ChemicalBook > CAS DataBase List > SP 141

SP 141

Product Name
SP 141
CAS No.
1253491-42-7
Chemical Name
SP 141
Synonyms
SP 141;SP 141;SP141;;6-Methoxy-1-(1-naphthyl)-9H-β-carboline;6-Methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole;6-methoxy-1-(naphthalen-1-yl)-9H-pyrido[3,4-b]indole;9H-Pyrido[3,4-b]indole, 6-methoxy-1-(1-naphthalenyl)-;pancreatic,SP-141,inhibit,Inhibitor,cancer,MDM-2/p53,breast,degradation,auto-ubiquitination,SP141
CBNumber
CB23146385
Molecular Formula
C22H16N2O
Formula Weight
324.38
MOL File
1253491-42-7.mol
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SP 141 Property

Boiling point:
571.2±45.0 °C(Predicted)
Density 
1.284±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≤100mg/ml in ethanol;30mg/ml in DMSO;50mg/ml in dimethyl formamide
form 
crystalline solid
pka
15.04±0.40(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
17003
Product name
SP 141
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
17003
Product name
SP 141
Purity
≥98%
Packaging
5mg
Price
$118
Updated
2024/03/01
Cayman Chemical
Product number
17003
Product name
SP 141
Purity
≥98%
Packaging
10mg
Price
$193
Updated
2024/03/01
Cayman Chemical
Product number
17003
Product name
SP 141
Purity
≥98%
Packaging
50mg
Price
$849
Updated
2024/03/01
Tocris
Product number
5332
Product name
SP141
Purity
≥98%(HPLC)
Packaging
50
Price
$870
Updated
2021/12/16
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SP 141 Chemical Properties,Usage,Production

Description

Mouse double minute 2 protein (MDM2) is an E3 ubiquitin-protein ligase that binds and ubiquitinates the tumor suppressor p53, leading to its degradation by the proteasome. SP 141 is a cell-permeable inhibitor of MDM2 (Ki = 28 nM). Binding of MDM2 by SP 141 promotes its auto-ubiquitination and proteasomal degradation. SP 141 induces cell cycle arrest and apoptosis in breast and pancreatic cancer cell lines and inhibits xenograft tumor growth in vivo. This compound has a short half-life in plasma and wide tissue distribution in tumor-bearing nude mice.

Uses

SP 141 induces cell cycle arrest and apoptosis in breast and pancreatic cancer cell lines, inhibiting xenograft tumor growth in vivo.

storage

Store at +4°C

References

[1]. vassilev lt, vu bt, graves b, et al. in vivo activation of the p53 pathway by small-molecule antagonists of mdm2. science. 2004 feb 6;303(5659):844-8.
[2]. wang w, qin jj, voruganti s, et al. the pyrido[b]indole mdm2 inhibitor sp-141 exerts potent therapeutic effects in breast cancer models. nat commun. 2014 oct 1;5:5086.
[3]. wang w, qin jj, voruganti s, et al. identification of a new class of mdm2 inhibitor that inhibits growth of orthotopic pancreatic tumors in mice. gastroenterology. 2014 oct;147(4):893-902.e2.
[4]. nag s, qin jj, voruganti s, et al. development and validation of a rapid hplc method for quantitation of sp-141, a novel pyrido[b]indole anticancer agent, and an initial pharmacokinetic study in mice. biomed chromatogr. 2015 may;29(5):654-63.

SP 141 Preparation Products And Raw materials

Raw materials

Preparation Products

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SP 141 Suppliers

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1253491-42-7, SP 141Related Search:


  • SP 141
  • 6-Methoxy-1-(1-naphthyl)-9H-β-carboline
  • 6-Methoxy-1-(1-naphthalenyl)-9H-pyrido[3,4-b]indole
  • SP 141;SP141;
  • 9H-Pyrido[3,4-b]indole, 6-methoxy-1-(1-naphthalenyl)-
  • 6-methoxy-1-(naphthalen-1-yl)-9H-pyrido[3,4-b]indole
  • pancreatic,SP-141,inhibit,Inhibitor,cancer,MDM-2/p53,breast,degradation,auto-ubiquitination,SP141
  • 1253491-42-7
  • API