ChemicalBook > CAS DataBase List > Mal-PEG1-NHS ester
Mal-PEG1-NHS ester
- Product Name
- Mal-PEG1-NHS ester
- CAS No.
- 1807518-72-4
- Chemical Name
- Mal-PEG1-NHS ester
- Synonyms
- Mal-PEG1-SPA;CAS_1807518-72-4;Mal-PEG1-NHS ester;2,5-Dioxopyrrolidin-1-yl 3-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy)propanoate;Propanoic acid, 3-[2-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester;PROTAC,Antibody-drug conjugates linkers,Inhibitor,inhibit,PROTAC Linkers,Mal-PEG-1-NHS ester,PEG,Linker,ADC Linkers,Mal PEG1 NHS ester,ADC,MalPEG1NHS ester
- CBNumber
- CB23062526
- Molecular Formula
- C13H14N2O7
- Formula Weight
- 310.26
- MOL File
- 1807518-72-4.mol
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Mal-PEG1-NHS ester Property
- Boiling point:
- 488.4±55.0 °C(Predicted)
- Density
- 1.48±0.1 g/cm3(Predicted)
- solubility
- Soluble in DCM
- pka
- -2.35±0.20(Predicted)
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N-Bromosuccinimide Price
BroadPharm
- Product number
- BP-21854
- Product name
- Mal-PEG1-NHSester
- Purity
- 98%
- Packaging
- 100mg
- Price
- $320
- Updated
- 2021/12/16
BroadPharm
- Product number
- BP-21854
- Product name
- Mal-PEG1-NHSester
- Purity
- 98%
- Packaging
- 250mg
- Price
- $560
- Updated
- 2021/12/16
Apolloscientific
- Product number
- BIPG1502
- Product name
- Mal-PEG1-NHS ester
- Packaging
- 100mg
- Price
- $623
- Updated
- 2021/12/16
BroadPharm
- Product number
- BP-21854
- Product name
- Mal-PEG1-NHSester
- Purity
- 98%
- Packaging
- 500mg
- Price
- $890
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0107986
- Product name
- Mal-PEG1-NHSester
- Packaging
- 250mg
- Price
- $1700
- Updated
- 2021/12/16
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Mal-PEG1-NHS ester Chemical Properties,Usage,Production
Description
Mal-PEG1-NHS ester is a PEG linker containing a maleimide group and an NHS ester group. The hydrophilic PEG spacer increases solubility in aqueous media. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.
Biological Activity
Mal-PEG1-NHS ester is a cleavable PEG-based ADC linker for the synthesis of antibody drug conjugates (ADCs). It is a PEG-based PROTAC linker that can be used to synthesize PROTACs.
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Cleavable
| PEGs
|