Mes-PEG5- THP
- Product Name
- Mes-PEG5- THP
- CAS No.
- 145927-73-7
- Chemical Name
- Mes-PEG5- THP
- Synonyms
- MS-PEG4-THP;Mes-PEG4- THP;Mes-PEG5- THP;CAS_145927-73-7;Mesylate-tetraethylene glycol-tetrahydropyran ether;MSPEG4THP,MS-PEG-4-THP,PROTAC Linkers,inhibit,MS PEG4 THP,Inhibitor;2-(2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethoxy)ethyl methanesulfonate;Ethanol, 2-[2-[2-[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethoxy]ethoxy]ethoxy]-, 1-methanesulfonate
- CBNumber
- CB23048724
- Molecular Formula
- C14H28O8S
- Formula Weight
- 356.43
- MOL File
- 145927-73-7.mol
Mes-PEG5- THP Property
- storage temp.
- Storage temp. 2-8°C
- form
- Liquid
- color
- Light yellow to light brown
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
Mes-PEG5- THP Chemical Properties,Usage,Production
Uses
MS-PEG4-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Biological Activity
MS-PEG4-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
IC 50
PEGs
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Mes-PEG5- THP Preparation Products And Raw materials
Raw materials
Preparation Products
Mes-PEG5- THP Suppliers
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