4,6-dichloro-5-acetylpyrimidine
- Product Name
- 4,6-dichloro-5-acetylpyrimidine
- CAS No.
- 60025-06-1
- Chemical Name
- 4,6-dichloro-5-acetylpyrimidine
- Synonyms
- 1-(4,6-Dichloropyrimidin-5-yl)ethanone;5-Acetyl-4,6-dichloropyrimidine;4,6-dichloro-5-acetylpyrimidine;1-(4,6-Dichloro-5-pyrimidinyl)ethenone;1-(4,6-DICHLORO-5-PYRIMIDINYL)ETHANONE;1-(4,6-dichloropyrimidin-5-yl)ethan-1-one;Ethanone, 1-(4,6-dichloro-5-pyrimidinyl)-;1-(4,6-Dichloro-5-pyrimidinyl)ethanone 95%
- CBNumber
- CB23104071
- Molecular Formula
- C6H4Cl2N2O
- Formula Weight
- 191.01
- MOL File
- 60025-06-1.mol
4,6-dichloro-5-acetylpyrimidine Property
- Melting point:
- 90-91 °C
- Boiling point:
- 240.3±35.0 °C(Predicted)
- Density
- 1.454±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -6.16±0.26(Predicted)
- Appearance
- Yellow to orange Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- B419393
- Product name
- 1-(4,6-Dichloropyrimidin-5-yl)ethanone
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FD164099
- Product name
- 1-(4,6-Dichloropyrimidin-5-yl)ethanone
- Packaging
- 500mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FD164099
- Product name
- 1-(4,6-Dichloropyrimidin-5-yl)ethanone
- Packaging
- 1g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- FD164099
- Product name
- 1-(4,6-Dichloropyrimidin-5-yl)ethanone
- Packaging
- 2g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- FD164099
- Product name
- 1-(4,6-Dichloropyrimidin-5-yl)ethanone
- Packaging
- 5G
- Price
- $350
- Updated
- 2021/12/16
4,6-dichloro-5-acetylpyrimidine Chemical Properties,Usage,Production
Synthesis
60025-05-0
60025-06-1
General procedure for the synthesis of 1-(4,6-dichloropyrimidin-5-yl)ethanone using 1-(4,6-dichloropyrimidin-5-yl)ethanol as starting material: 1-(4,6-dichloropyrimidin-5-yl)ethanol (8.95 g, 46.4 mmol) was dissolved in 140 mL of acetone and chromium trioxide (9.27 g, 92.7 mmol) was added. The reaction mixture was stirred at room temperature for 2.5 hours. Subsequently, the reaction was quenched by the addition of 15 mL of isopropanol and stirring was continued for 15 minutes. The reaction mixture was slowly poured into 500 mL of saturated sodium bicarbonate solution at 0°C. The aqueous phase was extracted three times with dichloromethane, and the organic phases were combined and dried with anhydrous sodium sulfate. After drying, the organic phase was concentrated to give a crude product of 8.02 g. Purification of the crude product by silica gel column chromatography with 10% ethyl acetate/hexane as eluent afforded the pure 1-(4,6-dichloropyrimidin-5-yl)ethanone 7.62 g in 86% yield. HPLC analysis showed a retention time of 4.92 min (HPLC condition H).
References
[1] Patent: US2009/286812, 2009, A1. Location in patent: Page/Page column 23-24
[2] Patent: WO2006/90261, 2006, A1. Location in patent: Page/Page column 79
[3] Patent: US2018/105527, 2018, A1. Location in patent: Paragraph 0803-0805
[4] Patent: WO2010/9207, 2010, A1. Location in patent: Page/Page column 57-58
4,6-dichloro-5-acetylpyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
4,6-dichloro-5-acetylpyrimidine Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from 4,6-dichloro-5-acetylpyrimidine manufacturers
- Product
- 4,6-dichloro-5-acetylpyrimidine 60025-06-1
- Price
- US $0.10-10.00/KG
- Min. Order
- 0.10000000149011612KG
- Purity
- 98%
- Supply Ability
- 200TONS
- Release date
- 2025-08-14
- Product
- 4,6-dichloro-5-acetylpyrimidine 60025-06-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1ton
- Release date
- 2022-09-19
- Product
- 4,6-dichloro-5-acetylpyrimidine 60025-06-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 85.0-99.8%
- Supply Ability
- 20tons
- Release date
- 2020-10-28