ChemicalBook > CAS DataBase List > 2-[1-(3-Fluoro-phenyl)-cyclohexylamino]-pyrimidine-5-carboxylic acid hydroxyamide

2-[1-(3-Fluoro-phenyl)-cyclohexylamino]-pyrimidine-5-carboxylic acid hydroxyamide

Product Name
2-[1-(3-Fluoro-phenyl)-cyclohexylamino]-pyrimidine-5-carboxylic acid hydroxyamide
CAS No.
1375466-18-4
Chemical Name
2-[1-(3-Fluoro-phenyl)-cyclohexylamino]-pyrimidine-5-carboxylic acid hydroxyamide
Synonyms
ACY-775;ACY-77;CS-2821;ACY-775 (ACY 775;ACY-775, 10 mM in DMSO;ACY-775; ACY 775; ACY775.;ACY-775,Histone deacetylases,inhibit,Inhibitor,ACY 775,HDAC,ACY775;5-Pyrimidinecarboxamide, 2-[[1-(3-fluorophenyl)cyclohexyl]amino]-N-hydroxy-;2-[1-(3-Fluoro-phenyl)-cyclohexylamino]-pyrimidine-5-carboxylic acid hydroxyamide
CBNumber
CB23042717
Molecular Formula
C17H19FN4O2
Formula Weight
330.36
MOL File
1375466-18-4.mol
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2-[1-(3-Fluoro-phenyl)-cyclohexylamino]-pyrimidine-5-carboxylic acid hydroxyamide Property

Density 
1.342±0.06 g/cm3(Predicted)
storage temp. 
2-8°C(protect from light)
solubility 
DMSO:35.33(Max Conc. mg/mL);106.94(Max Conc. mM)
DMF:20.0(Max Conc. mg/mL);60.54(Max Conc. mM)
DMF:PBS (pH 7.2) (1:4):0.2(Max Conc. mg/mL);0.61(Max Conc. mM)
Ethanol:34.5(Max Conc. mg/mL);104.43(Max Conc. mM)
form 
A solid
pka
7.74±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
A305320
Product name
ACY-775
Packaging
10mg
Price
$235
Updated
2021/12/16
Adipogen Life Sciences
Product number
AG-CR1-3903-M005
Product name
ACY-775
Purity
≥95%(HPLC)
Packaging
5mg
Price
$490
Updated
2021/12/16
ChemScene
Product number
CS-7689
Product name
ACY-775
Purity
99.83%
Packaging
50mg
Price
$588
Updated
2021/12/16
ChemScene
Product number
CS-7689
Product name
ACY-775
Purity
99.83%
Packaging
2mg
Price
$108
Updated
2021/12/16
ChemScene
Product number
CS-7689
Product name
ACY-775
Purity
99.83%
Packaging
5mg
Price
$144
Updated
2021/12/16
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2-[1-(3-Fluoro-phenyl)-cyclohexylamino]-pyrimidine-5-carboxylic acid hydroxyamide Chemical Properties,Usage,Production

Uses

ACY-775 is a novel histone deacetylase 6-selective (HDAC6) inhibitor with antidepressant and pro-cognitive properties. ACY-775 inhibits HDAC6 with low nanomolar potency and a selectivity of 60- to 1500-fold over class I HDACs.

in vivo

Biodistribution profiles of ACY-738, ACY-775, and tubastatin A are examined after acute dosing at 5 or 50?mg/kg over 2?h. At t=30?min after acute 50?mg/kg injection, respective plasma levels of ACY-738 and ACY-775 are 515?ng/mL (1.9?μM) and 1359?ng/mL (4.1?μM). Elimination from plasma is rapid, with plasmatic half-life of 12?min and concentration below 10?ng/mL after 2?h. Nevertheless, areas under concentration time curves for brain and plasm calculated over 2?h for both ACY-738 and ACY-775 lead to ratios >1. When ACY-738 (5?mg/kg) or ACY-775 (50?mg/kg) are administered repeatedly in wild-type mice at 24?h, 4?h, and 30?min before killing, significant increases in α-tubulin acetylation are observed in all tested brain regions[2].

IC 50

HDAC6: 7.5 nM (IC50); HDAC1: 2123 nM (IC50); HDAC2: 2570 nM (IC50); HDAC3: 11223 nM (IC50)

2-[1-(3-Fluoro-phenyl)-cyclohexylamino]-pyrimidine-5-carboxylic acid hydroxyamide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-[1-(3-Fluoro-phenyl)-cyclohexylamino]-pyrimidine-5-carboxylic acid hydroxyamide Suppliers

China 52 United States 8 Global 60
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
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1375466-18-4, 2-[1-(3-Fluoro-phenyl)-cyclohexylamino]-pyrimidine-5-carboxylic acid hydroxyamideRelated Search:


  • ACY-775
  • 2-[1-(3-Fluoro-phenyl)-cyclohexylamino]-pyrimidine-5-carboxylic acid hydroxyamide
  • ACY-775; ACY 775; ACY775.
  • CS-2821
  • ACY-775 (ACY 775
  • ACY-77
  • 5-Pyrimidinecarboxamide, 2-[[1-(3-fluorophenyl)cyclohexyl]amino]-N-hydroxy-
  • ACY-775,Histone deacetylases,inhibit,Inhibitor,ACY 775,HDAC,ACY775
  • ACY-775, 10 mM in DMSO
  • 1375466-18-4