WNK463

ChemicalBook > CAS DataBase List > WNK463

Product Name: WNK463
CAS No.: 2012607-27-9
Chemical Name: WNK463
Synonyms: WNK463;CS-2515;WNK 463;WNK-463;Ser/Thr Protease,WNK 463,inhibit,WNK463,Serine proteases,Inhibitor,Serine endopeptidases,Threonine proteases,WNK-463;1H-Imidazole-5-carboxamide, N-(1,1-dimethylethyl)-1-[1-[5-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]-2-pyridinyl]-4-piperidinyl]-
CBNumber: CB23145823
Molecular Formula: C21H24F3N7O2
Formula Weight: 463.46
MOL File: 2012607-27-9.mol

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WNK463 Property

Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
solubility: DMSO : ≥ 30 mg/mL (64.73 mM)
pka: 15.18±0.46(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2809
Product name: WNK463
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $118
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2809
Product name: WNK463
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $453
Updated: 2024/03/01

TRC

Product number: W499305
Product name: WNK463
Packaging: 5mg
Price: $360
Updated: 2021/12/16

AK Scientific

Product number: 6099EG
Product name: N-Tert-butyl-3-[1-[5-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]pyridin-2-yl]piperidin-4-yl]imidazole-4-carboxamide
Packaging: 10mg
Price: $378
Updated: 2021/12/16

ChemScene

Product number: CS-5921
Product name: WNK463
Purity: 99.55%
Packaging: 25mg
Price: $480
Updated: 2021/12/16

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WNK463 Chemical Properties,Usage,Production

Uses

WNK 463, is a pan-WNK kinase inhibitor, acting on WNK1, WNK2, WNK3, and WNK4 kinases. It has shown to affect blood pressure, heart rate, body fluid and electrolyte homeostasis in rodent models of hypertension.

Biochem/physiol Actions

WNK463 is a high-affinity, ATP-competitive inhibitor against with-No-Lysine (K) kinases (hWNK1/3/4 IC50 = 5/6/9 nM with MBP & 1 μM ATP, hWNK2 IC50 = 1 nM with MBP & 2 μM ATP, hWNK1 IC50 = 41 nM with OSR1 & 0.5 μM ATP; hWNK1/4 KD = 3.71/3.84 by SPR), exhibiting weak affinity against only two other human kinases among a panel of 442. WNK463 downregulates the overexpressed OSR1 phosphorylation level in HEK293 cells (IC50 = 106 nM; 1 hr) and displays in vivo efficacy in rodent hypertension models (1-10 mg/kg in rats p.o., 10 mg/kg in hWNK1 transgenic mice p.o.) with good orally availability (F = 100%/mice & 74%/rats post 1.5 mg/kg p.o.).

WNK463 Preparation Products And Raw materials

Raw materials

Preparation Products

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2012607-27-9, WNK463Related Search:

Allosteric WNK Kinase Inhibitor ,

WNK463

WNK 463;WNK-463

CS-2515

1H-Imidazole-5-carboxamide, N-(1,1-dimethylethyl)-1-[1-[5-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]-2-pyridinyl]-4-piperidinyl]-

Ser/Thr Protease,WNK 463,inhibit,WNK463,Serine proteases,Inhibitor,Serine endopeptidases,Threonine proteases,WNK-463

2012607-27-9

C21H24F3N7O2