ChemicalBook > CAS DataBase List > BMS-582949 (hydrochloride)

BMS-582949 (hydrochloride)

Product Name
BMS-582949 (hydrochloride)
CAS No.
912806-16-7
Chemical Name
BMS-582949 (hydrochloride)
Synonyms
BMS-582949 (hydrochloride);BMS 582949,BMS 582949 hydrochloride,Inhibitor,BMS582949,Autophagy,BMS-582949,inhibit,BMS582949 hydrochloride,p38 MAPK
CBNumber
CB23126697
Molecular Formula
C22H27ClN6O2
Formula Weight
442.94178
MOL File
912806-16-7.mol
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BMS-582949 (hydrochloride) Property

storage temp. 
Store at -20°C
solubility 
≥44.3 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥2.7 mg/mL in EtOH with gentle warming and ultrasonic
form 
solid
color 
White to off-white
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ApexBio Technology
Product number
B7850
Product name
BMS-582949hydrochloride
Packaging
5mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-5621
Product name
BMS-582949hydrochloride
Purity
98.82%
Packaging
5mg
Price
$150
Updated
2021/12/16
Apolloscientific
Product number
BISN0242
Product name
BMS-582949hydrochloride
Packaging
5mg
Price
$203
Updated
2021/12/16
ChemScene
Product number
CS-5621
Product name
BMS-582949hydrochloride
Purity
98.82%
Packaging
25mg
Price
$500
Updated
2021/12/16
Apolloscientific
Product number
BISN0242
Product name
BMS-582949hydrochloride
Packaging
25mg
Price
$682
Updated
2021/12/16
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BMS-582949 (hydrochloride) Chemical Properties,Usage,Production

Biological Activity

bms-582949 hydrochloride is a novel, potent and highly selective p38α mitogen-activated protein kinase (p38α mapk) inhibitor [1].the p38α map kinase plays a critical role in regulating the production of many inflammatory cytokines, including tnf-α and il-1β. excessive production of tnf-α and il-1β has been implicated in many inflammatory diseases [1].bms-582949 hydrochloride potently inhibited the activity of p38α mapk with the ic50 value of 13 nm [1]. bms-582949 showed no significant effects on cytochrome p450 isozymes 1a2, 2c9, 2c19, and 2d6 with the ic50 values of >40 μm. bms-582949 weakly inhibited the activity of cyp3a4, with the ic50 value of 18-40 μm. bms-582949 displayed >2000-fold selectivity for p38α over a diverse panel of 57 kinases, include serine kinases, receptor tyrosine kinases, nonreceptor tyrosine kinases, and the p38γ and δ isoforms. bms-582949 showed 450-fold selectivity over jnk2, a map kinase involved in inflammation, and 190-fold selective over raf [1]. in mice, after oral administration of bms-582949 (10 mg/kg), the clearance rate for bms-582949 is 4.4 ml/min/kg. bms-582949 exhibited oral bioavailability values of 90% and 60% in mice and rats, respectively [1].bms-582949 is currently under phase ii

References

[1] liu c, lin j, wrobleski s t, et al. discovery of 4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-n-propylpyrrolo [1, 2-f][1, 2, 4] triazine-6-carboxamide (bms-582949), a clinical p38α map kinase inhibitor for the treatment of inflammatory diseases[j]. journal of medicinal chemistry, 2010, 53(18): 6629-6639.
[2] emami h, vucic e, subramanian s, et al. the effect of bms-582949, a p38 mitogen-activated protein kinase (p38 mapk) inhibitor on arterial inflammation: a multicenter fdg-pet trial[j]. atherosclerosis, 2015, 240(2): 490-496.

BMS-582949 (hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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BMS-582949 (hydrochloride) Suppliers

Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
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61
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
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ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
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China
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Shanghai Chaolan Chemical Technology Center
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021-QQ:65489617 15618227136
Fax
21-5161 9052
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Sales@ATKchemical.com
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China
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Beijing Solarbio Science & Tecnology Co., Ltd.
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010-50973130 4009686088
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3193328036@qq.com
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China
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29785
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Amadis Chemical Company Limited
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571-89925085
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0086-571-89925065
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sales@amadischem.com
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China
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131957
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Musechem
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+1-800-259-7612
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+1-800-259-7612
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United States
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Angel Pharmatech, Ltd.
Tel
17317130613
Fax
QQ3358272972
Email
3358272972@qq.com
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China
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3253
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TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
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32161
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58
InvivoChem
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+1-708-310-1919 +1-13798911105
Fax
708-557-7486
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sales@invivochem.cn
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United States
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6391
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912806-16-7, BMS-582949 (hydrochloride)Related Search:


  • BMS-582949 (hydrochloride)
  • BMS 582949,BMS 582949 hydrochloride,Inhibitor,BMS582949,Autophagy,BMS-582949,inhibit,BMS582949 hydrochloride,p38 MAPK
  • 912806-16-7
  • C22H27ClN6O2