[4-(4-METHYLPIPERAZINO)PHENYL]METHANOL
- Product Name
- [4-(4-METHYLPIPERAZINO)PHENYL]METHANOL
- CAS No.
- 342405-34-9
- Chemical Name
- [4-(4-METHYLPIPERAZINO)PHENYL]METHANOL
- Synonyms
- BUTTPARK 98\50-53;RARECHEM AL BD 1090;4-(4-METHYLPIPERAZINO)BENZYL ALCOHOL;[4-(4-METHYLPIPERAZINO)PHENYL]METHANOL;4-(4-N-Methylpiperazinyl)benzyl alcohol;4-(4-Methylpiperazin-1-yl)benzyl alcohol;4-(4-Methyl-1-piperazinyl)benzenemethanol;[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]METHANOL;Benzenemethanol, 4-(4-methyl-1-piperazinyl)-;(4-(4-Methylpiperazin-1-yl)phenyl)methanol - [M89622]
- CBNumber
- CB2313742
- Molecular Formula
- C12H18N2O
- Formula Weight
- 206.28
- MOL File
- 342405-34-9.mol
[4-(4-METHYLPIPERAZINO)PHENYL]METHANOL Property
- Melting point:
- 118-120°C
- Boiling point:
- 363.7±42.0 °C(Predicted)
- Density
- 1.105±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 15.05±0.10(Predicted)
- Appearance
- White to light yellow Solid
- Odor
- almond nutty
- LogP
- 0.135 (est)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 34-36/37/38
- Safety Statements
- 26-36/37/39
- RIDADR
- 1759
- HazardClass
- IRRITANT
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P310Immediately call a POISON CENTER or doctor/physician.
N-Bromosuccinimide Price
- Product number
- M219220
- Product name
- 4-(4-Methylpiperazino)benzylAlcohol
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR23310
- Product name
- 4-(4-Methylpiperazin-1-yl)benzylalcohol
- Packaging
- 250mg
- Price
- $15
- Updated
- 2021/12/16
- Product number
- 4H56-1-XR
- Product name
- 4-(4-Methylpiperazin-1-yl)benzyl alcohol
- Packaging
- 250mg
- Price
- $16
- Updated
- 2021/12/16
- Product number
- OR23310
- Product name
- 4-(4-Methylpiperazin-1-yl)benzylalcohol
- Packaging
- 1g
- Price
- $18
- Updated
- 2021/12/16
- Product number
- 4H56-1-XR
- Product name
- 4-(4-Methylpiperazin-1-yl)benzyl alcohol
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
[4-(4-METHYLPIPERAZINO)PHENYL]METHANOL Chemical Properties,Usage,Production
Synthesis
197638-83-8
342405-34-9
General procedure for the synthesis of 4-(4-methylpiperazine)benzyl alcohol from 1-BOC-4-(4-formylphenyl)piperazine: tert-butyl 4-(4-formylphenyl)-piperazine-1-carboxylate (1.3 g, 4.47 mmol) was dissolved in THF (50 mL), lithium aluminium hydroxide (LAH, 0.7 g, 17.87 mmol) was added with stirring and refluxing at 37 °C for for 14 hours. After completion of the reaction, the reaction was quenched with 14 N aqueous KOH (20 mL) at room temperature. The supernatant was separated, combined with the DCM wash solution and diluted with water (50 mL). The mixture was extracted with DCM (3 x 50 mL), the organic phases were combined and concentrated by rotary evaporator to give [4-(4-methylpiperazin-1-yl)phenyl]methanol (0.82 g, 89% yield). DMSO (0.56 mL, 7.96 mmol) was dissolved in DCM (50 mL), oxalyl chloride (0.7 mL, 7.96 mmol) was added and stirred at -78 °C for 0.5 h. The mixture was then dissolved in DCM (50 mL). A solution of [4-(4-methylpiperazin-1-yl)phenyl]methanol (0.82 g, 3.98 mmol) in DCM (20 mL) was added slowly and stirring was continued for 1.5 hours at -78 °C. Triethylamine (1.7 mL, 11.94 mmol) was added to gradually warm the reaction mixture to room temperature. After stirring for 4 h, the reaction was quenched with 1 N aqueous sodium bicarbonate (50 mL). The mixture was extracted with DCM (3 x 50 mL), the organic phases were combined and concentrated to give a residue, which was purified by column chromatography to give 4-(4-methylpiperazin-1-yl)benzaldehyde (0.5 g). Further, 5,7-dimethoxy-2-(4-(4-methylpiperazin-1-yl)phenyl)quinazolin-4(3H)-one (120 mg, 41% yield) was converted to its hydrochloride salt (yellow solid). Characterization data: MS (m/z): 381.11; melting point 252.4-254.2 °C (dihydrochloride).
References
[1] Patent: US2008/188467, 2008, A1. Location in patent: Page/Page column 38-39
[2] Patent: US2013/281397, 2013, A1. Location in patent: Paragraph 0522; 0523
[4-(4-METHYLPIPERAZINO)PHENYL]METHANOL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from [4-(4-METHYLPIPERAZINO)PHENYL]METHANOL manufacturers
- Product
- [4-(4-METHYLPIPERAZINO)PHENYL]METHANOL 342405-34-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09