Mal-PEG6-PFP

Product Name: Mal-PEG6-PFP
CAS No.: 1599486-33-5
Chemical Name: Mal-PEG6-PFP
Synonyms: Mal-PEG6-PFP;Mal-PEG6-PFP ester;perfluorophenyl 1-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3,6,9,12,15,18-hexaoxahenicosan-21-oate;4,7,10,13,16,19-Hexaoxaheneicosanoic acid, 21-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-, 2,3,4,5,6-pentafluorophenyl ester
CBNumber: CB23062546
Molecular Formula: C25H30F5NO10
Formula Weight: 599.5
MOL File: 1599486-33-5.mol

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Mal-PEG6-PFP Property

Boiling point:: 623.0±55.0 °C(Predicted)
Density: 1.353±0.06 g/cm3(Predicted)
solubility: Soluble in DMSO, DCM, DMF
pka: -2.34±0.20(Predicted)
form: Liquid
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Apolloscientific

Product number: BIPG1513
Product name: Mal-PEG6-PFP
Packaging: 100mg
Price: $797
Updated: 2021/12/16

BroadPharm

Product number: BP-21008
Product name: Mal-PEG6-PFP
Purity: 98%
Packaging: 1g
Price: $2500
Updated: 2021/12/16

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Mal-PEG6-PFP Chemical Properties,Usage,Production

Description

Mal-PEG6-PFP is a PEG linker with maleimide and PFP moieties. Maleimides are thiol reactive between pH 6.5 and 7.5, forming thiolester bonds. The PFP is amine reactive and forms stable amide bonds. PFP was also found to be less susceptible toward hydrolysis than other amine reactive groups. The hydrophilic PEG linker increases the water solubility of a compound in aqueous environments. Increasing the number of units in the PEG chain ehnahces their solubility properties.

Uses

Mal-PEG6-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs; Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Mal-PEG6-PFP Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Mal-PEG6-PFP manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Mal-PEG6-PFP ester 1599486-33-5
Price: US $0.00/mg
Min. Order: 250mg
Purity: >98.00%
Supply Ability: 250mg
Release date: 2024-03-27

1599486-33-5, Mal-PEG6-PFPRelated Search:

Mal-PEG5-PFP Mal-PEG3-PFP Mal-amido-PEG7-acid Mal-PEG12-acid 4,7,10,13,16,19,22,25,28,31,34,37,40,43,46,49,52,55,58,61,64,67,70,73,76,79,82,85-Octacosaoxa-88-azahennonacontanoic acid, 91-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-89-oxo-, 2,5-dioxo-1-pyrrolidinyl ester Mal-PEG3-alcohol Mal-amido-PEG8-Val-Gly INDEX NAME NOT YET ASSIGNED Mal-PEG4-Acid Mal-PEG3-Val-Cit-PAB-PNP Mal-PEG3-alcohol Mal-PEG4-PFP Mal-PEG1-Bromide Maleimido-Tri(Ethylene Glycol)-Propionic Acid Mal-amido-PEG12-TFP ester Mal-amido-PEG8-val-gly-PAB-OH Mal-PEG3-Val-Cit-PAB-OH Mal-PEG4-NHS ester

Mal-PEG6-PFP

Mal-PEG6-PFP ester

4,7,10,13,16,19-Hexaoxaheneicosanoic acid, 21-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-, 2,3,4,5,6-pentafluorophenyl ester

perfluorophenyl 1-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-3,6,9,12,15,18-hexaoxahenicosan-21-oate

1599486-33-5

C25H30F5NO10

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