RO 15-4513
- Product Name
- RO 15-4513
- CAS No.
- 91917-65-6
- Chemical Name
- RO 15-4513
- Synonyms
- RO 15-4513;Azidomazenil;Ro15 4513,Ro154513,Ro-15-4513;RO 15-4513 ETHANOL ANTAGONIST;Ethyl-8-azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo-1,4-benzodiazepine-3-carboxylate;ETHYL 8-AZIDO-6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A]-[1,4]BENZODIAZEPINE-3-CARBOXYLATE;8-Azido-5,6-dihydro-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester;4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 8-azido-5,6-dihydro-6-oxo-, ethyl ester;8-AZIDO-5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE-3-CARBOXYLIC ACID ETHYL ESTER;4H-Imidazo(1,5-A)(1,4)benzodiazepine-3-carboxylic acid, 8-azido-5,6-dihydro-5-methyl-6-oxo-, ethyl ester
- CBNumber
- CB2312745
- Molecular Formula
- C15H14N6O3
- Formula Weight
- 326.32
- MOL File
- 91917-65-6.mol
RO 15-4513 Property
- storage temp.
- Desiccate at +4°C
- solubility
- 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.8 mg/mL
- form
- solid
- color
- tan
- CAS DataBase Reference
- 91917-65-6
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- R109
- Product name
- Ro 15-4513
- Purity
- solid
- Packaging
- 25mg
- Price
- $502
- Updated
- 2024/03/01
- Product number
- R109
- Product name
- Ro 15-4513
- Purity
- solid
- Packaging
- 100mg
- Price
- $1700
- Updated
- 2024/03/01
- Product number
- 1997
- Product name
- Ro 15-4513
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $542
- Updated
- 2021/12/16
- Product number
- 1997
- Product name
- Ro 15-4513
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $150
- Updated
- 2021/12/16
- Product number
- R700943
- Product name
- Ro 15-4513
- Packaging
- 1mg
- Price
- $150
- Updated
- 2021/12/16
RO 15-4513 Chemical Properties,Usage,Production
Description
Ro 15-4513 is a partial inverse agonist of benzodiazepine receptors. It acts as a competitive antagonist, and can therefore be an antidote to the acute impairment caused by alcohol. Ro 15-4513's Ki values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Ro 15-4513 displays partial agonism at DI α4- and α6-GABAA receptors.
Chemical Properties
Off-white solid
Uses
Ro 15-4513 has been used as a benzodiazepine (Bz) inverse agonist in rats and to test its binding with diazepam-sensitive (DS) receptors in in vitro radioligand binding studies.
Uses
Ro 15-4513 is an alcohol antagonist.
Definition
ChEBI: 8-azido-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester is an organonitrogen heterocyclic compound and an organic heterotricyclic compound.
Application
Ro 15-4513 is benzodiazepine receptor partial inverse agonist. It elicits anxiogenic property and is an ethanol antagonist. It elicits a high affinity towards diazepam sensitive and insensitive sites in the cerebellar region. Ro 15-4513 possesses an imidazo ring and is an imidazobenzodiazepine.
Biological Activity
High affinity benzodiazepine ligand. K i values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Acts as partial inverse agonist at recombinant DS α 1-, α 2-, α 3- and α 5-GABA A receptors. Displays partial agonism at DI α 4- and α 6-GABA A receptors. Antagonizes several behavioral and neurochemical effects of ethanol. Proconvulsant and anxiogenic.
Biochem/physiol Actions
Ro 15-4513 is benzodiazepine receptor partial inverse agonist. It elicits anxiogenic property and is an ethanol antagonist. It elicits a high affinity towards diazepam sensitive and insensitive sites in the cerebellar region. Ro 15-4513 possesses an imidazo ring and is an imidazobenzodiazepine.
storage
Desiccate at +4°C
RO 15-4513 Preparation Products And Raw materials
Raw materials
Preparation Products
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