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HSF1A

Product Name
HSF1A
CAS No.
1196723-93-9
Chemical Name
HSF1A
Synonyms
HSF1A;HSF1A ，S0294;HSF1 Activator;CAS 1196723-93-9;HSF1 Activator HSF1A;HSF1A, 10 mM in DMSO;HSF1 ACTIVATOR;HSF1A;CAS 1196723-93-9;Inhibitor,HSP,inhibit,Heat shock proteins,HSF1A,HSF-1A;4-Ethyl-N-[1-phenyl-3-(2-thienyl)-5-pyrazolyl]benzenesulfonamide;Benzenesulfonamide, 4-ethyl-N-[1-phenyl-3-(2-thienyl)-1H-pyrazol-5-yl]-
CBNumber
CB23146305
Molecular Formula
C21H19N3O2S2
Formula Weight
409.52
MOL File
1196723-93-9.mol
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HSF1A Property

Boiling point:
592.6±60.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:116.0(Max Conc. mg/mL);283.26(Max Conc. mM)
form 
Solid
pka
6.53±0.10(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-7837
Product name
HSF1A
Purity
99.43%
Packaging
2mg
Price
$120
Updated
2021/12/16
ChemScene
Product number
CS-7837
Product name
HSF1A
Purity
99.43%
Packaging
5mg
Price
$180
Updated
2021/12/16
ChemScene
Product number
CS-7837
Product name
HSF1A
Purity
99.43%
Packaging
10mg
Price
$264
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0017260
Product name
HSF-1A
Purity
95.00%
Packaging
5MG
Price
$504.17
Updated
2021/12/16
ChemScene
Product number
CS-7837
Product name
HSF1A
Purity
99.43%
Packaging
25mg
Price
$588
Updated
2021/12/16
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HSF1A Chemical Properties,Usage,Production

Uses

HSF1A is a cell-permeable activator of heat shock transcription factor 1 (HSF1)[1]. HSF1A also acts as a specific inhibitor of TRiC/CCT. Chaperonin TCP-1 ring complex (TRiC)/chaperonin containing TCP-1 (CCT) plays a pivotal role in toxin translocation and/or refolding[4].

Biological Activity

Cell permeable: yes', 'Primary Target
HSF1

in vivo

HSF1A enhances HSF1 activity, stabilizes HSF1 expression and minimizes Doxorubicin (DOX)-induced cardiac damage. WKY rats are challenged with DOX (accumulated dose: 30 mg/kgw), and DOX combined with HSF1A (100 mg/kgw/day). Supplementation with HSF1A significantly elevates cardiac functions back to the levels of the control group. HSF1A has been shown to stimulate human HSF1 nuclear translocation, elevate protein chaperone expression and ameliorate protein misfolding and cell death in a neurodegenerative disease model. The echocardiographic results show that HSF1A also alleviates DOX-induced failures in cardiac function[3].

IC 50

HSF1

References

[1] Neef DW, et al. A direct regulatory interaction between chaperonin TRiC and stress-responsive transcription factor HSF1. Cell Rep. 2014 Nov 6;9(3):955-66. DOI:10.1016/j.celrep.2014.09.056
[2] Neef DW, et al. Modulation of heat shock transcription factor 1 as a therapeutic target for small molecule intervention in neurodegenerative disease. PLoS Biol. 2010 Jan 19;8(1):e1000291. DOI:10.1371/journal.pbio.1000291
[3] Huang CY, et al. Doxorubicin attenuates CHIP-guarded HSF1 nuclear translocation and protein stability to trigger IGF-IIR-dependent cardiomyocyte death. Cell Death Dis. 2016 Nov 3;7(11):e2455. DOI:10.1038/cddis.2016.356
[4] Marcus Steinemann, et al. The chaperonin TRiC/CCT is essential for the action of bacterial glycosylating protein toxins like Clostridium difficile toxins A and B. Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9580-9585. DOI:10.1073/pnas.1807658115

HSF1A Preparation Products And Raw materials

Raw materials

Preparation Products

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HSF1A Suppliers

China 63 United States 6 USA 1 Global 70
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Abcam Limited
Tel
--
Fax
--
Email
us.orders@abcam.com
Country
United States
ProdList
6001
Advantage
50
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View Lastest Price from HSF1A manufacturers

Career Henan Chemical Co
Product
HSF1A 1196723-93-9
Price
US $1.00/g
Min. Order
1g
Purity
99.99%
Supply Ability
200kg
Release date
2019-12-24

1196723-93-9, HSF1ARelated Search:

CALCISEPTINE

  • HSF1A
  • HSF1 ACTIVATOR;HSF1A;CAS 1196723-93-9
  • CAS 1196723-93-9
  • HSF1 Activator
  • Benzenesulfonamide, 4-ethyl-N-[1-phenyl-3-(2-thienyl)-1H-pyrazol-5-yl]-
  • 4-Ethyl-N-(1-phenyl-3-(thiophen-2-yl)-1H-pyrazol-5-yl)benzenesulfonamide
  • Inhibitor,HSP,inhibit,Heat shock proteins,HSF1A,HSF-1A
  • HSF1A, 10 mM in DMSO
  • HSF1 Activator HSF1A
  • 4-Ethyl-N-[1-phenyl-3-(2-thienyl)-5-pyrazolyl]benzenesulfonamide
  • HSF1A ，S0294
  • 1196723-93-9
  • API