ChemicalBook > CAS DataBase List > (R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5- (1H-pyrazol- 5-yl)nicotinamide

(R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5- (1H-pyrazol- 5-yl)nicotinamide

Product Name
(R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5- (1H-pyrazol- 5-yl)nicotinamide
CAS No.
1492952-76-7
Chemical Name
(R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5- (1H-pyrazol- 5-yl)nicotinamide
Synonyms
Asciminib;ABL-001;EOS-61420;L1F3R18W77;ABL001;ABL-001;UNII-L1F3R18W77;asciminib free base;ABL-001 (ASCIMINIB);Asciminib (ABL-001);ABL-001; AB -001; ABL001; ASCIMINIB; ASCIMINIB FREE BASE;
CBNumber
CB23133462
Molecular Formula
C20H18ClF2N5O3
Formula Weight
449.84
MOL File
1492952-76-7.mol
More
Less

(R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5- (1H-pyrazol- 5-yl)nicotinamide Property

Boiling point:
631.7±55.0 °C(Predicted)
Density 
1.518±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:93.0(Max Conc. mg/mL);206.74(Max Conc. mM)
Ethanol:90.0(Max Conc. mg/mL);200.07(Max Conc. mM)
form 
A crystalline solid
pka
10.81±0.70(Predicted)
color 
White to off-white
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
26126
Product name
Asciminib
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
26126
Product name
Asciminib
Packaging
10mg
Price
$477
Updated
2024/03/01
Cayman Chemical
Product number
26126
Product name
Asciminib
Packaging
5mg
Price
$254
Updated
2024/03/01
AK Scientific
Product number
0090DW
Product name
Asciminib
Packaging
5mg
Price
$380
Updated
2021/12/16
ChemScene
Product number
CS-7655
Product name
Asciminib
Purity
99.78%
Packaging
5mg
Price
$155
Updated
2021/12/16
More
Less

(R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5- (1H-pyrazol- 5-yl)nicotinamide Chemical Properties,Usage,Production

Description

Asciminib is the first-in-class Specifically Targeting the ABL1 Myristoyl Pocket (STAMP) inhibitor, which was granted accelerated approval in 2021 for patients with Philadelphia chromosomepositive (Ph+) chronic myeloid leukemia (CML) in chronic phase, previously treated with two or more tyrosine kinase inhibitors (TKIs), and for adult patients with Ph+ CML in chronic phase with the T315I mutation. Asciminib binds to a myristoyl site of the BCR-ABL1 protein and locks the protein into an inactive conformation through a mechanism distinct from those of all other orthosteric TKIs such as imatinib, thus overcoming drug resistance arising from ATPbinding site mutations. Asciminib mimics the function of the myristoylated N-terminus of ABL1 and restores the natural autoinhibition of the ABL1b protein.

Uses

Asciminib comprises ABL kinase inhibitors and/or SLC7A11 inhibitors for the treatment of cancer and central nervous system (CNS) disorders.

General Description

Class: non-receptor tyrosine kinase
Treatment: CML
Elimination half-life = 14.2 h
Protein binding = 97%

target

BCR-ABL1

(R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5- (1H-pyrazol- 5-yl)nicotinamide Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

(R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5- (1H-pyrazol- 5-yl)nicotinamide Suppliers

China 105 India 1 United States 7 USA 1 Global 114
Changzhou Borl Biotechnology Co.,LTD
Tel
13606124132;13656121842
Email
luyan0021@163.com
Country
China
ProdList
219
Advantage
58
Shanghai Changyu Medical Technology Co. Ltd.
Tel
+86-13301875428
Email
sales@changyuhe.com
Country
China
ProdList
305
Advantage
58
Shanghai Luofa Biochemical Technology Co., Ltd.
Tel
021-51111890 15317326293
Email
sales@molnova.com
Country
China
ProdList
4195
Advantage
58
ChengDu TongChuangYuan Pharmaceutical Co.Ltd
Tel
028-83379370 13880556291
Fax
028-87747383
Email
tcy@tcypharm.com
Country
China
ProdList
6268
Advantage
58
Olix (Shanghai) Pharmaceutical Technology Co., Ltd
Tel
17316404525
Email
209533805@qq.com
Country
China
ProdList
9762
Advantage
58
Anhui Lianchuang Biological Medicine Co.,Ltd
Tel
0551-68779238 18056025720
Email
sales3@lcywhx.com
Country
China
ProdList
159
Advantage
57
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 17702719238
Email
sales@sun-shinechem.com
Country
China
ProdList
976
Advantage
64
Wuhan ariel chemical Co., LTD.
Tel
18986259541 18986259541
Fax
027-87840182
Email
sales@3stc.com
Country
China
ProdList
4004
Advantage
58
Shanghai Topbiochem Technology Co., Ltd
Tel
021-58170097
Email
info@topbiochem.com
Country
China
ProdList
9459
Advantage
58
Shanghai Famo Bio-chemical Technology Company Ltd.
Tel
021-021-36680027 15800370750
Email
1706640024@qq.com
Country
China
ProdList
540
Advantage
56
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3466
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
18042
Advantage
56
ShangHai KenEn Chemical Technology Co., Ltd.
Tel
13120367189
Fax
021-50315529
Email
mychess007@163.com
Country
China
ProdList
1994
Advantage
55
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4512
Advantage
55
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
Advantage
62
Jinan elephant international trading co., LTD
Tel
Fax
-
Email
13006575422@163.com
Country
China
ProdList
6355
Advantage
58
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
7267
Advantage
58
Shanghai SuperLan Chemcial Technique Centre
Tel
021-2022843681 15618226720
Fax
+86-21-51601218
Email
lucy@atkchemical.com
Country
China
ProdList
9204
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 4009686088
Email
3193328036@qq.com
Country
China
ProdList
29785
Advantage
68
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Zhongshan Geometric Biological Technology Co., Ltd.
Tel
+86-13168912896
Country
China
ProdList
253
Advantage
58
Chuzhou KeMail Chemical Technology Co., Ltd
Tel
0550-5196001 15000891977
Fax
0550-5196001
Email
wj520wjxby@126.com
Country
China
ProdList
1847
Advantage
55
Kaixin Chemical (Hong Kong) Limited
Tel
010-88886666-01 13112345678
Fax
CDXH21@126.com
Email
loyson@tcypharm.com
Country
China
ProdList
595
Advantage
55
Wellman Pharmaceutical Group Limited
Tel
027-027-83778875 15807197853
Fax
027-83991220
Email
15807197853@163.com
Country
China
ProdList
4014
Advantage
58
AnHui HaiKang Pharmaceutical Co., Ltd.
Tel
0556-5800026 17709662922
Email
melrose@worldpharma.cn
Country
China
ProdList
247
Advantage
55
Shanghai Biopharmaleader Co., Ltd.
Tel
+86 18721201413
Fax
+86 (21) 5775-8967
Email
sales@biopharmaleader.com
Country
China
ProdList
1720
Advantage
58
Wuhan Sun-shine Bio-technology Corporation Limited
Tel
+86-027-6552-2453
Email
sales@sun-shinechem.com
Country
China
ProdList
727
Advantage
58
Rhawn Reagent
Tel
400-400-1332688 18019345275
Fax
400-133-2688
Email
amy@rhawn.cn
Country
China
ProdList
15497
Advantage
58
Twochem Co.Ltd.
Tel
021-58111628 15800915896
Fax
QQ 3285589261
Email
sales@twochem.com
Country
China
ProdList
1788
Advantage
58
Shanghai ring qi biological technology co., LTD
Tel
13524106587
Email
sales@hq-chem.com
Country
China
ProdList
225
Advantage
58
ROSEWA HOLDING GROUP CO.,LIMITED
Tel
+86-023-62871537
Email
sales@rosewachem.com
Country
China
ProdList
2828
Advantage
58
Guangzhou Tomums Life Science Co., Ltd.
Tel
020-31155029 18902330969
Fax
020-31155029
Email
sales@tomums.cn
Country
China
ProdList
4696
Advantage
58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd
Tel
0571-85361029
Fax
0571-85361029
Email
synstar518@163.com
Country
China
ProdList
1990
Advantage
58
Shanghai zhigan biotechnology co., LTD
Tel
Email
zhiqianbio@126.com
Country
China
ProdList
19778
Advantage
58
Tianjin Kaifu Pharmaceutical Technology Co., Ltd.
Tel
18081075745
Email
chemflowtech@sina.com
Country
China
ProdList
1886
Advantage
58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
Tel
meitaochem@126.com
Email
meitaochem@126.com
Country
China
ProdList
19103
Advantage
58
Zhejiang J&C Biological Technology Co.,Limited
Tel
+1-2135480471 +1-2135480471
Email
sales@sarms4muscle.com
Country
China
ProdList
10473
Advantage
58
Wuhan Demeikai Biotechnology Co., Ltd
Tel
+8618942921723
Email
info@dmksw.xin
Country
China
ProdList
717
Advantage
58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
ProdList
6312
Advantage
58
Anqing Chemical (Luoyang) Co., Ltd.
Tel
13592012365
Email
171008495@qq.com
Country
China
ProdList
26
Advantage
58
Wuhan Weiyuan Biotechnology Co., Ltd.
Tel
15608644787
Email
13872128609@163.com
Country
CHINA
ProdList
96
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9409
Advantage
58
Shanghai Yanze Chemical Co., Ltd.
Tel
021-13773155751 19975051755
Email
260924549@qq.com
Country
China
ProdList
8904
Advantage
58
Hefei fuya biotechnology co. LTD
Tel
18096409024
Email
sales02@foreversyn.com
Country
China
ProdList
1918
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11217
Advantage
58
Shanghai Zeye Biotechnology Co., Ltd.
Tel
021-61998551 13122364865
Email
sale1@shzysw.net
Country
China
ProdList
9772
Advantage
58
Guangzhou Younan Technology Co., Ltd
Tel
020-82000279 18988968278
Fax
QQ：3283937693
Email
sales@ubiochem.com
Country
China
ProdList
4297
Advantage
58
Absin Bioscience Inc.
Tel
021-38015121 15000105423
Email
wulan@absin.cn
Country
China
ProdList
24731
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58

1492952-76-7, (R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5- (1H-pyrazol- 5-yl)nicotinamideRelated Search:

CCT 244747 6-amino-1,3-dimethyl-4-(4-(trifluoromethyl)phenyl)-1,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile 1-[2-CHLORO-6-[[(3-IODOPHENYL)METHYL]AMINO]-9H-PURIN-9-YL]-1-DEOXY-N-METHYL-BETA-D-RIBOFURANURONAMIDE Naquotinib (mesylate) HS-173 BI-9564 BenzaMide, 4-[[2-[3,5-bis(trifluoroMethyl)phenyl]-4,5-bis(4-Methoxyphenyl)-1H-iMidazol-1-yl]Methyl]- 4-Propylphenol

  • ABL001;ABL-001
  • ABL-001; AB -001; ABL001; ASCIMINIB; ASCIMINIB FREE BASE;
  • asciminib free base
  • (R)-N- (4-(CHLORODIFLUOROMETHOXY)PHENYL)- 6-(3- HYDROXYPYRROLIDIN-1- YL)-5- (1H-PYRAZOL- 5-YL)NICOTI
  • (R)-N- (4-(chlorodifluoromethoxy)phenyl)- 6-(3- hydroxypyrrolidin-1- yl)-5- (1H-pyrazol- 5-yl)nicotinamide
  • ABL-001
  • Asciminib
  • EOS-61420
  • L1F3R18W77
  • UNII-L1F3R18W77
  • 3-Pyridinecarboxamide, N-[4-(chlorodifluoromethoxy)phenyl]-6-[(3R)-3-hydroxy-1-pyrrolidinyl]-5-(1H-pyrazol-3-yl)-
  • Asciminib (ABL-001)
  • ABL-001 (ASCIMINIB)
  • (R)-N-(4-(Chlorodifluoromethoxy)phenyl)-6-(3-hydroxypyrrolidin-1-yl)-5-(1H-pyrazol-3-yl)nicotinamide
  • 1492952-76-7
  • C20H18ClF2N5O3