Bis-PEG2-PFP ester
- Product Name
- Bis-PEG2-PFP ester
- CAS No.
- 1314378-18-1
- Chemical Name
- Bis-PEG2-PFP ester
- Synonyms
- PFP-PEG2-PFP;Bis-PEG2-PFP ester;PEG2 BIS-PFP ESTER;Bis-dPEG??-PFP ester;Ethyleneglycol-1,2-bis(pentafluorophenyl 3-oxypropionate);Propanoic acid, 3,3'-[1,2-ethanediylbis(oxy)]bis-, 1,1'-bis(2,3,4,5,6-pentafluorophenyl) ester;2,3,4,5,6-pentafluorophenyl 3-{2-[3-oxo-3-(2,3,4,5,6-pentafluorophenoxy)propoxy]ethoxy}propanoate
- CBNumber
- CB23062410
- Molecular Formula
- C20H12F10O6
- Formula Weight
- 538.29
- MOL File
- 1314378-18-1.mol
N-Bromosuccinimide Price
- Product number
- P999863
- Product name
- Bis-PEG2-PFPEster
- Packaging
- 100mg
- Price
- $285
- Updated
- 2021/12/16
- Product number
- 10984
- Product name
- Bis-dPEG®₁₃-PFPester
- Packaging
- 100mg
- Price
- $275
- Updated
- 2021/12/16
- Product number
- PEG4020
- Product name
- Pfp-PEG(2)-Pfp
- Packaging
- 100mg
- Price
- $351
- Updated
- 2021/12/16
- Product number
- LIN0000140
- Product name
- BIS-PEG2-PFP ESTER
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $436
- Updated
- 2021/12/16
- Product number
- BIPG1275
- Product name
- Bis-PEG2-PFP ester
- Packaging
- 250mg
- Price
- $449
- Updated
- 2021/12/16
Bis-PEG2-PFP ester Chemical Properties,Usage,Production
Description
Bis-PEG2-PFP ester is an amine reactive PEG linker. The two PFP ester moieties can form stable amide bonds and have been found to be very stable because they are less susceptible to undergo hydrolysis. The hydrophilic PEG linker increases the water solubility of the compound in aqueous envionments. Longer PEG chains tend to have enhanced water solubility properties compared to shorter PEG chains.
Uses
Bis-PEG2-PFP ester is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Bis-PEG2-PFP ester is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].
IC 50
PEGs; Alkyl/ether; Non-cleavable Linker
References
[1] Matthew David DOROSKI, et al. Cytotoxic peptides and antibody drug conjugates thereof. WO2013072813A2.
[2] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005
Bis-PEG2-PFP ester Preparation Products And Raw materials
Raw materials
Preparation Products
Bis-PEG2-PFP ester Suppliers
- Tel
- --
- Fax
- --
- sales@apolloscientific.co.uk
- Country
- United Kingdom
- ProdList
- 6084
- Advantage
- 88