RO 15-4513

Product Name: RO 15-4513
CAS No.: 91917-65-6
Chemical Name: RO 15-4513
Synonyms: RO 15-4513;Azidomazenil;Ro15 4513,Ro154513,Ro-15-4513;RO 15-4513 ETHANOL ANTAGONIST;Ethyl-8-azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo-1,4-benzodiazepine-3-carboxylate;ETHYL 8-AZIDO-6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A]-[1,4]BENZODIAZEPINE-3-CARBOXYLATE;8-Azido-5,6-dihydro-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester;4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 8-azido-5,6-dihydro-6-oxo-, ethyl ester;8-AZIDO-5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE-3-CARBOXYLIC ACID ETHYL ESTER;4H-Imidazo(1,5-A)(1,4)benzodiazepine-3-carboxylic acid, 8-azido-5,6-dihydro-5-methyl-6-oxo-, ethyl ester
CBNumber: CB2312745
Molecular Formula: C15H14N6O3
Formula Weight: 326.32
MOL File: 91917-65-6.mol

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RO 15-4513 Property

storage temp.: Desiccate at +4°C
solubility: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.8 mg/mL
form: solid
color: tan
CAS DataBase Reference: 91917-65-6

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: R109
Product name: Ro 15-4513
Purity: solid
Packaging: 25mg
Price: $502
Updated: 2024/03/01

Sigma-Aldrich

Product number: R109
Product name: Ro 15-4513
Purity: solid
Packaging: 100mg
Price: $1700
Updated: 2024/03/01

Tocris

Product number: 1997
Product name: Ro 15-4513
Purity: ≥98%(HPLC)
Packaging: 50
Price: $542
Updated: 2021/12/16

Tocris

Product number: 1997
Product name: Ro 15-4513
Purity: ≥98%(HPLC)
Packaging: 10
Price: $150
Updated: 2021/12/16

TRC

Product number: R700943
Product name: Ro 15-4513
Packaging: 1mg
Price: $150
Updated: 2021/12/16

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RO 15-4513 Chemical Properties,Usage,Production

Description

Ro 15-4513 is a partial inverse agonist of benzodiazepine receptors. It acts as a competitive antagonist, and can therefore be an antidote to the acute impairment caused by alcohol. Ro 15-4513's Ki values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Ro 15-4513 displays partial agonism at DI α4- and α6-GABAA receptors.

Chemical Properties

Off-white solid

Uses

Ro 15-4513 has been used as a benzodiazepine (Bz) inverse agonist in rats and to test its binding with diazepam-sensitive (DS) receptors in in vitro radioligand binding studies.

Uses

Ro 15-4513 is an alcohol antagonist.

Definition

ChEBI: 8-azido-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester is an organonitrogen heterocyclic compound and an organic heterotricyclic compound.

Application

Ro 15-4513 is benzodiazepine receptor partial inverse agonist. It elicits anxiogenic property and is an ethanol antagonist. It elicits a high affinity towards diazepam sensitive and insensitive sites in the cerebellar region. Ro 15-4513 possesses an imidazo ring and is an imidazobenzodiazepine.

Biological Activity

High affinity benzodiazepine ligand. K i values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Acts as partial inverse agonist at recombinant DS α 1-, α 2-, α 3- and α 5-GABA A receptors. Displays partial agonism at DI α 4- and α 6-GABA A receptors. Antagonizes several behavioral and neurochemical effects of ethanol. Proconvulsant and anxiogenic.

Biochem/physiol Actions

Ro 15-4513 is benzodiazepine receptor partial inverse agonist. It elicits anxiogenic property and is an ethanol antagonist. It elicits a high affinity towards diazepam sensitive and insensitive sites in the cerebellar region. Ro 15-4513 possesses an imidazo ring and is an imidazobenzodiazepine.

storage

Desiccate at +4°C

RO 15-4513 Preparation Products And Raw materials

Raw materials

Preparation Products

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RO 15-4513 Suppliers

CHINA 26 Germany 3 Switzerland 1 United Kingdom 2 United States 8 Global 40

3B Pharmachem (Wuhan) International Co.,Ltd.

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91917-65-6, RO 15-4513Related Search:

4-Imidazolemethanol hydrochloride Methyl 4-imidazolecarboxylate Ethyl imidazole-4-carboxylate (1-METHYL-1H-IMIDAZOL-4-YL)METHANOL 5-Methyl-1H-imidazole-4-carbaldehyde 1H-Imidazole-4-carboxylic acid 4-(4-Methyl-1H-imidazol-1-yl)benzenamine 3-AMINO-N,N-DIMETHYLBENZYLAMINE 4-(1H-Imidazol-1-yl)aniline 4,5-DIMETHYL-1H-IMIDAZOLE ETHYL 5-METHYL-1H-IMIDAZOLE-4-CARBOXYLATE 1-METHYL-1H-IMIDAZOLE-4-CARBOXYLIC ACID METHYL ESTER Imidazole-4-methanol 1-Methyl-1H-imidazole-4-carboxylic acid 1-(1H-IMIDAZOL-2-YL)-ETHANOL 1,5-DIMETHYL-1H-IMIDAZOLE-4-CARBALDEHYDE 3-AMINO-N-ETHYLBENZAMIDE 3-AMINO-N,N-DIMETHYLBENZAMIDE

RO 15-4513

8-AZIDO-5,6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A][1,4]BENZODIAZEPINE-3-CARBOXYLIC ACID ETHYL ESTER

ETHYL 8-AZIDO-6-DIHYDRO-5-METHYL-6-OXO-4H-IMIDAZO[1,5-A]-[1,4]BENZODIAZEPINE-3-CARBOXYLATE

4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 8-azido-5,6-dihydro-6-oxo-, ethyl ester

8-Azido-5,6-dihydro-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester

Azidomazenil

Ethyl 8-azido-6-dihyro-5-methyl-6-oxo-4H-imidazo[1,5-A][1,4]benzodiazepine-3-carboxylic acid ethyl ester

4H-Imidazo(1,5-A)(1,4)benzodiazepine-3-carboxylic acid, 8-azido-5,6-dihydro-5-methyl-6-oxo-, ethyl ester

Ethyl-8-azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo-1,4-benzodiazepine-3-carboxylate

RO 15-4513 ETHANOL ANTAGONIST

Ro15 4513,Ro154513,Ro-15-4513

91917-65-6

C15H14N6O3

Click Chemistry

Organic Azides

Specialty Synthesis

Chemical Ligation

GABA/Glycine receptor