2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one

Product Name: 2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one
CAS No.: 635324-72-0
Chemical Name: 2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one
Synonyms: MDK24720;CTLA-4 - INHIBITO;CTLA-4 - INHIBITOR;CTLA-4 inhibitor 1;MDK 24720 (CTLA-4 inhibitor);B7-CD28 Interaction Inhibitor;B7/CD28 interaction inhibitor 1;B7/CD28 interaction inhibitor 1, 10 mM in DMSO;2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b;2-(4-fluorophenyl)-1,6-dihydro-6-methyl-4-[3-(trifluoromethyl)phenyl]dipyrazolo[3,4-b:3',4'-d]pyridin-3(2H)-one
CBNumber: CB23048865
Molecular Formula: C21H13F4N5O
Formula Weight: 427.35
MOL File: 635324-72-0.mol

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2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one Property

Boiling point:: 599.5±60.0 °C(Predicted)
Density: 1.54±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO: Soluble: =10 mg/ml
form: Solid
pka: 5.76±0.20(Predicted)
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Crysdot

Product number: CD11082858
Product name: 2-(4-Fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one
Purity: 97%
Packaging: 100mg
Price: $269
Updated: 2021/12/16

Ambeed

Product number: A338124
Product name: 2-(4-Fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one
Purity: 97%
Packaging: 100mg
Price: $302
Updated: 2021/12/16

DC Chemicals

Product number: DC8784
Product name: CTLA-4inhibitor
Purity: >98%
Packaging: 10mg
Price: $350
Updated: 2021/12/16

Alichem

Product number: 635324720
Product name: 2-(4-Fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one
Packaging: 50mg
Price: $352.8
Updated: 2021/12/16

Alichem

Product number: 635324720
Product name: 2-(4-Fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one
Packaging: 100mg
Price: $539
Updated: 2021/12/16

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2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one Chemical Properties,Usage,Production

Uses

B7/CD28 interaction inhibitor 1 (copmound 6b) is a potent B7.1-CD28 interaction inhibitor with an IC50 of 50 nM[1].

Biological Activity

MDK 24720 (CTLA-4 inhibitor, copmound 6b) is a Cytotoxic T-Lymphocyte-Associated protein 4 (CTLA-4, CD152) inhibitor with IC50 of 50 nM for B7.1–CD28 inhibition.

in vitro

Bivalent CTLA4 homodimers bridge bivalent B7.1 homodimers to form an unusually stable signaling complex. Blocking B7/CD28 interactions with monoclonal antibodies or soluble receptors results in immunosuppression and enhanced allograft survival, while B7/CTLA-4 blockade results in enhanced antitumor immune responses. The interaction of co-stimulatory antigen molecules on T cells with B7 molecules on presenting cells plays an important role in the activation of naive T cells. Consequently, agents that disrupt these interactions should have applications in treatment of transplant rejection as well as autoimmune diseases.

target

Target	Value
CD152 ()
B7.1–CD28 (Cell-free assay)	50 nM

References

[1] Green NJ, et al. Structure-activity studies of a series of dipyrazolo[3,4-b:3',4'-d]pyridin-3-ones binding to the immune regulatory protein B7.1. Bioorg Med Chem. 2003 Jul 3;11(13):2991-3013. DOI:10.1016/s0968-0896(03)00183-4

2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one Suppliers

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635324-72-0, 2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-oneRelated Search:

CTLA-4 - INHIBITOR

2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(6H)-one

CTLA-4 - INHIBITO

MDK24720

B7/CD28 interaction inhibitor 1

Dipyrazolo[3,4-b:3',4'-d]pyridin-3(2H)-one, 2-(4-fluorophenyl)-1,6-dihydro-6-methyl-4-[3-(trifluoromethyl)phenyl]-

2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,2-dihydrodipyrazolo[3,4-b

CTLA-4 inhibitor 1

B7/CD28 interaction inhibitor 1,antibodies,T-cell,Inhibitor,inhibit,CTLA-4,responses,immunosuppression,B7.1,B-7/CD28 interaction inhibitor 1,CD28

MDK 24720 (CTLA-4 inhibitor)

2-(4-fluorophenyl)-1,6-dihydro-6-methyl-4-[3-(trifluoromethyl)phenyl]dipyrazolo[3,4-b:3',4'-d]pyridin-3(2H)-one

B7/CD28 interaction inhibitor 1, 10 mM in DMSO

B7-CD28 Interaction Inhibitor

2-(4-fluorophenyl)-6-methyl-4-(3-(trifluoromethyl)phenyl)-1,6-dihydrodipyrazolo[3,4-b:3',4'-d]pyridin-3(2h)-one

635324-72-0

C21H13F4N5O