203
Updated: 2021/12/16

ChemScene

Product number: CS-4225
Product name: p38MAPK-IN-1
Purity: 98.91%
Packaging: 5mg
Price: $420
Updated: 2021/12/16

Apolloscientific

Product number: BISN0235
Product name: P38 mapk-in-1
Packaging: 5mg
Price: $473
Updated: 2021/12/16

ChemScene

Product number: CS-4225
Product name: p38MAPK-IN-1
Purity: 98.91%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

Apolloscientific

Product number: BISN0235
Product name: P38 mapk-in-1
Packaging: 10mg
Price: $675
Updated: 2021/12/16

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p38 MAPK-IN-1 Chemical Properties,Usage,Production

Uses

p38 MAPK-IN-1 (Compound 4) is a novel potent and selective inhibitor of p38 MAPK with IC50 of 68 nM. p38 MAPK-IN-1 shows sustained levels, low clearance and good bioavailability.

in vivo

p38 MAPK-IN-1 (Compound 4; 1 mg/kg for iv and 10 mg/kg for po) has a t_1/2 of 7.4 hours and CL of 2.7 mL/min/kg for iv, and a C_max of 5.3 μM for po in male wistar rats^[1].
p38 MAPK-IN-1 dose-dependently inhibits TNFα production with an ED₅₀ of 0.5 mg/kg^[1].

Animal Model:	Male wistar rats^[1]
Dosage:	10 mg/kg for po and 1 mg/kg for iv (Pharmacokinetic Analysis)
Administration:	Po and iv
Result:	Had a t_1/2 of 7.4 hours and CL of 2.7 mL/min/kg for iv, and a C_max of 5.3 μM for po.

IC 50

p38 MAPK: 68 nM (IC₅₀)

References

[1] Lumeras W, et al. 1,7-Naphthyridine 1-oxides as novel potent and selective inhibitors of p38 mitogen activated protein kinase. J Med Chem. 2011 Nov 24;54(22):7899-910. DOI:10.1021/jm200975u

p38 MAPK-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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p38 MAPK-IN-1 Suppliers

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1006378-90-0, p38 MAPK-IN-1Related Search:

p38 MAPK-IN-1

CS-2117

p38 MAPK-IN-4

1,7-Naphthyridine, 4-(2,4-difluorophenyl)-8-(2-methylphenyl)-, 7-oxide

p-38 MAPK-IN-1,p38 MAPKIN1,p38 MAPK IN 1

1006378-90-0