(1-METHYL-1H-IMIDAZOL-4-YL)METHANOL

Application

Product Name: (1-METHYL-1H-IMIDAZOL-4-YL)METHANOL
CAS No.: 17289-25-7
Chemical Name: (1-METHYL-1H-IMIDAZOL-4-YL)METHANOL
Synonyms: 1-Methyl-4-imidazolemethanol;(1-methylimidazol-4-yl)methanol;1H-Imidazole-4-methanol, 1-methyl-;(1-METHYL-1H-IMIDAZOL-4-YL)METHANOL;4-(Hydroxymethyl)-1-methylimidazole;(1-Methyl-1H-imidazol-4-yl)methanol97%;(1-Methyl-1H-imidazol-4-yl)methanol 97%
CBNumber: CB2102355
Molecular Formula: C5H8N2O
Formula Weight: 112.13
MOL File: 17289-25-7.mol

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(1-METHYL-1H-IMIDAZOL-4-YL)METHANOL Property

Melting point:: 59.5-63.5
Boiling point:: 324.9±17.0 °C(Predicted)
Density: 1.16±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 13.61±0.10(Predicted)
Appearance: Light yellow to brown Solid
InChI: InChI=1S/C5H8N2O/c1-7-2-5(3-8)6-4-7/h2,4,8H,3H2,1H3
InChIKey: NLEAEGDBKRBJAP-UHFFFAOYSA-N
SMILES: C1N(C)C=C(CO)N=1
CAS DataBase Reference: 17289-25-7

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Safety

Hazard Note: Harmful
HS Code: 2933299090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B497203
Product name: (1-methyl-1H-imidazol-4-yl)methanol
Packaging: 25mg
Price: $45
Updated: 2021/12/16

ChemScene

Product number: CS-W006176
Product name: (1-Methyl-1H-imidazol-4-yl)methanol
Purity: 99.99%
Packaging: 1g
Price: $61
Updated: 2021/12/16

Matrix Scientific

Product number: 119280
Product name: (1-Methyl-1H-imidazol-4-yl)methanol
Purity: 95%
Packaging: 250mg
Price: $144
Updated: 2021/12/16

Apolloscientific

Product number: OR4416
Product name: (1-Methyl-1H-imidazol-4-yl)methanol
Purity: 97%
Packaging: 1g
Price: $148
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-0FJ
Product name: (1-Methyl-1H-imidazol-4-yl)methanol
Purity: 97%
Packaging: 1g
Price: $164
Updated: 2021/12/16

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(1-METHYL-1H-IMIDAZOL-4-YL)METHANOL Chemical Properties,Usage,Production

Application

(1-Methyl-1H-imidazol-4-yl)methanol is an organic intermediate that can be obtained by reducing 1-methyl-imidazol-4-carboxylic acid. It can be further chlorinated to prepare 1-methyl-4-chloromethylimidazolium hydrochloride. As an organic synthesis intermediate and pharmaceutical intermediate, it can be used in laboratory research and development processes and chemical production processes.

Synthesis

41716-18-1

17289-25-7

General procedure for the synthesis of (1-methyl-1H-imidazol-4-yl)methanol from 1-methyl-1H-imidazole-4-carboxylic acid: 1-methyl-1H-imidazole-4-carboxylic acid (25 g, 198 mmol) was dissolved in tetrahydrofuran (THF) (1000 mL) under nitrogen protection. Lithium aluminum hydride (LiAlH4) (15.05 g, 396 mmol) was added slowly at room temperature. The reaction mixture was stirred at 50 °C for 12 hours. Upon completion of the reaction, water (15 mL), 10% sodium hydroxide solution (15 mL), and water (45 mL) were sequentially added to the reaction mixture at 0 °C. The solid was removed by filtration and the filtrate was concentrated to afford the target product (1-methyl-1H-imidazol-4-yl)methanol (13.2 g, 94 mmol, 47.5% yield), which could be used in the next step of the reaction without further purification.LC-MS analysis result: m/z 113.1 ([M + H]+), retention time 0.33 min.

References

[1] Patent: WO2004/13134, 2004, A2. Location in patent: Page 26
[2] Patent: WO2004/13135, 2004, A1. Location in patent: Page 47
[3] Patent: WO2004/16606, 2004, A1. Location in patent: Page 30
[4] Patent: WO2004/13138, 2004, A2. Location in patent: Page 23
[5] Patent: WO2017/60854, 2017, A1. Location in patent: Page/Page column 474; 475

(1-METHYL-1H-IMIDAZOL-4-YL)METHANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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(1-METHYL-1H-IMIDAZOL-4-YL)METHANOL Suppliers

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View Lastest Price from (1-METHYL-1H-IMIDAZOL-4-YL)METHANOL manufacturers

Career Henan Chemical Co

Product: (1-METHYL-1H-IMIDAZOL-4-YL)METHANOL 17289-25-7
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-10

17289-25-7, (1-METHYL-1H-IMIDAZOL-4-YL)METHANOLRelated Search:

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(1-METHYL-1H-IMIDAZOL-4-YL)METHANOL

1-Methyl-4-imidazolemethanol

4-(Hydroxymethyl)-1-methylimidazole

(1-Methyl-1H-imidazol-4-yl)methanol97%

(1-Methyl-1H-imidazol-4-yl)methanol 97%

1H-Imidazole-4-methanol, 1-methyl-

(1-methylimidazol-4-yl)methanol

17289-25-7