ChemicalBook > CAS DataBase List > 4,6-dichloro-5-acetylpyrimidine

4,6-dichloro-5-acetylpyrimidine

Product Name
4,6-dichloro-5-acetylpyrimidine
CAS No.
60025-06-1
Chemical Name
4,6-dichloro-5-acetylpyrimidine
Synonyms
1-(4,6-Dichloropyrimidin-5-yl)ethanone;5-Acetyl-4,6-dichloropyrimidine;4,6-dichloro-5-acetylpyrimidine;1-(4,6-Dichloro-5-pyrimidinyl)ethenone;1-(4,6-DICHLORO-5-PYRIMIDINYL)ETHANONE;1-(4,6-dichloropyrimidin-5-yl)ethan-1-one;Ethanone, 1-(4,6-dichloro-5-pyrimidinyl)-;1-(4,6-Dichloro-5-pyrimidinyl)ethanone 95%
CBNumber
CB23104071
Molecular Formula
C6H4Cl2N2O
Formula Weight
191.01
MOL File
60025-06-1.mol
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4,6-dichloro-5-acetylpyrimidine Property

Melting point:
90-91 °C
Boiling point:
240.3±35.0 °C(Predicted)
Density 
1.454±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-6.16±0.26(Predicted)
Appearance
Yellow to orange Solid
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

TRC
Product number
B419393
Product name
1-(4,6-Dichloropyrimidin-5-yl)ethanone
Packaging
100mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD164099
Product name
1-(4,6-Dichloropyrimidin-5-yl)ethanone
Packaging
500mg
Price
$100
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD164099
Product name
1-(4,6-Dichloropyrimidin-5-yl)ethanone
Packaging
1g
Price
$150
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD164099
Product name
1-(4,6-Dichloropyrimidin-5-yl)ethanone
Packaging
2g
Price
$250
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD164099
Product name
1-(4,6-Dichloropyrimidin-5-yl)ethanone
Packaging
5G
Price
$350
Updated
2021/12/16
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4,6-dichloro-5-acetylpyrimidine Chemical Properties,Usage,Production

Synthesis

60025-05-0

60025-06-1

General procedure for the synthesis of 1-(4,6-dichloropyrimidin-5-yl)ethanone using 1-(4,6-dichloropyrimidin-5-yl)ethanol as starting material: 1-(4,6-dichloropyrimidin-5-yl)ethanol (8.95 g, 46.4 mmol) was dissolved in 140 mL of acetone and chromium trioxide (9.27 g, 92.7 mmol) was added. The reaction mixture was stirred at room temperature for 2.5 hours. Subsequently, the reaction was quenched by the addition of 15 mL of isopropanol and stirring was continued for 15 minutes. The reaction mixture was slowly poured into 500 mL of saturated sodium bicarbonate solution at 0°C. The aqueous phase was extracted three times with dichloromethane, and the organic phases were combined and dried with anhydrous sodium sulfate. After drying, the organic phase was concentrated to give a crude product of 8.02 g. Purification of the crude product by silica gel column chromatography with 10% ethyl acetate/hexane as eluent afforded the pure 1-(4,6-dichloropyrimidin-5-yl)ethanone 7.62 g in 86% yield. HPLC analysis showed a retention time of 4.92 min (HPLC condition H).

References

[1] Patent: US2009/286812, 2009, A1. Location in patent: Page/Page column 23-24
[2] Patent: WO2006/90261, 2006, A1. Location in patent: Page/Page column 79
[3] Patent: US2018/105527, 2018, A1. Location in patent: Paragraph 0803-0805
[4] Patent: WO2010/9207, 2010, A1. Location in patent: Page/Page column 57-58

4,6-dichloro-5-acetylpyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4,6-dichloro-5-acetylpyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4,6-dichloro-5-acetylpyrimidine 60025-06-1
Price
US $0.10-10.00/KG
Min. Order
0.10000000149011612KG
Purity
98%
Supply Ability
200TONS
Release date
2025-08-14
Henan Aochuang Chemical Co.,Ltd.
Product
4,6-dichloro-5-acetylpyrimidine 60025-06-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-19
Career Henan Chemica Co
Product
4,6-dichloro-5-acetylpyrimidine 60025-06-1
Price
US $1.00/g
Min. Order
1g
Purity
85.0-99.8%
Supply Ability
20tons
Release date
2020-10-28

60025-06-1, 4,6-dichloro-5-acetylpyrimidineRelated Search:


  • 4,6-dichloro-5-acetylpyrimidine
  • 1-(4,6-dichloropyrimidin-5-yl)ethan-1-one
  • 1-(4,6-Dichloropyrimidin-5-yl)ethanone
  • 1-(4,6-DICHLORO-5-PYRIMIDINYL)ETHANONE
  • 5-Acetyl-4,6-dichloropyrimidine
  • Ethanone, 1-(4,6-dichloro-5-pyrimidinyl)-
  • 1-(4,6-Dichloro-5-pyrimidinyl)ethenone
  • 1-(4,6-Dichloro-5-pyrimidinyl)ethanone 95%
  • 60025-06-1