NSC-12 Property

Boiling point:

521.8±45.0 °C(Predicted)

Density 

1.31±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 2 mg/ml; DMSO: 0.1 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2)(1:2): 0.33 mg/ml

form 

A crystalline solid

pka

9.50±0.29(Predicted)

color 

White to light yellow

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H400Very toxic to aquatic life

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P273Avoid release to the environment.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P391Collect spillage. Hazardous to the aquatic environment

P501Dispose of contents/container to..…

NSC-12 Chemical Properties,Usage,Production

Biological Activity

NSC12 (NSC 172285) is an orally available inhibitor of FGF2/FGFR interaction with potential antitumor activity.

in vitro

NSC-12 can inhibit FGF-dependent tumor growth, angiogenesis and metastasis. It did not affect FGF2/heparin interaction, but inhibited FGF2 binding to immobilized receptors (IC50 ~30 μM), it disrupted FGF2 interaction with FGFR1, and had no effect on the interaction activity of growth factors with heparin or HSPGs .

in vivo

Administered by injection and oral route, NSC-12 inhibits FGFR activation, tumor growth, angiogenesis and metastasis in FGF-dependent mouse and human tumor models. In animal models, it significantly reduced tumor weight, tumor cell FGFR1 phosphorylation levels and proliferation, and tumor CD31+ cardiovascular formation.

target

Target	Value
FGF3 (Cell-free assay)	15.9 μM(Kd)
FGF8b (Cell-free assay)	18.9 μM(Kd)
FGF22 (Cell-free assay)	26.8 μM(Kd)
FGF20 (Cell-free assay)	29.4 μM(Kd)
FGF2/FGFR (Cell-free assay)	30 μM